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| 1 | TRICHOMEAND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua显示文摘毛状体,许多植物种类的表面上的小伸出,能生产并且存储各种各样的第二等的新陈代谢的产品。Artemisinin,最著名并且为疟疾的有势力药,被综合,存储,并且由 Artemisia annua 毛状体藏匿了。然而,糟糕在 A.annua 遗体调整 artemisinin 的生合成和毛状体的发展的分子的基础理解。这里,我们报导那一个 AP2 抄写因素,毛状体和 ARTEMISININ 管理者 1 (TAR1 ) ,在在 A.annua 调整毛状体的发展和 artemisinin 的生合成起关键作用。TAR1,编码特殊位于原子核的蛋白质,主要在年轻叶子,花芽,和一些毛状体被表示。在 TAR1-RNAi 线,毛状体的形态学和表皮的蜡的作文被改变,并且 artemisinin 内容戏剧性地被减少它能被 TAR1 oeverexpression 显著地增加。当 TAR1 是 silenced 或 overexpressed 时,涉及 artemisinin 生合成的几关键基因的表示层次被改变。由 electrophoretic 活动性移动,酵母一个混血儿和短暂转变 -glucuronidase 试金,我们证明广告和 CYP71AV1,在 artemisinin 的生合成小径的二关键基因,是可能的 TAR1 的直接目标。一起拿,我们的结果显示 TAR1 是在 A.annua 调整毛状体开发和 artemisinin 生合成的分子的网络的一个关键部件。 | Hexin Tan Ling Xiao Shouhong Gao Qing Li Junfeng Chen Ying Xiao Qian Ji Ruibing Chen Wansheng Chen Lei Zhang | 2015 | Molecular Plant2015，8，9： | 37 |
| 2 | Surveying of the deformed terraces and crust shortening rate in the northwestern Tarim Basin显示文摘Relief surveying and chronology study were carried out on the deformed river terraces across the Artushi anticline belt in the northwestern Tarim Basin. The crust shortening rate of this anticline belt since late Pleistocene was calculated to be up to 5-6 mm/a. The total crust shortening rate from the northwestern Tarim Basin to southwestern Tianshan since late Pleistocene was estimated to be over 10 mm/a. | SHEN Jun WANG Yipeng ZHAO Ruibing LI Jun D.Burbank K.Share | 2001 | Chinese Science Bulletin2001，46，12： | 13 |
| 3 | A Study of the Characteristics of Microorganisms for Effective Degradation of Marine Oil Spills显示文摘Four microorganism strains were isolated from coastal petroleum-polluted soil and sand samples of Bohai Sea oilfield; they were found to degrade marine oil spills effectively. The experimental results show that the degradation efficiency of crude oil with these four strains (XT-4, SZ-1-25, B-4-9, BS-3-12) is 95.97%, 96.01%, 97.99% and 98.99%, respectively, in their optimum conditions. The characteristics of bacterial biodegradation are investigated. The simulation biotreatment of oil-contaminated beach sand, with an initial oil content of 5,664mg/kg-dry-sand, shows that the residual oil content is 2,700 mg/kg-dry-sand and 2,679 mg/kg-dry-sand after 170 days’ treatment with two bacteria (B-4-9, BS-3-12), respectively. | Zhang Zhongzhi Wei Xiaofang Zong Chang Yu Hongwen Li Chengjian He Ruibing | 2006 | Petroleum Science2006，3，1： | 6 |
| 4 | Efficient Extraction of Lithium Ions from High Mg/Li Ratio Brine through the Synergy of TBP and Hydroxyl Functional Ionic Liquids显示文摘of main observation and conclusion The extraction of Li^+from the high Mg/Li ratio brine was performed using hydroxyl functional ionic lic-uids(ILs)as the coextractant and tributyl phosphate(TBP)as the extractant.irsty the extractive system,1-2-hydroxyethyl-3-mnethylimidazolumbis(trifuoromethylsulfonyl)imide([HOEmim][NTf2])+TBP was proved to exhibit the highest extraction efficiency of Li^+(88.15%)from LiCl aqueous solutions among the extractants composed of differents TB P,and ls+TBP.Effects of various extraction parameters on the extraction eficiencies of Li^+and Mg^2+were then investigated.95.01%of Li^+was extracted and the Li^+/Mg^2+separation factor reached 405.76 in a singl-stage at 278.15 Kand O/A of 2:1.The extraction complexes were determined by the slope analysis method and ESI-MS analysis,and the metal complexes in the organic phase were indcated to be mainly[L-2TBP][NTf;J.The striping study showed that 92.86%of i*was stripped with 1.0 mol·L^-1 HCl.98%extraction capacity of the synergyextractants was remained after 5 regeneration cycles.The thermodynamic parameters(△G°,△H°,and△S°),together with the mechanism of the Li^+extraction were further demonstrated finally,According to the results,[HOEmim][NTf2]+TBP extraction system showed promising performance in extracting lithium from salt lake brine with high Mg/Li ratio. | Ruibing Bai Junfeng Wang Li Cui Shicheng Yang Wei Qian Penglei Cui Yanqiang Zhang | 2020 | Chinese Journal of Chemistry2020，38，12： | 4 |
