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| 1 | Active disturbance rejection control on first-order plant显示文摘Conventional PI control encounters some problems when dealing with large lag process in the presence of parameter uncertainties.For the typical first-order process,an observerbased linear active disturbance rejection control(LADRC) scheme is presented to cope with the difficulties,and a reduced-order observer scheme is proposed further.Some quantitative dynamic results with regard to non-overshoot characteristics are obtained.Finally,the performance boundaries of LADRC and PI control are explicitly compared with each other,which shows that the former is more superior in most cases. | Ruiguang Yang Mingwei Sun Zengqiang Chen | 2011 | Journal of Systems Engineering and Electronics2011，22，1： | 20 |
| 2 | Knockdown of HMGB1 improves apoptosis and suppresses proliferation and invasion of glioma cells显示文摘Background: Effective methods for managing patients with solitary pulmonary nodules(SPNs) depend critically on the predictive probability of malignancy.Methods: Between July 2009 and June 2011, data on gender, age, cancer history, tumor familial history, smoking status, tumor location, nodule size, spiculation, calcification, the tumor border, and the final pathological diagnosis were collected retrospectively from 154 surgical patients with an SPN measuring 3-30 mm. Each final diagnosis was compared with the probability calculated by three predicted models—the Mayo, VA, and Peking University(PU) models. The accuracy of each model was assessed using area under the receiver operating characteristics(ROC) and calibration curves.Results: The area under the ROC curve of the PU model [0.800; 95% confidence interval(CI): 0.708-0.891] was higher than that of the Mayo model(0.753; 95% CI: 0.650-0.857) or VA model(0.728; 95% CI: 0.623-0.833); however, this finding was not statistically significant. To varying degrees, calibration curves showed that all three models overestimated malignancy.Conclusions: The three predicted models have similar accuracy for prediction of SPN malignancy, although the accuracy is not sufficient. For Chinese patients, the PU model may has greater predictive power.Background: Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas resection.Methods: Ten patients with anterior, middle skull base and sphenoid ridge meningioma were operated using the CUSA Excel ultrasonic aspiration system at the Neurosurgery Department of Shanghai Huashan Hospital from August 2014 to October 2014. There were six male and four female patients, aged from 38 to 61 years old(the mean age was 48.5 years old). Five cases with tumor located at anterior skull base, three cases with tumor on middle skull base, and two cases with tumor on sphenoid ridge.Results: All the patents received total resection of meningiomas with the help of this new tool, and the critical brain vessels and nerves were preserved during operations. All the patients recovered well after operation.Conclusions: This new CUSA Excel ultrasonic aspiration system has the advantage of preserving vital brain arteries and cranial nerves during skull base meningioma resection, which is very important for skull base tumor operations. This key step would ensure a well prognosis for patients. We hope the neurosurgeons would benefit from this kind of technique.Background: The purposes of this study were to explore the effects of high mobility group protein box 1(HMGB1) gene on the growth, proliferation, apoptosis, invasion, and metastasis of glioma cells, with an attempt to provide potential therapeutic targets for the treatment of glioma. Methods: The expressions of HMGB1 in glioma cells(U251, U-87 MG and LN-18) and one control cell line(SVG p12) were detected by real time PCR and Western blotting, respectively. Then, the effects of HMGB1 on the biological behaviors of glioma cells were detected: the expression of HMGB1 in human glioma cell lines U251 and U-87 MG were suppressed using RNAi technique, then the influences of HMGB1 on the viability, cycle, apoptosis, and invasion abilities of U251 and U-87 MG cells were analyzed using in a Transwell invasion chamber. Also, the effects of HMGB1 on the expressions of cyclin D1, Bax, Bcl-2, and MMP 9 were detected. Results: As shown by real-time PCR and Western blotting, the expression of HMGB1 significantly increased in glioma