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| 1 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 2 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 3 | Regulation of mATG9 trafficking by Src- and ULK1mediated phosphorylation in basal and starvation-induced autophagy显示文摘Autophagy 要求多样的膜来源并且包含 mATG9 的膜 trafficking,在 ATG 家庭的唯一的膜蛋白质。然而,为 autophagy 开始的 mATG9 trafficking 的分子的规定仍然保持不清楚。这里,我们识别了在 mATG9 的 cytosolic N 终点以内排序信号的二保存经典适配器蛋白质,它调停从经由和 AP1/2 建筑群的相互作用的血浆膜和 trans-Golgi 网络(TGN ) 的 mATG9 的 trafficking。在 Tyr8 到的 Src phosphorylates mATG9 处于不着重的条件维持它的 endocytic 和组成的 trafficking。响应饥饿,在由 Src 的 Tyr8 并且在由 ULK1 的 Ser14 的 mATG9 的 phosphorylation 机能上地合作支持在 mATG9 和 AP1/2 建筑群之间的相互作用,为 autophagy 从血浆膜和 juxta 原子的区域导致 mATG9 的再分配到外部水池开始。我们的调查结果揭开 mATG9 trafficking 的新奇机制并且建议基础、导致压力的 autophagy 的协作。 | Changqian Zhou Kaili Ma Ruize Gao Chenglong Mu Linbo Chen Qiangqiang Liu Qian Luo Du Feng Yushan Zhu Quan Chen | 2017 | Cell Research2017，27，2： | 2 |
| 4 | Identification of P1 types and variants of Mycoplasma pneumoniae during an epidemic in Chile 显示文摘 | Martinez MA Ruiz M Zunino E | 2010 | J Med Microbiel2010，59，8： | 1 |
| 5 | Etiology of communi- ty-acquired pneumonia, impact of age, comorbidity, and se- verity显示文摘 | Ruiz M Ewig S Marcos MA | 1999 | Am J Respir Criti Care Med1999，160，2： | 1 |
| 6 | Consequences of resecting the ileocecal union显示文摘 | Jimenez AC Encinas GI Ruiz MA | 1990 | Cir Pediatr1990，3，2： | 1 |
| 7 | Classification and scoring systems in myelodysplastic syndromes: a retrospective analysis of 311 patients 显示文摘 | Navarro I Ruiz MA Cabello A | 2006 | Leuk Res2006，30，8： | 1 |
| 8 | Development of carbonyl iron/ethylcenulose core/shell nanoparticles for biomedical applications显示文摘 | Arias JL Lopez-Viota M Ruiz MA | 2007 | International Journal of Pharmaceutics2007，339，12： | 1 |
| 9 | Flow-through UV spectrophotometric sensor for determination of Salicylic acid in pharmaceutical preparations显示文摘 | Ruiz MA Fernandez ML Ortega BP | 2001 | Int J Pham2001，216，1： | 1 |
| 10 | The growing burden of diabetes mellitus in the US elderly population显示文摘 | Sloan FA Bethel MA Ruiz D Jr | 2008 | Arch Intern Med2008，168，： | 1 |
| 11 | Etiology of communityacquired pneumonia: impact of age, comorbidity, and severity显示文摘 | Ruiz M Ewig S Marcos MA | 1999 | Am J Respir Crit Care Med1999，160，2： | 1 |
| 12 | Effect of flumazenil on recovery after midazolam and propofol sedation显示文摘 | Ghouri AF Ruiz MA White PF | 1994 | Anesthesiology1994，81，2： | 1 |
| 13 | Etiology of community-acquired pneumonia: impact of age, comorbidity,and severity显示文摘 | Ruiz M Ewig S Marcos MA | 1999 | Am J Respir Crit Care Med1999，160，： | 1 |
| 14 | Assessing risk of the use of livers with macro and microste-atosis in a liver transplant program显示文摘 | URENA MA RUIZ -DELGADO FC GONZALEZ EM | 1998 | Transplant Proc1998，30，7： | 1 |
| 15 | Poly(alkyl cyanoacrylate) colloidal particles as vehicles for antitumour drug delivery:a comparative study显示文摘 | José L Arias Ma Adolfina Ruiz Margarita L6pez-Viota | | 0，，01： | 1 |
| 16 | Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy显示文摘 | Ruiz MA Feng B Chakrabarti S | 2015 | PLoS One2015，10，01： | 1 |
| 17 | Interventions for prevention and management of child and youth obesity显示文摘 | Prez Morente MA Sdnchez Oc6n MT Mingorance Ruiz MV | 2015 | Rev Enferm2015，38，2： | 1 |
| 18 | Two-phase scintigraphy with technetium ^99m-sestamibi in patients with hyperparathyroidism due to chronic renal failure显示文摘 | Muros MA Bravo Soto J Lopez Ruiz JM etal | 2007 | Am J Surg2007，193，4： | 1 |
| 19 | Tegafur loading and release properties of magnetite/poly(alkylcyanoacrylate) (core/shell) nanoparticles显示文摘 | Arias JL Ruiz MA Gallardo V | 2008 | Journal of Controlled Release2008，125，1： | 1 |
| 20 | Etiology of community-acquired pneumonia:impact of age,comorbidity,and severity显示文摘 | Ruiz M Ewig S Marcos MA | 1999 | Am J Respir Crit Care Med1999，160，： | 1 |
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