| 5 | Intramedullary schwannoma of the upper cervical spinal cord:a case study of identification in pathologic autopsy显示文摘Intramedullary schwannoma of the upper cervical spinal cord is rarely reported in forensic medicine.We herein report a case involving a patient who died of compression from an intramedullary schwannoma in the upper cervical spinal cord.A 30-year-old man initially presented with a five-day history of pain in the left chest that progressed to weakening in the left arm.Although the patient was treated with analgesic poultices,he developed inspiratory dyspnoea and died while working the next day without having undergone any medical imaging examination or surgical treatment.Anatomical and histopathological examinations revealed an intramedullary schwannoma in the left cervical spinal cord(C_(3)-C_(5))underneath the spinal nerve root.The cause of death might have been asphyxia secondary to the tumour,which interfered with the nerve function in the respiratory muscles.This finding suggests that an autopsy is essential for pathologists and medicolegists to comprehensively undertake their due obligation to obtain“the first evidence”,especially when there is a lack of directly related evidence.As part of the central nervous system,the spinal cord could be systematically included in a routine pathological autopsy in some cases. | Xianxian Li Guangtao Xu Ruibing Su Junyao Lv Xiaoping Lai Xiaojun Yu | 2017 | Forensic Sciences Research2017，2，1： | 2 |
| 6 | pH-Responsive supramolecular DOX-dimer based on cucurbit[8]uril for selective drug release显示文摘A supramolecular dimer of doxorubicin(DOX)was constructed via ternary host-guest interactions between cucurbit[8]uril(CB[8])and tryptophan modified DOX(DOX-Trp,connected with an acid-labile bond)and we demonstrate for the first time that a supramolecular dimer of DOX can be formed upon homo-dimerization by CB[8],which may act as a stimuli pH-responsive,supramolecular DOX dimer prodrug system.This supramolecular DOX dimer transported DOX efficiently and selectively to cancer cells,thereby exhibiting significantly minimized cytotoxicity against noncancerous cells while maintaining effective cytotoxicity against cancer cells.Under this strategy,many other anticancer drugs could be chemically modified and loaded as a dimeric'ammunition'into CB[8]as supramolecular dimer prodrug systems(or a'jet fighter')for improved cancer therapy. | Qian Cheng Shengke Li Yanlong Ma Hang Yin Ruibing Wang | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 7 | Survivin反义寡核苷酸对宣威肺腺癌细胞凋亡的影响(英文)显示文摘Objective:The aim of the study was to investigate the effects of Survivin antioligonucleotide on the proliferation,apoptosis and cell cycle of Xuanwei lung adenocarcinoma cell XWLC-05.Methods:Specific targeting Survivin ASODN was composed firstly.XWLC-05 would be divided into 4 groups:Group Sham(blank),Group Lip(simple liposome),Group Lip-SODN(transfected sense oligonucleotide) and Group Lip-ASODN(transfected ASODN).All groups had been transfected under the same condition for 48 hours.Then West blotting was used to check the expression of Survivin in cells from different groups and flow cytometer was used to find out the apoptosis rate of cells in different groups.Results:The expression of XWLC-05 Survivin in Group Lip-ASODN decreased obviously and apoptosis rate was significantly higher than that of other groups(P < 0.05).Conclusion:XWLC-05 transfected by Survivin ASODN could down regulate the expression of Survivin and lower expression of Survivin might lead to the apoptosis of XWLC-05 and restrain the proliferation of cancer cells. | Weiwei Wang Gaofeng Li Zhipeng Hong Ruibing Cheng Jipeng Zhang Lianhua Ye | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，5： | 1 |
| 8 | Pattern of cerebrovascular atherosclerotic stenosis in older Chinese patients with stroke显示文摘 | Fang Yang Ling Liu Min Li Mingquan Li Qin Yin Ruibing Guo Yun Li Guanghui Chen Renliang Zhang Xinfeng Liu | 2013 | Journal of Clinical Neuroscience2013，，7： | 1 |