cells(U251, U-87 MG, and LN-18) in comparison with the control cell line(SVG p12); the vitality, proliferation and invasive capabilities of U251 and U-87 MG cells in the HMGB1 siR NA-transfected group were significantly lower than those in the blank control group and negative control(NC) siR NA group(P<0.05) but showed no significant difference between the blank control group and NC siR NA group. The percentage of apoptotic U251 and U-87 MG cells was significantly higher in the HMGB1 siR NA-transfected group than in the blank control group and NC siR NA group(P<0.05) but was similar between the latter two groups. The HMGB1 siR NA-transfected group had significantly lower expression levels of Cyclin D1, Bcl-2, and MMP-9 protein in U251 and U-87 MG cells and significantly higher expression of Bax protein than in the blank control group and NC siR NA group(P<0.05); the expression profiles of cyclin D1, Bax, Bcl-2, and MMP 9 showed no significant change in both blank control group and NC siR NA group. Conclusions: HMGB1 gene may promote the proliferation and migration of glioma cells and suppress its effects of apoptosis. Inhibition of the expression of HMGB1 gene can suppress the proliferation and migration of glioma cells and promote their apoptosis. Our observations provided a new target for intervention and treatment of glioma. | Jing Zhang Cang Liu Ruiguang Hou | 2014 | Chinese Journal of Cancer Research2014，26，6： | 9 |
| 3 | Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism显示文摘To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete. | YANG LiuQi, TAN SiJie, YU HaiJing, ZHENG BingRong, QIAO EnFa, DONG YongLi, ZAN RuiGuang & XIAO ChunJie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China | 2008 | Science China(Life Sciences)2008，51，5： | 7 |
| 4 | Evaluation of self-healing ability of Ce-V conversion coating on AZ31 magnesium alloy显示文摘This study investigated the influence of cerium nitrate in vanadate solutions on the properties of Ce–V conversion coatings on AZ31 magnesium alloys,and evaluated the self-healing behavior of the Ce–V conversion coating for AZ31 magnesium alloy.The results showed that the additions of cerium nitrate prevented pentavalent vanadium from reducing to tetravalent vanadium in the coatings during conversion reaction process.Adding appropriate cerium nitrate to vanadate solution led to a thicker coating with a more compact CeVO_(4) layer.The corrosion behavior of the Ce–V conversion coating was investigated by the electrochemical tests and the scratch immersion test in 3.5 wt.%NaCl solution.The self-healing ability of the coating was confirmed from all tests.The surface analysis revealed that the self-healing effect of the Ce–V conversion coating was only provided by the release and migration of vanadium compounds. | Xiao Jiang Ruiguang Guo Shuqin Jiang | 2016 | Journal of Magnesium and Alloys2016，4，3： | 6 |
| 5 | Microblog Burst Keywords Detection Based on Social Trust and Dynamics Model显示文摘Microblog has emerged as a popular medium for providing new sources of information and rapid communications, particularly during burst topics. Burst keywords detection from real-time microblog streams is important for burst topics detection. The exiting algorithms may detect fake burst keywords without taking into account the trustworthiness of the users and human's daily timetable. Our work is the first to combine the trustworthiness of the users with burst keywords detection. We propose a novel approach to detect burst keywords based on social trust and dynamics model. We adapt basic notions of dynamics from physics and model keywords bursts as momentum change of the keywords. On the analogy of physical dynamics model, this approach defines mass as the trustworthiness of user and position as the frequency of keywords. We compute each keyword's burst value by using Moving average convergence/divergence(MACD) and determine whether it is a burst keyword in a given time window. The experimental results on large-scale Sina microblog dataset show that the proposed approach can avoid detecting fake burst keywords. | DONG Guozhong LI Ruiguang YANG Wu WANG Wei GONG Liangyi SHEN Guowei YU Miao LV Jiguang | 2014 | Chinese Journal of Electronics2014，23，4： | 6 |
