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| 1 | Jurassic Intra-plate Basaltic Magmatism in Southeast China:Evidence from Geological and Geochemical Characteristics of the Chebu Gabbroite in Southern Jiangxi Province显示文摘Geochemical and isotopic investigations have been carried out on the Chebu gabbroite in southern Jiangxi Province, southeast China and these results are compared with gabbro bodies along the coast of Fujian Province in order to understand their magma sources and tectonic implications. The Chebu intrusion formed at the beginning of the Middle Jurassic (172±4.3 Ma). These rocks are Ti-rich and Al-poor in major elements, characterized by strong enrichment in large-ion lithophile elements (LILE) and moderate enrichment in high field strength elements (HFSE) and light rare-earth elements (LREE), without pronounced Nb or Ta anomalies. Age-correlated Sr-Nd isotope ratios show moderately high ranges of (87Sr/86Sr)i from 0.7065 to 0.7086 and 0.5124 to 0.5125 of (143Nd/144Nd)i. The geochemical characteristics of the Chebu gabbroite suggest that it is notably different from island-arc basalt and similar to intra-plate basaltic rocks. By combining interpretations of its geological and geochemical characteristics and the regional geological development history, the Chebu gabbroitic intrusion is thought to be the product of asthenosphere upwelling and rapid lithosphere extension during a transition of tectonic systems in southeast China. The tectonic environment and source characteristics of the intrusion are different from Cretaceous gabbro bodies along the coast of Fujian Province, The former formed in a tectonic environment of rapid intra-plate lithospheric extension and the source characteristics were of a weakly enriched primitive mantle, whereas the latter originated mainly in a volcanic-magmatic arc extensional tectonic environment and the nature of the source was an enriched mantle with more subduct subducted components. | XIE Guiqing MAO Jingwen HU Ruizhong LI Ruiling JIANG Guohao CAO Jinjian ZHAO Junhong | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 10 |
| 2 | Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes显示文摘We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to investigate the unique pharmacological properties of zacopride. The whole-cell patch-clamp technique was used to study IK1 currents in rat atrial myocytes and Kir2.x currents in human embryonic kidney (HEK)-293 cells transfected with inward rectifier potassium channel (Kir)2.1, Kir2.2, Kir2.3, or mutated Kir2.1 (at phosphorylation site S425L). Western immunoblots were performed to estimate the relative protein expression levels of Kir2.x in rat atria and ventricles. Results showed that zacopride did not affect the IK1 and transmembrane potential of atrial myocytes. In HEK293 cells, zacopride increased Kir2.1 homomeric channels by 40.7%±9.7% at 50 mV, but did not affect Kir2.2 and Kir2.3 homomeric channels, and Kir2.1-Kir2.2, Kir2.1-Kir2.3 and Kir2.2-Kir2.3 heteromeric channels. Western immunoblots showed that similar levels of Kir2.3 protein were expressed in rat atria and ventricles, but atrial Kir2.1 protein level was only 25% of that measured in the ventricle. In addition, 5-hydroxytryptamine (5-HT) 3 receptor was undetectable, whereas 5-HT 4 receptor was weakly expressed in HEK293 cells. The Kir2.1-activating effect of zacopride in these cells was abolished by inhibition of protein kinase A (PKA), but not PKC or PKG. Furthermore, zacopride did not activate the mutant Kir2.1 channel in HEK293 cells but selectively activated the Kir2.1 homomeric channel via a PKA-dependent pathway, independent to that of the 5-HT receptor. | ZHANG Li LIU QingHua LIU ChengFang ZHAI XuWen FENG QiLong XU RuiLing CUI XiangLi ZHAO ZhiQing CAO JiMin WU BoWei | 2013 | Science China(Life Sciences)2013，56，9： | 7 |
| 3 | Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic显示文摘In early 2020,the COVID-19 outbreak complicated the diagnosis,treatm ent and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours,such as online gaming disorders,in the general public.Substance use disorder is a chronic recurrent brain disease characterised by strong cravings,high recurrence rates,and a high proportion of comorbidity of mental and physical disorders.1 Therefore,regular long-term therapeutic interventions are critical to preventing dm g relapses while maintaining withdrawal. | Jiang Du Ni Fan Min Zhao Wei Hao Tieqiao Liu Lin Lu Jie Shi Haifeng Jiang Na Zhong Xiaochang Lan Shichao Xu Hongxian Chen Xiaojun Xiang Xuyi Wang Hongqiang Sun Bing Li Yu-Ping Ning Jing Li Wanjun Guo Yajuan Niu Lixia Sheng Yi Li Xuebin Liu Xuhui Zhou Mincai Qian Wenhua Zhou Ruiling Zhang Hongxing Hu Yan Xia Zhonghua Su Ruimin Zhang Mei Yang Fen Liu Wei Yuan | 2020 | General Psychiatry2020，33，4： | 1 |
