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| 1 | BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy显示文摘Dysregulation of circadian rhythms associates with cardiovascular disorders.It is known that deletion of the core circadian gene Bma/1 in mice causes dilated car-diomyopathy.However,the biological rhythm regulation system in mouse is very different from that of humans.Whether BMAL1 plays a role in regulating human heart function remains unclear.Here we generated a BMAL1 knockout human embryonic stem cell(hESC)model and further derived human BMAL1 deficient cardiomy-ocytes.We show that BMAL1 deficient hESC-derived cardiomyocytes exhibited typical phenotypes of dilated cardiomyopathy including attenuated contractility,cal-cium dysregulation,and disorganized myofilaments.In addition,mitochondrial fission and mitophagy were suppressed in BMAL1 deficient hESC-cardiomyocytes,which resulted in significantly attenuated mitochondrial oxidative phosphorylation and compromised cardiomy-ocyte function.We also found that BMAL1 binds to the E-box element in the promoter region of BNIP3 gene and specifically controls BNIP3 protein expression.BMAL1 knockout directly reduced BNIP3 protein level,causing compromised mitophagy and mitochondria dysfunction and thereby leading to compromised cardiomyocyte function.Our data indicated that the core circadian gene S/VMLf is critical for normal mitochondria activities and cardiac function.Circadian rhythm disruption may directly link to compromised heart function and dilated cardiomyopathy in humans. | Ermin Li Xiuya Li Jie Huang Chen Xu Qianqian Liang Kehan Ren Aobing Bai Chao Lu Ruizhe Qian Ning Sun | 2020 | Protein & Cell2020，11，9： | 17 |
| 2 | Multichannel vectorial holographic display and encryption显示文摘Since its invention,holography has emerged as a powerful tool to fully reconstruct the wavefronts of light including all the fundamental properties(amplitude,phase,polarization,wave vector,and frequency).For exploring the full capability for information storage/display and enhancing the encryption security of metasurface holograms,smart multiplexing techniques together with suitable metasurface designs are highly demanded.Here,we integrate multiple polarization manipulation channels for various spatial phase profiles into a single birefringent vectorial hologram by completely avoiding unwanted cross-talk.Multiple independent target phase profiles with quantified phase relations that can process significantly different information in different polarization states are realized within a single metasurface.For our metasurface holograms,we demonstrate high fidelity,large efficiency,broadband operation,and a total of twelve polarization channels.Such multichannel polarization multiplexing can be used for dynamic vectorial holographic display and can provide triple protection for optical security.The concept is appealing for applications of arbitrary spin to angular momentum conversion and various phase modulation/beam shaping elements. | Ruizhe Zhao Basudeb Sain Qunshuo Wei Chengchun Tang Xiaowei Li Thomas Weiss Lingling Huang Yongtian Wang Thomas Zentgraf | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 3 | Reconfigurable intelligent surfaces for smart wireless environments:channel estimation,system design and applications in 6G networks显示文摘Reconfigurable intelligent surface(RIS),one of the key enablers for the sixth-generation(6G)mobile communication networks,is considered by designers to smartly reconfigure the wireless propagation environment in a controllable and programmable manner.Specifically,an RIS consists of a large number of low-cost and passive reflective elements(REs)without radio frequency chains.The system gain of RIS wireless systems can be achieved by adjusting the phase shifts and amplitudes of the REs so that the desired signals can be added constructively at the receiver.However,an RIS typically has limited signal processing capability and cannot perform active transmitting/receiving in general,which leads to new challenges in the physical layer design of RIS wireless systems.In this paper,we provide an overview of the RIS-aided wireless systems,including the reflection principle,channel estimation,and system design.In particular,two types of emerging RIS systems are considered:RIS-aided wireless communications(RAWC)and RISbased information transmission(RBIT),where the RIS plays the role of the reflector and the transmitter,respectively.We also envision the potential applications of RIS in 6G networks. | Ying-Chang LIANG Jie CHEN Ruizhe LONG Zhen-Qing HE Xianqi LIN Chenlu HUANG Shilin LIU Xuemin(Sherman)SHEN Marco DI RENZO | 2021 | Science China(Information Sciences)2021，64，10： | 12 |