| 6 | Simultaneous elimination of T- and B-cell epitope by structure-based mutagenesis of single Glu80 residue within recombinant staphylokinase显示文摘减少 recombinant staphylokinase 的 immunogenicity,在野类型的 staphylokinase (wt-Sak ) 的 Glu80 残余的基于结构的 mutagenesis 讲道理地被设计并且由修改 QuikChange 指导地点的 mutagenesis 执行了。包括 Sak (E80A ) 和 Sak (E80S ) , Sak 异种成功地在 E 被表示。是的 coli DH5 一可溶的细胞质的蛋白质并且占了超过 40% 全部的细胞的蛋白质。表示蛋白质被一个三步的色析法的纯化过程净化。SDSPAGE 和 HPLC 分析结果显示净化的蛋白质是几乎完全同类的, Sak 异种的纯净超过了 97% 。fibrinolytic 活动的分析表明有丝氨酸和丙氨酸的 E80 残余的替换导致了 Sak 异种的稍微增加的特定的活动。Sak 异种的 immunogenicity 的调查证明特定的 anti-Sak IgG 抗体的数量由 Sak (E80A ) 得到了,在 BALB/c 老鼠的 Sak (E80S ) 减少了 35% 和 27% ,分别地与 wt-Sak 相比。Sak 异种的能力显著地 wt-Sak 比那些降低从 BALB/c 老鼠刺激 T 房间的增长并且绑 polyclonal 浆液是的老鼠 anti-Sak。这些结果建议由丙氨酸和丝氨酸的 Glu80 残余的替换成功地消除了 T 房间的部分和 Sak 分子的 B 房间 epitope。我们的调查结果建议 T 房间和 B 房间 epitopes 的那同时的消除是一个有用方法减少 wt-Sak 分子的 immunogenicity 并且为为尖锐心肌的梗塞的临床的处理设计安全基于 Sak 的 fibrinolytics 提供了策略。 | Jintian He Ruiguang Xu Xi Chen Kai Jia Xianglian Zhou Ke Zhu | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 3 |
| 7 | WAF-Based Chinese Character Recognition for Spam Image Filtering显示文摘We address the problem of filtering image spam, a kind of rapidly spread spam in which the text is embedded into images to defeat text-based spam filter.Particularly, we focus on image spam with Chinese text as 'spam' which is a more challenging task. A popular way to detect image spam is by Optical character recognition(OCR) system, which detects and recognizes the embedded text, then followed by a text classifier that discriminate spam from ham. However, spammers start to obscure image text to prevent OCR system discovering the spam text. To compensate for the shortcomings of OCR system, a novel method which essentially is a keyword reconstruction algorithm based on Word activation force(WAF) model is proposed. It is effective on discovering keywords, hence is benefit for the later classification stage and notably improve the performance of image spam filtering. The experimental results on a personal data set of spam images(publicly available) validate the effectiveness of our approach that outperforms the original OCR system in practical usage with complex background in image spam. | LI Siyuan LI Ruiguang XU Yuan ZHOU Hao YAN Hanbing XU Bin ZHANG Honggang | 2018 | Chinese Journal of Electronics2018，27，5： | 3 |
| 8 | Filtering Chinese Image Spam Using Pseudo-OCR显示文摘For image spam filtering, the Optical character recognition(OCR) based methods often achieve a better performance due to the more complex structure of recognizing corresponding text. However, applying traditional OCR techniques usually introduced shortcomings like the expensive computational cost, vulnerability to image noises and artificial interferences, especially for Chinese image spam filtering. So, by optimizing recognition procedure of traditional OCR, we propose the idea of pseudo-OCR more suitable for Chinese image spam filtering. During which discriminating the potential image spam character features from ham ones is sufficient, instead of recognizing them. What's more, a novel Chinese key-point based character feature specific for pseudo-OCR is also devised and extracted using a carefully designed algorithm, which outperforms classic corner detection methods in finding such key-points. Experiment results show that our proposed system usually has a better performance than traditional OCR based method while maintaining a low false positive rate. | XU Bin LI Ruiguang LIU Yashu YAN Hanbing LI Siyuan ZHANG Honggang | 2015 | Chinese Journal of Electronics2015，24，1： | 2 |
| 9 | Optimizing the operation of the Qingshitan Reservoir in the Lijiang River for multiple human interests and quasi-natural flow maintenance显示文摘For reservoir operation, maintaining a quasi-natural flow regime can benefit river ecosystems, but may sacrifice human interests. This study took the Qingshitan Reservoir in the Lijiang River as a case, and developed an optimization model to explore a trade-off solution between social-economic interests and nature flow maintenance on a monthly base. The objective function considered irrigation, cruise navigation and water supply aspects. An index of flow alteration degree was proposed to measure the difference between the regulated discharge and the natural flow. The index was then used as an additional constraint in the model besides the conventional constraints on reservoir safety. During model solving, different criteria were applied to the index, representing various degrees of alteration of the natural flow regime in the river. Through the model, a relationship between social-economic interests and flow alteration degree was established. Finally, a trade-off solution of the reservoir operation was defined that led to a favorable social-economic benefit at an acceptable alteration of the natural flow. | Qiuwen Chen Duan Chen Ruiguang Han Ruonan Li Jinfeng Ma Koen Blanckaert | 2012 | Journal of Environmental Sciences2012，24，11： | 2 |