| 4 | Research Progress of Diseases on Atractylodes lancea显示文摘According to the current situation of diseases on Atractylodes lancea , the etiology, pathogenesis, symptoms and control methods of root diseases, leaf diseases and other diseases of A. lancea are analyzed, in order to provide a reference for the diagnosis and control of diseases on A. lancea . | Ruiling LU Shi CHEN Baosheng DAI Siqi XU Jie WANG Shuang AN Qian ZHAO Zitong ZHAI | 2022 | Plant Diseases and Pests2022，13，6： | 0 |
| 5 | Role of the STAT3/survivin signaling pathway in the EML4-ALK-positive lung adenocarcinoma cell line H2228 before and after crizotinib-induced resistance显示文摘Objective This study investigated the role of the STAT3/survivin signaling pathway in the EML4-ALK–positive lung adenocarcinoma cell line H2228 before and after crizotinib-induced resistance. The mechanism of resistance was studied. Methods Cell viability was determined using the MTT assay. Crizotinib-induced apoptosis in H2228 and H2228 crizotinib-resistant cells treated with the indicated doses of crizotinib was measured at different times(24 h, 48 h, 72 h) using flow cytometry. The levels of p-ALK, ALK, p-STAT3, STAT3, and survivin after treatment of cells with 0, 0.3, and 1 μM crizotinib for 72 h were determined using Western blot analysis. DNA sequencing was used to identify mutations in H2228 crizotinib-resistant cells. Results The crizotinib IC50 values in H2228 and H2228 crizotinib-resistant cells at 72 h were 334.5 n M and 3418 n M, respectively. The resistance index of H2228 crizotinib-resistant cells was 10.20. Crizotinib induced apoptosis in H2228 cells and reduced the levels of p-ALK, p-STAT3, and survivin. In contrast, no changes in the levels of p-ALK, p-STAT3, and survivin were observed in H2228 crizotinib-resistant cells. The mutations 2067G→A and 2182G→C in EML4-ALK were present in the H2228 crizotinib-resistant cells. Conclusion Crizotinib decreased the viability of H2228 cells in a dose- and time-dependent manner. In the STAT3/survivin pathway, downregulation of p-ALK, p-STAT3, and survivin might contribute to crizotinib-induced apoptosis in H2228 cells. However, the STAT3/survivin pathway in H2228 crizotinib-resistant cells was unaffected by crizotinib treatment. Acquired resistance in H2228 cells might be related to ALK mutations. | Haiyan Peng Wenhua Zhao Cuiyun Su Xiangqun Song Aiping Zeng Huilin Wang Ruiling Ning Shaozhang Zhou | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，2： | 0 |
| 6 | In situ rapid versatile method for the preparation of zirconium metal-organic framework filters显示文摘The development of the rapid preparation of highly stable metal-organic framework(MOF)-based devices provides the possibility of meeting the increasing demands of MOF in industrial applications.However,MOFs experience poor processability and stable high-valence-metal(Ⅳ)-based MOFs favor forming either thermodynamically stable metal hydroxides or oxides during their growth and nucleation,which hinders their practical applications.Herein,we present a versatile deep eutectic solvent(DES)-assisted hot pressing method to in situ rapidly prepare six distinct zirconium-based MOF nanocrystals on fibers(denoted as Zr-MOFilters)within 20 min.A small amount of DES promotes MOF precursor contact and accelerates Zr-MOF growth.Temperature and pressure facilitate the formation of Zr-MOFs onto desired substrates.In situ1H nuclear magnetic resonance spectra and time-dependent Fourier-transform infrared spectra were conducted to elucidate the growth of Zr-MOF nanocrystals.As a proof-of-concept,the abilities of Zr-MOFilters for Cr_(2)O_(7)^(2−) and micro(nano)plastics removal have been demonstrated.This strategy paves the way for the rapid fabrication of highly stable MOF-based devices and brings MOFs a step closer to practical application. | Hang Wang Xingmao Zhang Ruxin Yao Shuang Zhao Pengfei Zhao Ruile Yang Lin Wang Yichao Huang Tong Wei Xiang Li Zhuangjun Fan Bo Wang | 2022 | Science China Chemistry2022，65，12： | 0 |