| 9 | Design and development of the deep-rock in-situ condition-preserved coring calibration platform显示文摘To systematically validate and calibrate the theory and technology of the deep in-situ conditionpreserved coring, the in-situ conditions at different depths should be simulated, and the full-size coring tests should be carried out in this simulated environment. Therefore, a deep-rock in-situ conditionpreserved coring calibration platform was designed and developed. The self-tightening sealing structure and the quick-disassembly structure were designed on the basis of an innovative segmented nonuniformdiameter structure, which was a breakthrough from the traditional high-pressure vessel frame and was verified by finite element simulation and actual testing under extreme working conditions, respectively.To simulate the actual deep in-situ environment with a temperature of 150℃ and pressure of 140 MPa for a large Φ450 mm×H1400 mm core, temperature and pressure control systems were designed by coupling, and a pre-embedded high-pressure-resistant temperature sensor was designed. Finally, highprecision assembly automation, complex movement coordination of the coring device with the platform,and rotary dynamic sealing were achieved by utilizing the combination of adaptive cabin body servo control and an adaptive mechanical structure in a limited space, laying a solid foundation for the calibration of in-situ condition-preserved coring. | Yihang Li Heping Xie Ru Zhang Zetian Zhang Zhilong Zhang Heng Gao Wei Huang Jixun Zhang Jiming Gao Xin Ma Ruibing Xu | 2023 | International Journal of Mining Science and Technology2023，33，11： | 1 |
| 10 | Determination of the active constituents in Arnebia euchroma (Royle) Johnst. by ionic liquid-based ultrasonic-assisted extraction high-performance liquid chromatography显示文摘 | Yao Xiao Ying Wang Shiqian Gao Rui Zhang Ruibing Ren Na Li Hanqi Zhang | 2011 | Journal of Chromatography B2011，，20： | 1 |
| 11 | Position Encoding Based Convolutional Neural Networks for Machine Remaining Useful Life Prediction显示文摘Accurate remaining useful life(RUL)prediction is important in industrial systems.It prevents machines from working under failure conditions,and ensures that the industrial system works reliably and efficiently.Recently,many deep learning based methods have been proposed to predict RUL.Among these methods,recurrent neural network(RNN)based approaches show a strong capability of capturing sequential information.This allows RNN based methods to perform better than convolutional neural network(CNN)based approaches on the RUL prediction task.In this paper,we question this common paradigm and argue that existing CNN based approaches are not designed according to the classic principles of CNN,which reduces their performances.Additionally,the capacity of capturing sequential information is highly affected by the receptive field of CNN,which is neglected by existing CNN based methods.To solve these problems,we propose a series of new CNNs,which show competitive results to RNN based methods.Compared with RNN,CNN processes the input signals in parallel so that the temporal sequence is not easily determined.To alleviate this issue,a position encoding scheme is developed to enhance the sequential information encoded by a CNN.Hence,our proposed position encoding based CNN called PE-Net is further improved and even performs better than RNN based methods.Extensive experiments are conducted on the C-MAPSS dataset,where our PE-Net shows state-of-the-art performance. | Ruibing Jin Min Wu Keyu Wu Kaizhou Gao Zhenghua Chen Xiaoli Li | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，8： | 1 |
| 12 | Reviving chloroquine for anti-SARS-CoV-2 treatment with cucurbit[7]uril-based supramolecular formulation显示文摘The wide-spreading SARS-CoV-2 virus has put the world into boiling water for more than a year,however pharmacological therapies to act effectively against coronavirus disease 2019(COVID-19)remain elusive.Chloroquine(CQ),an antimalarial drug,was found to exhibit promising antiviral activity in vitro and in vivo at a high dosage,thus CQ was approved by the FDA for the emergency use authorization(EUA)in the fight against COVID-19 in the US,but later was revoked the EUA status due to the severe clinical toxicity.Herein,we show that supramolecular formulation of CQ by a macrocyclic host,curcurbit[7]uril(CB[7]),reduced its non-specific toxicity and improved its antiviral activity against coronavirus,working in synergy with CB[7].CB[7]was found to form 