| 4 | Large Intelligent Surface/Antennas (LISA): Making Reflective Radios Smart显示文摘Large intelligent surface/antennas(LISA),a two-dimensional artificial structure with a large number of reflective-surface/antenna elements,is a promising reflective radio technology to construct programmable wireless environments in a smart way.Specifically,each element of the LISA adjusts the reflection of the incident electromagnetic waves with unnatural properties,such as negative refraction,perfect absorption,and anomalous reflection,thus the wireless environments can be software-defined according to various design objectives.In this paper,we introduce the reflective radio basics,including backscattering principles,backscatter communication,reflective relay,the fundamentals and implementations of LISA technology.Then,we present an overview of the state-of-the-art research on emerging applications of LISA-aided wireless networks.Finally,the limitations,challenges,and open issues associated with LISA for future wireless applications are discussed. | Ying-Chang Liang Ruizhe Long Qianqian Zhang Jie Chen Hei Victor Cheng Huayan Guo | 2019 | Journal of Communications and Information Networks2019，4，2： | 5 |
| 5 | Blockchain and MEC-Assisted Reliable Billing Data Transmission over Electric Vehicular Network:An Actor–Critic RL Approach显示文摘Recently,electric vehicles(EVs)have been widely used under the call of green travel and environmental protection,and diverse requirements for charging are also increasing gradually.In order to ensure the authenticity and privacy of charging information interaction,blockchain technology is proposed and applied in charging station billing systems.However,there are some issues in blockchain itself,including lower computing efficiency of the nodes and higher energy consumption in the consensus process.To handle the above issues,in this paper,combining blockchain and mobile edge computing(MEC),we develop a reliable billing data transmission scheme to improve the computing capacity of nodes and reduce the energy consumption of the consensus process.By jointly optimizing the primary and replica nodes offloading decisions,block size and block interval,the transaction throughput of the blockchain system is maximized,as well as the latency and energy consumption of the system are minimized.Moreover,we formulate the joint optimization problem as a Markov decision process(MDP).To tackle the dynamic and continuity of the system state,the reinforcement learning(RL)is introduced to solve the MDP problem.Finally,simulation results demonstrate that the performance improvement of the proposed scheme through comparison with other existing schemes. | Xinyu Ye Meng Li Pengbo Si Ruizhe Yang Enchang Sun Yanhua Zhang | 2021 | China Communications2021，18，8： | 3 |
| 6 | Time-sequential color code division multiplexing holographic display with metasurface显示文摘Color metasurface holograms are powerful and versatile platforms for modulating the amplitude,phase,polarization,and other properties of light at multiple operating wavelengths.However,the current color metasurface holography can only realize static manipulation.In this study,we propose and demonstrate a multiplexing metasurface technique combined with multiwavelength code-division multiplexing(CDM)to realize dynamic manipulation.Multicolor code references are utilized to record information within a single metasurface and increase the information capacity and security for anticracks.A total of 48 monochrome images consisting of pure color characters and multilevel color video frames were reconstructed in dual polarization channels of the birefringent metasurface to exhibit high information density,and a video was displayed via sequential illumination of the corresponding code patterns to verify the ability of dynamic manipulation.Our approach demonstrates significant application potential in optical data storage,optical encryption,multiwavelengthversatile diffractive optical elements,and stimulated emission depletion microscopy. | Xin Li Qinmiao Chen Xue Zhang Ruizhe Zhao Shumin Xiao Yongtian Wang Lingling Huang | 2023 | Opto-Electronic Advances2023，6，8： | 3 |