| 7 | The prospect of natural gas hydrate(NGH)under the vision of Peak Carbon Dioxide Emissions in China显示文摘To achieve the goals of Peak Carbon Dioxide Emissions and Carbon Neutrality,China's energy system will continue to accelerate the transition to a clean and low-carbon one.As the cleanest fossil fuel,natural gas is regarded as an inevitable choice for China to build a clean,safe,efficient,and low-carbon energy system and fulfill the goal of“double carbon”.However,the domestic conventional natural gas supply remains rigid while the stimulation of unconventional natural gas is still limited.If we have a firm grip on the principal line of“understanding the ocean–developing resources–ensuring security”to realize the large-scale development of 85 trillion square meters of NGH in the South China Sea,then we could not only greatly reduce China‘s foreign dependence on natural gas,but also guarantee the safety of China‘s natural gas multi-path supply and safeguard the sovereignty of the South China Sea.Thus,the goal of Peak Carbon Dioxide Emissions and Carbon Neutrality can be achieved in no time. | Na Wei Ruiling Bai Jinzhou Zhao Yao Zhang Jin Xue | 2021 | Petroleum2021，7，4： | 0 |
| 8 | Comparison and Analysis of the Major Ingredients of Different Chinese Chestnut Varieties显示文摘[Objectives]This study was conducted to investigate the differences of main nutrient components in 29 different varieties of Chinese chestnut.[Methods]The protein contents,starch contents,Vc contents,soluble sugar contents and inorganic element contents in the 29 different varieties of Chinese chestnut in the north were detected and compared.[Results]The main nutrient components in the 29 varieties of Chinese chestnut were as follows:amylose content 47.16%-63.27%,protein content 3.23%-7.58%,soluble sugar content 7.23%-16.17%,Vc content 2.42-9.42 mg/100 g,Fe content 7.20-17.28 mg/kg,K content 3611-8940 mg/kg,Zn content 4.43-9.24 mg/kg,Ca content 120-304 mg/kg,and P content 752-1658 mg/kg.In general,four varieties,'Dabanhong','Yanbao','Duanzhi'and'Jinhua',have higher nutritional components.[Conclusions]This study provides a theoretical basis for the processing,utilization,storage,purchase,breeding and scientific management of Chinese chestnut in the future. | Lei WANG Yanhua YAN Shouguo GU Liang LI Kai GE Tian LIN Ruiling ZHAO Xueliang PANG | 2022 | Agricultural Biotechnology2022，11，6： | 0 |
| 9 | Cytochrome P450 mono-oxygenase CYP703A2 plays a central role in sporopollenin formation and ms5ms6 fertility in cotton显示文摘The double-recessive genic male-sterile(ms)line ms5 ms6 has been used to develop cotton(Gossypium hirsutum)hybrids for many years,but its molecular-genetic basis has remained unclear.Here,we identified the Ms5 and Ms6 loci through map-based cloning and confirmed their function in male sterility through CRISPR/Cas9 gene editing.Ms5 and Ms6 are highly expressed in stages 7–9 anthers and encode the cytochrome P450 mono-oxygenases CYP703A2-A and CYP703A2-D.The ms5 mutant carries a single-nucleotide C-to-T nonsense mutation leading to premature chain termination at amino acid 312(GhCYP703A2-A^(312aa)),and ms6 carries three nonsynonymous substitutions(D98E,E168K,and G198R)and a synonymous mutation(L11L).Enzyme assays showed that GhCYP703A2 proteins hydroxylate fatty acids,and the ms5(GhCYP703A2-A^(312aa))and ms6(GhCYP703A2-D^(D98E,E168K,G198R))mutant proteins have decreased enzyme activities.Biochemical and lipidomic analyses showed that in ms5 ms6 plants,C12–C18 free fatty acid and phospholipid levels are significantly elevated in stages 7–9 anthers,while stages 8–10 anthers lack sporopollenin fluorescence around the pollen,causing microspore degradation and male sterility.Overall,our characterization uncovered functions of GhCYP703A2 in sporopollenin formation and fertility,providing guidance for creating male-sterile lines to facilitate hybrid cotton production and therefore exploit heterosis for improvement of cotton. | Huanhuan Ma Yuanlong Wu Ruiling Lv Huabin Chi Yunlong Zhao Yanlong Li Hongbo Liu Yizan Ma Longfu Zhu Xiaoping Guo Jie Kong Jianyong Wu Chaozhu Xing Xianlong Zhang Ling Min | 2022 | Journal of Integrative Plant Biology2022，64，10： | 0 |
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