1:1 host-guest complexes with CQ,with a binding constant of$104 L/mol.The CQ-CB[7]formulation decreased the cytotoxicity of CQ against Vero E6 and L-02 cell lines.In particular,the cytotoxicity of CQ(60 mmol/L)against both Vero E6 cell line and L-02 cell lines was completely inhibited in the presence of 300 mmol/L and 600 mmol/L CB[7],respectively.Furthermore,the CB[7]alone showed astonishing antiviral activity in SARS-CoV-2 infected Vero E6 cells and mouse hepatitis virus strain A59(MHV-A59)infected N2 A cells,and synergistically improved the antiviral activity of CQ-CB[7],suggesting that CB[7]-based CQ formulation has a great potential as a safe and effective antiviral agent against SARS-CoV-2 and other coronavirus. | Cheryl H.T.Kwong Jingfang Mu Shengke Li Yaohui Fang Qianyun Liu Xiangjun Zhang Hiotong Kam Simon M.Y.Lee Yu Chen Fei Deng Xi Zhou Ruibing Wang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 13 | The ERF transcription factor LTF1 activates DIR1 to control stereoselective synthesis of antiviral lignans and stress defense in Isatis indigotica roots显示文摘Lignans are a powerful weapon for plants to resist stresses and have diverse bioactive functions to protect human health.Elucidating the mechanisms of stereoselective biosynthesis and response to stresses of lignans is important for the guidance of plant improvement.Here,we identified the complete pathway to stereoselectively synthesize antiviral(-)-lariciresinol glucosides in Isatis indigotica roots,which consists of three-step sequential stereoselective enzymes DIR1/2,PLR,and UGT71B2.DIR1 was further identified as the key gene in respoJanuary 2024nse to stresses and was able to trigger stress defenses by mediating the elevation in lignan content.Mechanistically,the phytohormone-responsive ERF transcription factor LTF1 colocalized with DIR1 in the cell periphery of the vascular regions in mature roots and helped resist biotic and abiotic stresses by directly regulating the expression of DIR1.These systematic results suggest that DIR1 as the first common step of the lignan pathway cooperates with PLR and UGT71B2 to stereoselectively synthesize(-)-lariciresinol derived antiviral lignans in I.indigotica roots and is also a part of the LTF1-mediated regulatory network to resist stresses.In conclusion,the LTF1-DIR1 module is an ideal engineering target to improve plant Defenses while increasing the content of valuable lignans in plants. | Ruibing Chen Jian Yu Luyao Yu Liang Xiao Ying Xiao Junfeng Chen Shouhong Gao Xianghui Chen Qing Li Henan Zhang Wansheng Chen Lei Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 14 | Survivin-ASODN靶向治疗XWLC-50细胞移植瘤裸鼠的实验研究(英文)显示文摘Objective:The aim of this study was to study the inhibiting effect of survivin mRNA on transplanted XWLC-05 tumor on nude mice.Methods:We established XWLC-05 transplanted nude mice model.44 mice would be divided randomly into 4 groups:control group (blank),Lip group (simple liposome),survivin SODN group (transfected by sense oligonucleotide) and survivin ASODN group (transfected by antisense oligonucleotide).We would study general activities of nude mice in these 4 groups,measure the size of tumor and calculate the tumor inhabiting rate also.Pathological methods were applied in the analysis of the effect of different treatment on heart,kidney and liver of nude mice in these 4 groups.Results:Tumor grew slowly and size,weight of tumor was lower in survivin ASODN group when compared with that of others.Nude mice of survivin ASODN group showed lower growth index and tumor inhabiting rate was significantly higher than that of other groups (P < 0.05).Transplanted tumor on nude mice in control group (blank),Lip group,and survivin SODN group grew bigger as time passed and there was no significance among them (P > 0.05).We found a great deal of tumor cell necrosis in survivin ASODN group.No death of nude mice was observed in all 4 groups and we did not found obvious lesion in vital organs.Conclusion:Survivin ASDON could be used for the inhibitation of subcutaneously transplanted tumor in nude mice without obvious lesion in vital organs. | Weiwei Wang Shaojia Wang Gaofeng Li Lei Li Ruibing Cheng | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