| 10 | Bacterial Phosphoproteomic Analysis Reveals the Correlation Between Protein Phosphorylation and Bacterial Pathogenicity显示文摘Increasing evidence shows that protein phosphorylation on serine, threonine and tyrosine residues is a major regulatory post-translational modification in the bacteria. This review focuses on the implications of bacterial phosphoproteome in bacterial pathogenicity and highlights recent development of methods in phosphoproteomics and the connectivity of the phosphorylation networks. Recent technical developments in the high accuracy mass spectrometry have dramatically transformed proteomics and made it possible the characterization of a few exhaus- tive site-specific bacterial phosphoproteomes. The high abundance of tyrosine phosphorylations in a few bacterial phosphoproteomes suggests their roles in the pathogenicity, especially in the case of pathogen-host interactions; the high abundance of multi-phosphorylation sites in bacterial phosphoprotein is a compensation of the relatively small phosphorylation size and an indicator of the delicate regulation of protein functions. | Ruiguang Ge Weiran Shan | 2011 | Genomics, Proteomics & Bioinformatics2011，9，4： | 2 |
| 11 | Back-analysis of viscoelastic displacements in a soft rock road tunnel显示文摘 | Yang Zhifa Wang Zhiyin Zhang Luqing Zhou Ruiguang Xing Nianxing | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，，3： | 1 |
| 12 | The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori : Linking gastric and Alzheimer’s diseases together?显示文摘 | Ruiguang Ge Xuesong Sun | 2011 | Medical Hypotheses2011，，5： | 1 |
| 13 | Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells显示文摘 | Ruiguang Ge Xuesong Sun Dongxian Wang Qinglu Zhou Hongzhe Sun | 2011 | BBA - Molecular Cell Research2011，，8： | 1 |
| 14 | Phase diagram of stigmasterol- dipalmitoylphosphatidylcholine mixtures dispersed in excess water 显示文摘 | Wu Ruiguang Chen Lin Yu Zhiwu | 2006 | Biochim Biophys Acta2006，1758，6： | 1 |
| 15 | Phenol hydroxylation over Fe-incorporated mesoporous materials prepared by coprecipitation显示文摘 | LIANG Xiuli YANG Ruiguang LI Guiying | 2013 | Microporous and Mesoporous Materials2013，182，： | 1 |
| 16 | ADRC control onfirst -order plant显示文摘 | Yang Ruiguang Sun Mingwei | 2011 | Journal of system engineering and e- lectronics2011，25，1： | 1 |
| 17 | Reduction of ro- tor loss in high - speed permanent magnet motors by design method 显示文摘 | ZHOU Fengzheng SHEN Jianxin LIN Ruiguang | 2007 | Journal of Zhejiang University : Engineering Science2007，，： | 1 |
| 18 | Phase diagram of stigmas- terol- dipalmitoylphosphatidylcholine mixtures dispersed in excess water显示文摘 | Wu Ruiguang Chen Lin Yu Zhiwu | 2006 | Biochim Biophys Acta2006，1758，6： | 1 |
| 19 | Fluorocarbon paint on Daya Bay antineutrino detectors显示文摘The aim of the Daya Bay reactor antineutrino experiment is to determine the neutrino mixing angle 13 with a sensitivity of 0.01 or better at 90% confidence level.In order to improve the position resolution of both the positron interaction and the neutron capture,the inside of the antineutrino detectors should be as unreflecting as possible.A black matt fluorocarbon paint is coated on the inner surface of the detectors made of 304L stainless steel to meet the physical requirement.This paint is compatible with mineral oil,has low radioactivity,is easy to spray and fast curing at normal temperatures.The coating has excellent performance such as good adhesive force,uniformity,compact,scratch and wear resistance,and so on.It is the first application of such paint to large physical devices. | WANG RuiGuang HENG YueKun WANG Lan DING YaYun CAO Jun WANG YiFang YANG ChangGen | 2012 | Science China(Technological Sciences)2012，55，6： | 1 |
| 20 | Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-β induction显示文摘 | Xibao Shi Li Wang Xuewu Li Gaiping Zhang Junqing Guo Dong Zhao Shujun Chai Ruiguang Deng | 2011 | Molecular Immunology2011，，12： | 1 |
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