| 7 | Effect of Support on Catalytic Performance of Photothermal Fischer-Tropsch Synthesis to Produce Lower Olefins over FesC2-based Catalysts显示文摘Photothermal Fischer-Tropsch synthesis(FTS)has been extensively studied,but few reports were focused on systematically exploring the influence of support on catalytic performance.Herein,a series of Fe5C2-based catalysts with different supports was fabricated via a one-step wet-chemical method for photothermal conversion of syngas to lower olefins.Under light irradiation,the optimized FesC2/a-Al2O3 catalyst demonstrated remarkable photothermal FTS activity,delivering selectivity to lower olefins of 50.3%with a CO conversion rate of 52.5%.Characterization studies using X-ray diffraction and Mossbauer spectroscopy analysis revealed that the active catalyst mainly contained FesC2 nanoparticles on a-AbO3 support.It was found that the weak interaction between active phase and a-AhO3 could promote the formation of FesC2,which contributed to the high selectivity to lower olefins. | LI Yuan LI Ruizhe LI Zhenhua WEI Weiqin OUYANG Shuxin YUAN Hong ZHANG Tierui | 2020 | Chemical Research in Chinese Universities2020，36，6： | 3 |
| 8 | Fluorine in drinking water and urine in the urban and rural areas of northwestern China——Its determination by a fluoride ion selective electrode显示文摘In this study, the author determined fluorine in drinking water and urine of residents who are divided into four age groups (5, 12, 35-44, 65-74 aged), living in Huangling City, Shaanxi Province and at 6 villages of Qin'an County, Gansu Province, P.R.China. Some residents are living in fluorine exposure areas. A total of 929 residents (463 females and 466 males) involved in the study were selected from 7 tap water systems. Drinking water samples were collected from each area and analyzed using the fluoride ion-selective method. No positive correlation relationship was found between fluorine concentrations in urine and those in drinking water in the area where the fluorine concentrations of drinking water are within the range of 1-2 mg/L. The fluorine absorbed by resistents of different ages is different in amount. With the same concentrations of fluorine in drinking water, more fluorine would be absorbed by young residents than old residents. No difference can be seen in absorption amount of fluorine among different genders. | WANG Binbin ZHENG Baoshan LIAN Weijuan YANG Lan HUANG Ruizhe RUAN Jianping | 2009 | Chinese Journal Of Geochemistry2009，28，2： | 2 |
| 9 | Research on Distributed Data Sharing System based on Internet of Things and Blockchain显示文摘Aiming at the problems of the traditional centralized data sharing platform,such as poor data privacy protection ability,insufficient scalability of the system and poor interaction ability,this paper proposes a distributed data sharing system architecture based on the Internet of Things and blockchain technology.In this system,the distributed consensus mechanism of blockchain and the distributed storage technology are employed to manage the access and storage of Internet of Things data in a secure manner.Up to the physical topology of the network,a hierarchical blockchain network architecture is proposed for local network data storage and global network data sharing,which reduces networking complexity and improves the scalability of the system.In addition,smart contract and distributed machine learning are adopted to design automatic processing functions for different types of data(public or private)and supervise the data sharing process,improving both the security and interactive ability of the system. | Enchang SUN Kang MENG Ruizhe YANG Yanhua ZHANG Meng LI | 2021 | Journal of Systems Science and Information2021，9，3： | 2 |