| 15 | Near-Optimal Transmission Optimization of Cache-Based SVC Vehicle Video显示文摘A problem of video streaming of scalable video coding(SVC)is studied in vehicular networks.To improve the performance of the video streaming services and alleviate the pressure on backhaul links,the small cell base stations(SBS)is proposed with caching ability to assist the content delivery.In this paper,it introduced the problem of joint optimization of caching strategy and transmission path in SBS cache cluster.An integer programming problem was formulated to maximize the average quality of experience.In order to obtain the globally optimal solution,the primal problem was first relaxed,then an adaptive algorithm was used based on the joint KKT condition,and the branch definition algorithm was applied.Extensive simulations were performed to demonstrate the efficiency of our proposed caching strategy. | Xianlang Hu He Dong Xiangrui Kong Ruibing Li Guangsheng Feng Hongwu Lv | 2020 | 国际计算机前沿大会会议论文集2020，，1： | 0 |
| 16 | Japanese Encephalitis Virus NS2B-3 Protein Complex Promotes Cell Apoptosis and Viral Particle Release by Down-Regulating the Expression of AXL显示文摘Japanese encephalitis virus(JEV) is a flavivirus transmitted by mosquitoes that causes severe encephalitis in humans and animals. It has been suggested that AXL, a transmembrane protein, can promote the replication of various flaviviruses,such as dengue(DENV), Zika(ZIKV), and West Nile(WNV) viruses. However, the effect of AXL on JEV infection has not yet been determined. In the present study, we demonstrate that AXL is down-regulated after JEV infection in the late stage. JEV NS2B-3 protein specifically interacted with AXL, and promoted AXL degradation through the ubiquitin–proteasome pathway. AXL-degradation increased cell apoptosis by disrupting phosphatidylinositol 3-kinase(PI3 K)/Akt signal transduction. In addition, the degradation of AXL promoted JEV release to supernatant, whereas the virus in the cell lysates decreased. The supplementation of AXL ligand Gas6 inhibited the JEV-mediated degradation of AXL. Altogether,we discover a new function of NS2B-3 during the process of JEV replication, and provide a new insight into the interactions between JEV and cell hosts. | Shengda Xie Zhenjie Liang Xingmiao Yang Junhui Pan Du Yu Tongtong Li Ruibing Cao | 2021 | Virologica Sinica2021，36，6： | 0 |
| 17 | PGAM5-Mediated PHB2 Dephosphorylation Contributes to Diabetic Cardiomyopathy by Disrupting Mitochondrial Quality Surveillance显示文摘Disruption of the mitochondrial quality surveillance(MQS)system contributes to mitochondrial dysfunction in diabetic cardiomyopathy(DCM).In this study,we observed that cardiac expression of phosphoglycerate mutase 5(PGAM5),a mitochondrial Ser/Thr protein phosphatase,is upregulated in mice with streptozotocin-induced DCM.Notably,DCM-related cardiac structural and functional deficits were negated in cardiomyocyte-specific Pgam5 knockout(Pgam5^(CKO))mice.Hyperglycemic stress impaired adenosine triphosphate production,reduced respiratory activity,and prolonged mitochondrial permeability transition pore opening in acutely isolated neonatal cardiomyocytes from control Pgam5^(f/f) mice,and these effects were markedly prevented in cardiomyocytes from Pgam5^(CKO) mice.Likewise,three main MQS-governed processes—namely,mitochondrial fission/fusion cycling,mitophagy,and biogenesis—were disrupted by hyperglycemia in Pgam5^(f/f),but not in Pgam5^(CKO),cardiomyocytes.On the basis of bioinformatics prediction of interaction between PGAM5 and prohibitin 2(PHB2),an inner mitochondrial membrane-associated scaffolding protein,co-immunoprecipitation,and immunoblot assays demonstrated that PGAM5 dephosphorylates PHB2 on Ser91.Transfection of cardiomyocytes with phosphodefective or phosphomimetic Ser91 mutants of PHB2 confirmed a critical role for PGAM5-mediated dephosphorylation of PHB2 in mitochondrial dysfunction associated with hyperglycemic stress.Furthermore,knockin mice expressing phosphomimetic PHB2^(S91D) were resistant to diabetes-induced cardiac dysfunction.Our findings highlight the PGAM-PHB2 axis as a novel and critical regulator of mitochondrial dysfunction in DCM. | Rongjun Zou Jun Tao Jie He Chaojie Wang Songtao Tan Yu Xia Xing Chang Ruibing Li Ge Wang Hao Zhou Xiaoping Fan | 2023 | Research2023，，3： | 0 |
