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| 1 | pH-Responsive supramolecular DOX-dimer based on cucurbit[8]uril for selective drug release显示文摘A supramolecular dimer of doxorubicin(DOX)was constructed via ternary host-guest interactions between cucurbit[8]uril(CB[8])and tryptophan modified DOX(DOX-Trp,connected with an acid-labile bond)and we demonstrate for the first time that a supramolecular dimer of DOX can be formed upon homo-dimerization by CB[8],which may act as a stimuli pH-responsive,supramolecular DOX dimer prodrug system.This supramolecular DOX dimer transported DOX efficiently and selectively to cancer cells,thereby exhibiting significantly minimized cytotoxicity against noncancerous cells while maintaining effective cytotoxicity against cancer cells.Under this strategy,many other anticancer drugs could be chemically modified and loaded as a dimeric'ammunition'into CB[8]as supramolecular dimer prodrug systems(or a'jet fighter')for improved cancer therapy. | Qian Cheng Shengke Li Yanlong Ma Hang Yin Ruibing Wang | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 2 | Survivin反义寡核苷酸对宣威肺腺癌细胞凋亡的影响(英文)显示文摘Objective:The aim of the study was to investigate the effects of Survivin antioligonucleotide on the proliferation,apoptosis and cell cycle of Xuanwei lung adenocarcinoma cell XWLC-05.Methods:Specific targeting Survivin ASODN was composed firstly.XWLC-05 would be divided into 4 groups:Group Sham(blank),Group Lip(simple liposome),Group Lip-SODN(transfected sense oligonucleotide) and Group Lip-ASODN(transfected ASODN).All groups had been transfected under the same condition for 48 hours.Then West blotting was used to check the expression of Survivin in cells from different groups and flow cytometer was used to find out the apoptosis rate of cells in different groups.Results:The expression of XWLC-05 Survivin in Group Lip-ASODN decreased obviously and apoptosis rate was significantly higher than that of other groups(P < 0.05).Conclusion:XWLC-05 transfected by Survivin ASODN could down regulate the expression of Survivin and lower expression of Survivin might lead to the apoptosis of XWLC-05 and restrain the proliferation of cancer cells. | Weiwei Wang Gaofeng Li Zhipeng Hong Ruibing Cheng Jipeng Zhang Lianhua Ye | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，5： | 1 |
| 3 | Survivin-ASODN靶向治疗XWLC-50细胞移植瘤裸鼠的实验研究(英文)显示文摘Objective:The aim of this study was to study the inhibiting effect of survivin mRNA on transplanted XWLC-05 tumor on nude mice.Methods:We established XWLC-05 transplanted nude mice model.44 mice would be divided randomly into 4 groups:control group (blank),Lip group (simple liposome),survivin SODN group (transfected by sense oligonucleotide) and survivin ASODN group (transfected by antisense oligonucleotide).We would study general activities of nude mice in these 4 groups,measure the size of tumor and calculate the tumor inhabiting rate also.Pathological methods were applied in the analysis of the effect of different treatment on heart,kidney and liver of nude mice in these 4 groups.Results:Tumor grew slowly and size,weight of tumor was lower in survivin ASODN group when compared with that of others.Nude mice of survivin ASODN group showed lower growth index and tumor inhabiting rate was significantly higher than that of other groups (P < 0.05).Transplanted tumor on nude mice in control group (blank),Lip group,and survivin SODN group grew bigger as time passed and there was no significance among them (P > 0.05).We found a great deal of tumor cell necrosis in survivin ASODN group.No death of nude mice was observed in all 4 groups and we did not found obvious lesion in vital organs.Conclusion:Survivin ASDON could be used for the inhibitation of subcutaneously transplanted tumor in nude mice without obvious lesion in vital organs. | Weiwei Wang Shaojia Wang Gaofeng Li Lei Li Ruibing Cheng | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
| 4 | Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly显示文摘Noninvasive in vivo imaging of hepatic glutathione(GSH)levels is essential to early diagnosis and prognosis of acute hepatitis.Although GSH-responsive fluorescence imaging probes have been reported for evaluation of hepatitis conditions,the low penetration depth of light in liver tissue has impeded reliable GSH visualization in the human liver.We present a liver-targeted and GSH-responsive trimodal probe(GdNPs-Gal)for rapid evaluation of lipopolysaccharide-(LPS-)induced acute liver inflammation via noninvasive,real-time in vivo imaging of hepatic GSH depletion.GdNPs-Gal are formed by molecular coassembly of a GSH-responsive Gd(III)-based MRI probe(1-Gd)and a liver-targeted probe(1-Gal)at a mole ratio of 5/1(1-Gd/1-Gal),which shows high r_(1) relaxivity with low fluorescence and fluorine magnetic resonance spectroscopic(^(19)F-MRS)signals.Upon interaction with GSH,1-Gd and 1-Gal are cleaved and GdNPs-Gal rapidly disassemble into small molecules 2-Gd,2-Gal,and 3,producing a substantial decline in r_(1) relaxivity with