| 10 | Role of circadian gene Clock during differentiation of mouse pluripotent stem cells显示文摘生理节奏的钟控制的生物节奏在胚胎的干细胞(转换字符) 是不在的。然而,他们开始在 pluripotent 转换字符的区别期间发展到下游的房间。相反地,当他们是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed 时,在成年体的房间的生物节奏消失。这些研究显示在转换字符的生物节奏的发展可能仔细与转换字符的维护和区别被联系。核心生理节奏的基因钟为生物节奏的规定是必要的。它在转换字符的生物节奏的发展的角色完全是未知的。这里,我们使用了 CRISPR/CAS9-mediated 基因编辑技术,完全在鼠标转换字符击倒钟表达式。由染色的 AP, teratoma 形成,量的即时 PCR 和 Immunofluorescent,我们没在 pluripotent 状态下面在形态学和 pluripotent 能力发现钟猛烈 mESCs 和野类型 mESCs 之间的任何差别。简言之,这些数据显示钟没影响维持 pluripotent 状态。然而,他们展出了减少的增长并且增加了 apoptosis。而且,生物节奏没能在自发的区别以后在钟猛烈 mESCs 发展,它显示在以前在老鼠模型描述了的很外部的纸巾没有赔偿因素(DeBruyne 等, 2007b ) 。在自发的区别以后,钟蛋白质的损失由于钟基因 silencing 导致了 mESCs 的自发的区别,显示来自 pluripotent 状态,或它的区分的能力的一个出口。我们的调查结果显示生理节奏的基因钟可以是的核心在由调整 mESCs 增长, apoptosis 和活动的正常 mESCs 区别期间必要。 | Chao Lu Yang Yang Ran Zhao Bingxuan Hua Chen Xu Zuoqin Yan Ning sun Ruizhe Qian | 2016 | Protein & Cell2016，7，11： | 2 |
| 11 | Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer显示文摘 | Ruizhe Shen Shen Pan Shengjian Qi Xiaolin Lin Shidan Cheng | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 2 |
| 12 | Anchoring Single Nickel Atoms on Carbon-vacant Carbon Nitride Nanosheets for Efficient Photocatalytic Hydrogen Evolution显示文摘Polymeric carbon nitride(PCN)has emerged as a promising candidate for photocatalytic hydrogen evolution,but its dependence on scarce and high-cost noble metal co-catalysts severely limits its extensive application.It will be of great promise to develop non-noble metal single-atom co-catalysts with low-cost and high atom utilization to improve the photocatalytic performance over PCN.Herein,single Ni atoms are successfully anchored onto carbon-vacant PCN nanosheets(CCN-SANi)via a two-step ammonia thermal treatment and photo-deposition process.Theoretical calculations and experimental results demonstrate that the optical absorption property and the charge transfer ability of CCN-SANi have been significantly improved with the introduction of single Ni atoms to form Ni-N3 sites.In comparison to carbon-vacant PCN(CCN)loaded with Ni clusters,the obtained CCN-SANi exhibits 11.4 times increased photocatalytic performance,with the highest hydrogen evolution rate reaching 511μmol/(g·h),which is even 1.7 times higher than that of CCN loaded with Pt clusters.This research proposes an inspiring and reliable strategy to design novel single-atom semiconducting polymers with electronic structures manipulated for efficient photocatalysis. | LIN Zhi ZHANG Zhengqi WANG Yiqing PENG Zhiming WANG Xinxin WANG Ruizhe HUANG Yu-Cheng MENG Fanqi LI Mingtao DONG Chung-Li ZHANG Qinghua GU Lin SHEN Shaohua | 2022 | Chemical Research in Chinese Universities2022，38，5： | 1 |
| 13 | Cellulose-based Polymeric Liquid Crystals as a Biomimetic Modifier for Suppressing Protein Adsorption显示文摘A novel biomimetic protein-resistant modifier based on cellulose-based polymeric liquid crystals was described(PLCs). Two types of PLCs of propyl hydroxypropyl cellulose ester(PPC) and octyl hydroxypropyl cellulose ester(OPC) were prepared by esterification from hydroxypropyl cellulose, and then were mixed with polyvinyl chloride and polyurethane to obtain composite films by solution casting, respectively. The surface morphology of PLCs and their composite films were characterized by polarized optical microscopy(POM) and scanning electron microscopy(SEM), suggesting the existence of microdomain separation with fingerprint texture in PLC composite films. Water contact angle measurement results indicated that hydrophilicity of PLC/polymer composite films was dependent on the type and content of PLC as well as the type of matrix due to their interaction. Using bovine serum albumin(BSA) as a model protein, protein adsorption results revealed that PLCs with protein-resistant property can obviously suppress protein adsorption on their composite films, probably due to their flexible LC state. Moreover, all PLCs and their composites exhibited non-toxicity by MTT assay, suggesting their safety for biomedical applications. | 司徒方民 TAN Ruizhe GONG Lei ZHA Zhengang 屠美 ZENG Rong WU Hao ZHANG Jiaqing ZHENG Liheng | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，2： | 1 |