| 18 | 宣威昆明两地肺腺癌患者中生存素表达的比较研究(英文)显示文摘Objective: The aim of our study was to investigate the expression of Survivin in lung adenocarcinoma of Xuanwei and Kunming patients. Methods: Twenty-five specimens of Xuanwei patients and 28 specimens of Kunming patients were observed and analyzed. The Survivin expression was detected by immunohistochemistry. The results were quantitatively analyzed by image analysis system. Results: There were significant differences in Survivin expression (P < 0.01) between Xuanwei patients and Kunming patients. Conclusion: Survivin expression in lung adenocarcinoma of Xuanwei patients was significantly higher than that of Kunming patients. The pathogenesis of lung adenocarcinoma might be different between Xuanwei patients and Kunming patients. High Survivin expression might be one of the reasons to explain high incidence of lung cancer in Xuanwei. | Weiwei Wang Gaofeng Li Zhipeng Hong Shaojia Wang Ruibing Cheng Shoujun Deng Jupeng Zhang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，11： | 0 |
| 19 | Biomimetic Recognition of Organic Drug Molecules in Water by Amide Naphthotubes显示文摘Molecular recognition in water is the basis of numerous biological functions.The key for efficient and selective recognition of an organic drug molecule is to bind both its polar and nonpolar groups.This is achieved by bioreceptors for which specific noncovalent interactions are efficiently used in a hydrophobic pocket.In contrast,most synthetic receptors cannot efficiently bind the neutral,polar groups of drug molecules and,thus,often exhibit poor binding selectivity and affinity.In this research,we report a systematic study on the binding behaviors of three types of macrocyclic hosts(amide naphthotubes,cucurbit[7]uril,andβ-cyclodextrin)to 18 model compounds and 13 drug molecules.Our results show that the high desolvation penalty of polar groups of guests is the reason for the relatively low binding affinity of cucurbit[7]uril andβ-cyclodextrin.However,amide naphthotubes with a biomimetic cavity bind efficiently and selectively to organic guests through hydrophobic effects and hydrogen bonding.Drug molecules with multiple polar groups can be better accommodated by these naphthotubes.The anti-configured naphthotube show good biocompatibility according to preliminary cell experiments and is capable of enhancing the water solubility of two poorly soluble drug molecules.Therefore,they may have practical applications in pharmaceutical sciences. | Yan-Long Ma Mao Quan Xiu-Lian Lin Qian Cheng Huan Yao Xi-Ran Yang Ming-Shuang Li Wei-Er Liu Lin-Ming Bai Ruibing Wang Wei Jiang | 2021 | CCS Chemistry2021，3，4： | 0 |
| 20 | Cucurbit[7]uril as a Broad-Spectrum Antiviral Agent against Diverse RNA Viruses显示文摘The emergence and re-emergence of RNA virus outbreaks highlight the urgent need for the development of broadspectrum antivirals.Polyamines are positively-charged small molecules required for the infectivity of a wide range of RNA viruses,therefore may become good antiviral targets.Cucurbit[7]uril(CB[7]),a synthetic macrocyclic molecule,which can bind with amine-based organic compounds with high affinity,has been shown to regulate bioactive molecules through competitive binding.In this study,we tested the antiviral activity of CB[7]against diverse RNA viruses,including a panel of enteroviruses(i.e.human enterovirus A71,coxsackievirus A16,coxsackievirus B3,and echovirus 11),some flaviviruses(i.e.dengue virus and Zika virus),and an alphavirus representative Semliki forest virus.CB[7]can inhibit virus replications in a variety of cell lines,and its mechanism of action is through the competitive binding with polyamines.Our findings not only for the first time provide evidence that CB[7]can be a promising broad-spectrum antiviral agent,but more importantly,offer a novel therapeutic strategy to fight against RNA viruses by supramolecular sequestration of polyamines. | Jia Quan Xiangjun Zhang Yuanfu Ding Shengke Li Yang Qiu Ruibing Wang Xi Zhou | 2021 | Virologica Sinica2021，36，5： | 0 |
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