compensatory enhancements in fluorescence and ^(19)F-MRS.By combining in vivo magnetic resonance imaging(^(1)H-MRI)with ex vivo fluorescence imaging and ^(19)F-MRS analysis,GdNPs-Gal efficiently detect hepatic GSH using three independent modalities.We noninvasively visualized LPS-induced liver inflammation and longitudinally monitored its remediation in mice after treatment with an anti-inflammatory drug,dexamethasone(DEX).Findings highlight the potential of GdNPs-Gal for in vivo imaging of liver inflammation by integrating molecular coassembly with GSH-driven disassembly,which can be applied to other responsive molecular probes for improved in vivo imaging. | Yuxuan Hu Yuqi Wang Xidan Wen Yifan Pan Xiaoyang Cheng Ruibing An Guandao Gao Hong-Yuan Chen Deju Ye | 2020 | Research2020，，1： | 0 |
| 5 | 宣威昆明两地肺腺癌患者中生存素表达的比较研究(英文)显示文摘Objective: The aim of our study was to investigate the expression of Survivin in lung adenocarcinoma of Xuanwei and Kunming patients. Methods: Twenty-five specimens of Xuanwei patients and 28 specimens of Kunming patients were observed and analyzed. The Survivin expression was detected by immunohistochemistry. The results were quantitatively analyzed by image analysis system. Results: There were significant differences in Survivin expression (P < 0.01) between Xuanwei patients and Kunming patients. Conclusion: Survivin expression in lung adenocarcinoma of Xuanwei patients was significantly higher than that of Kunming patients. The pathogenesis of lung adenocarcinoma might be different between Xuanwei patients and Kunming patients. High Survivin expression might be one of the reasons to explain high incidence of lung cancer in Xuanwei. | Weiwei Wang Gaofeng Li Zhipeng Hong Shaojia Wang Ruibing Cheng Shoujun Deng Jupeng Zhang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，11： | 0 |
| 6 | Biomimetic Recognition of Organic Drug Molecules in Water by Amide Naphthotubes显示文摘Molecular recognition in water is the basis of numerous biological functions.The key for efficient and selective recognition of an organic drug molecule is to bind both its polar and nonpolar groups.This is achieved by bioreceptors for which specific noncovalent interactions are efficiently used in a hydrophobic pocket.In contrast,most synthetic receptors cannot efficiently bind the neutral,polar groups of drug molecules and,thus,often exhibit poor binding selectivity and affinity.In this research,we report a systematic study on the binding behaviors of three types of macrocyclic hosts(amide naphthotubes,cucurbit[7]uril,andβ-cyclodextrin)to 18 model compounds and 13 drug molecules.Our results show that the high desolvation penalty of polar groups of guests is the reason for the relatively low binding affinity of cucurbit[7]uril andβ-cyclodextrin.However,amide naphthotubes with a biomimetic cavity bind efficiently and selectively to organic guests through hydrophobic effects and hydrogen bonding.Drug molecules with multiple polar groups can be better accommodated by these naphthotubes.The anti-configured naphthotube show good biocompatibility according to preliminary cell experiments and is capable of enhancing the water solubility of two poorly soluble drug molecules.Therefore,they may have practical applications in pharmaceutical sciences. | Yan-Long Ma Mao Quan Xiu-Lian Lin Qian Cheng Huan Yao Xi-Ran Yang Ming-Shuang Li Wei-Er Liu Lin-Ming Bai Ruibing Wang Wei Jiang | 2021 | CCS Chemistry2021，3，4： | 0 |
| 7 | Biomimetic Recognition-Based Bioorthogonal Host-Guest Pairs for Cell Targeting and Tissue Imaging in Living Animals显示文摘Bioconjugation methods offer very important tools in studying biological systems.Synthetic host-guest pairs provide an alternative and complementary conjugation method to bioorthogonal reactions and biological association pairs.Nevertheless,macrocyclic hosts that can be used for in situ capture are limited and often rely on extremely high binding affinities.Herein,we report an alternative bioorthogonal host-guest pair that relies on highly selective molecular recognition in water.The host,namely amide naphthotube,possesses a biomimetic cavity with inward-directing hydrogen bonding sites and shows selective and strong binding to the guest(2-phenyl pyrimidine)even in biological media.Through anchoring the tetraphenyl ethylene-modi fied hosts to cell surfaces,the bioorthogonal host-guest pair can be applied in cell surface recognition,cell-cell interactions,and tissue imaging in mice.The bioorthogonality is originated from the high binding selectivity of the biomimetic macrocyclic host,which is different from other known host-guest pairs that have been applied in biological systems.This research provides a new noncovalent bioconjugation tool and a new concept for designing bioorthogonal host-guest pairs for biological applications. | Yan-Long Ma Chen Sun Zeshun Li Ziyi Wang Jianwen Wei Qian Cheng Li-Shuo Zheng Xiao-Yong Chang Kai Li Ruibing Wang Wei Jiang | 2022 | CCS Chemistry2022，4，6： | 0 |
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