| 14 | Multifaceted Influence of Histone Deacetylases on DNA Damage Repair:Implications for Hepatocellular Carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most commonly diagnosed cancers and a leading cause of cancerrelated mortality worldwide,but its pathogenesis remains largely unknown.Nevertheless,genomic instability has been recognized as one of the facilitating characteristics of cancer hallmarks that expedites the acquisition of genetic diversity.Genomic instability is associated with a greater tendency to accumulate DNA damage and tumor-specific DNA repair defects,which gives rise to gene mutations and chromosomal damage and causes oncogenic transformation and tumor progression.Histone deacetylases(HDACs)have been shown to impair a variety of cellular processes of genome stability,including the regulation of DNA damage and repair,reactive oxygen species generation and elimination,and progression to mitosis.In this review,we provide an overview of the role of HDAC in the different aspects of DNA repair and genome instability in HCC as well as the current progress on the development of HDAC-specific inhibitors as new cancer therapies. | Gan Du Ruizhe Yang Jianguo Qiu Jie Xia | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 1 |
| 15 | Mitochondria-localized iridium(Ⅲ) complexes with anthraquinone groups as effective photosensitizers for photodynamic therapy under hypoxia显示文摘Photodynamic therapy(PDT)is a potential way for the tumor treatment.However,it notably suffers the limitation of hypoxia in solid tumors.Thus,it is significant to develop effective photosensitizers which can exhibit excellent therapeutic performance under both normoxia and hypoxia.Herein,we reported four ionic iridium(Ⅲ)complexes(Irl-Ir4)with anthraquinone groups which can regulate their excited state energy levels effectively.Among them,the energy gap of Ir1 was between 1.63 and 2.21 eV,which can match well with that of O2,and the HOMO energy of Ir1 is less than-5.51 eV.Compared with Ir2-Ir4,the luminescent quantum efficiency of Irl was the highest.Particularly,Ir1 can specifically target the mitochondria of the tumor cells.Meanwhile,Ir1 showed high singlet oxygen quantum yields(Ф△)in both solutions and living cells with low cytotoxicity.The results of PDT experiments revealed that Irl,as a photosensitizer,exhibited excellent therapeutic effect not only in normoxia but also in hypoxia condition.We believe that this work is meaningful for developing excellent PDT agents based on cyclometalated Ir(III)complexes via rational ligand modification. | Song Guo Meiping Han Ruizhe Chen Yanling Zhuang Liang Zou Shujuan Liu Wei Huang Qiang Zhao | 2019 | Science China Chemistry2019，62，12： | 1 |
| 16 | hClock gene expression in human colorectal carcinoma显示文摘 | Liying Wang Bozan Chen Yaping Wang Ning Sun Chao Lu Ruizhe Qian Luchun Hua | 2013 | Molecular Medicine Reports2013，，4： | 1 |
| 17 | Microwave‐assisted preparation of poly(ionic liquids)‐modified magnetic nanoparticles for pesticide extraction显示文摘 | Ruizhe Zhang Ping Su Lu Yang Yi Yang | 2014 | Science2014，，12： | 1 |
| 18 | A load balance optimization framework for sharded-blockchain enabled Internet of Things显示文摘Recently,sharded-blockchain has attracted more and more attention.Its inherited immutabili-ty,decentralization,and promoted scalability effectively address the trust issue of the data sharing in the Internet of Things(IoT).Nevertheless,the traditional random allocation between validator groups and transaction pools ignores the differences of shards,which reduces the overall system per-formance due to the unbalance between computing capacity and transaction load.To solve this prob-lem,a load balance optimization framework for sharded-blockchain enabled IoT is proposed,where the allocation between the validator groups and transaction pools is implemented reasonably by deep reinforcement learning(DRL).Specifically,based on the theoretical analysis of the intra-shard consensus and the final system consensus,the optimization of system performance is formed as a Markov decision process(MDP),and the allocation of the transaction pools,the block size,and the block interval are jointly trained in the DRL agent.The simulation results show that the proposed scheme improves the scalability of the sharded blockchain system for IoT. | 杨兆鑫 YANG Ruizhe LI Meng YU Richard Fei ZHANG Yanhua | 2022 | High Technology Letters2022，28，1： | 1 |
| 19 | Integrating content-based filtering with collaborative filtering using co-clustering with augmented matrices显示文摘 | Wu Menglun Chang Chiahui Liu Ruizhe | 2014 | Expert Systems with Applications2014，41，6： | 1 |
| 20 | Epidural labor analgesia by intrapartum fever clinical analysis显示文摘 | XUE XUAN HOU WENWEN JIA RUIZHE | 2013 | Journal of Nan- jing Medical University : Natural Science Edition2013，39，12： | 1 |
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