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| 1 | Caveolin-1-deficient fibroblasts promote migration,invasion,and stemness via activating the TGF-β/Smad signaling pathway in breast cancer cells显示文摘Cancer-associated fibroblasts(CAFs)represent one of the main components in the tumor stroma and play a key role in breast cancer progression.Transforming growth factor-β(TGF-β)has been established to mediate breast cancer metastasis by regulating the epithelial-mesenchymal transition(EMT)and stemness of cancer cells.Caveolin-1(CAV-1)is a scaffold protein of caveolae that is related to the proliferation and metabolism of cancer cells.It is now well demonstrated that CAV-1 deficiency in the tumor stroma is positively correlated with distant metastasis,but the mechanism remains unclear.Here,we explore whether CAV-1-deficient fibroblasts play an essential role in the EMT and stemness of breast cancer cells(BCCs)through TGF-βsignaling.We establish a specific small interfering RNA(siRNA)to inhibit CAV-1 expression in fibroblasts and coculture them with BCCs to investigate the effect of CAV-1-deficient fibroblasts and the tumor microenvironment on breast cancer progression.This study refreshingly points out that CAV-1 deficiency in fibroblasts enhances TGF-β1 secretion and then activates the TGF-β1/Smad signaling pathway of BCCs,thus promoting the metastasis and stemness of BCCs.Collectively,our findings indicate an unexpected role of CAV-1 deficiency in fibroblasts and the tumor microenvironment as a permissive factor,which is regulated by the TGF-β1 signaling pathway in BCCs. | Qingyun Huang Longyuan Wu Yi Wang Xinyu Kong Xinhua Xiao Qiyuan Huang Miao Li Yujia Zhai Fuxiu Shi Ruichen Zhao Junpei Zhong Lixia Xiong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 2 | Can urban forests provide acoustic refuges for birds?Investigating the influence of vegetation structure and anthropogenic noise on bird sound diversity显示文摘As a crucial component of terrestrial ecosystems,urban forests play a pivotal role in protecting urban biodiversity by providing suitable habitats for acoustic spaces.Previous studies note that vegetation structure is a key factor influencing bird sounds in urban forests;hence,adjusting the frequency composition may be a strategy for birds to avoid anthropogenic noise to mask their songs.However,it is unknown whether the response mechanisms of bird vocalizations to vegetation structure remain consistent despite being impacted by anthropogenic noise.It was hypothesized that anthropogenic noise in urban forests occupies the low-frequency space of bird songs,leading to a possible reshaping of the acoustic niches of forests,and the vegetation structure of urban forests is the critical factor that shapes the acoustic space for bird vocalization.Passive acoustic monitoring in various urban forests was used to monitor natural and anthropogenic noises,and sounds were classified into three acoustic scenes(bird sounds,human sounds,and bird-human sounds)to determine interconnections between bird sounds,anthropogenic noise,and vegetation structure.Anthropogenic noise altered the acoustic niche of urban forests by intruding into the low-frequency space used by birds,and vegetation structures related to volume(trunk volume and branch volume)and density(number of branches and leaf area index)significantly impact the diversity of bird sounds.Our findings indicate that the response to low and high frequency signals to vegetation structure is distinct.By clarifying this relationship,our results contribute to understanding of how vegetation structure influences bird sounds in urban forests impacted by anthropogenic noise. | Zezhou Hao Chengyun Zhang Le Li Bing Sun Shuixing Luo Juyang Liao Qingfei Wang Ruichen Wu Xinhui Xu Christopher A.Lepczyk Nancai Pei | 2024 | Journal of Forestry Research2024，35，2： | 0 |
| 3 | A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments显示文摘Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate diseases.Numerous studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory pathway.Therefore,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease treatments.Considering the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease treatments.The STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted microglia.The results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s disease.Herein,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies. | Yanyue Wu Wenli Wang Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang Tianlu Zhang Jun Yang Xin Zhang | 2023 | Nano Research2023，16，5： | 0 |
| 4 | Establishment of a method for the determination of hydrogen sulfide in human serum by liquid chromatography-tandem mass spectrometry and evaluation of its clinical application显示文摘Hydrogen sulfide(H2S)is an inorganic compound.It is a colorless,water-soluble gas that results in the smell of rotten eggs.Hydrogen sulfide is the third most important endogenous gas signaling molecule after nitric oxide,NO,and carbon monoxide(CO)[1].Hydrogen sulfide is involved in many physiological and pathological processes.Relevant studies have shown that hydrogen sulfide is widely distributed in the cardiovascular,nervous,digestive,endocrine,and immune systems. | Chunyan Li Jia Chen Yu Su Wuzheng Liu Xiangyu Meng Ao Zhang Yitong Bai Yingzi Liu Ruichen Liu Lin Zhang Jun Wu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，3： | 0 |
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