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| 1 | In vivo imaging of endogenous neural stem cells in the adult brain显示文摘The discovery of endogenous neural stem cells(e NSCs) in the adult mammalian brain with their ability to self-renew and differentiate into functional neurons, astrocytes and oligodendrocytes has raised the hope for novel therapies of neurological diseases. Experimentally, those e NSCs can be mobilized in vivo, enhancing regeneration and accelerating functional recovery after, e.g., focal cerebral ischemia, thus constituting a most promising approach in stem cell research. In order to translate those current experimental approaches into a clinical setting in the future, non-invasive imaging methods are required to monitor e NSC activation in a longitudinal and intraindividual manner. As yet, imaging protocols to assess eNSC mobilization non-invasively in the live brain remain scarce, but considerable progress has been made in this field in recent years. This review summarizes and discusses the current imaging modalities suitable to monitor e NSCs in individual experimental animals over time, including optical imaging, magnetic resonance tomography and-spectroscopy, as well as positron emission tomography(PET). Special emphasis is put on the potential of each imaging method for a possible clinical translation, and on the specificity of the signal obtained. PET-imaging with the radiotracer 3'-deoxy-3'-[18F]fluoro-L-thymidine in particular constitutes a modality with excellent potential for clinical translation but low specificity; however, concomitant imaging of neuroinflammation is feasible and increases its specificity. The non-invasive imaging strategies presented here allow for the exploitation of novel treatment strategies based upon the regenerative potential of e NSCs, and will help to facilitate a translation into the clinical setting. | Maria Adele Rueger Michael Schroeter | 2015 | World Journal of Stem Cells2015，7，1： | 3 |
| 2 | The Treatment of Intertrochanteric Fractures: Results Using an Intramedullary Nail With Integrated Cephalocervical Screws and Linear Compression显示文摘 | Andreas H Ruecker M Rupprecht M Gruber M Gebauer F Barvencik D Briem J M Rueger | 2009 | Journal of Orthopaedic Trauma2009，，1： | 2 |
| 3 | New derivatives of 5,10-dihydro- 11H-dibenzo diazepine- 11-ones with anticholinergic activity 显示文摘 | Rueger C Rohnert H Lohmann D | 1990 | Pharmazie1990，45，8： | 1 |
| 4 | Distal fracture of the hu- merus显示文摘 | Rueger JM Rticker A Briem D | 2007 | Chirurg2007，，： | 1 |
| 5 | Isolated sphenoid sinus disease显示文摘 | Rothfield RE deVries EJ Rueger RG | | 0，，： | 1 |
| 6 | Targeting neural precursors in the adult brain rescues injured dopamine neurons显示文摘 | Androutsellis-Theotokis A Rueger MA Park DM | 2009 | Proc Natl Acad Sci USA2009，106，13： | 1 |
| 7 | Osteogenic protein-1, biology andapplications显示文摘 | Cook SD Rueger DC | 1996 | Clin Orthop1996，324，： | 1 |
| 8 | OP-1 eDNA encodes an osteogenic protein in the TGF-beta family 显示文摘 | Ozkaynak E Rueger DC Drier EA | 1990 | EMBO J1990，9，7： | 1 |
| 9 | The superior laryngeal nerve and the interarytenoid muscle in humans: an anatomical study 显示文摘 | Rueger R S | 1972 | Laryngoscope1972，82，11： | 1 |
| 10 | Signa- ling pathways controlling neural stem cells slow progressive brain disease 显示文摘 | Androutsellis TA Rueger MA Mkhikian H | 2008 | Cold Spring Harb Symp Quant Biol2008，73，： | 1 |
| 11 | Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1:A preliminary study显示文摘 | Terheyden H Jepsen S Rueger DR | 1999 | Int J Oral Maxillofac Surg1999，28，6： | 1 |
| 12 | OP-I cDNA encodes an osteogenic protein in the TGF-heta family 显示文摘 | Ozkaynak E Rueger DC Drier EA | 1990 | EMBO J1990，9，7： | 1 |
| 13 | Proximal Humeral Frac- tures: Nailing显示文摘 | Rueger JM Rticker A Briem D | 2007 | Eur J Trauma Emerg Surg2007，33，： | 1 |
| 14 | Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1 : a preliminary study 显示文摘 | Terheyden H Jepsen S Rueger DR | 1999 | Int J Oral Maxillofac Surg1999，28，6： | 1 |
| 15 | Multislice CT(MSCT)in the detection and classification of pelvic and acetabular fractures显示文摘 | Wedeg rtner U Gatzka C Rueger JM | 2003 | Rofo2003，175，1： | 1 |
| 16 | The impact of psoriasis on quality of life:results of a 1998 National Psoriasis Foundation patient-member-ship survey显示文摘 | rueger G Koo J Lebwohl M | 2001 | Arch Dermatol2001，137，3： | 1 |
| 17 | Induction of ce- mentogenesis by recombinant human osteogenic protein-1 (hop- 1/bmp-7) in the baboon ( Papio ursinus) 显示文摘 | Ripamonti U Heliotis M Rueger DC | 1996 | Arch Oral Biol1996，41，1： | 1 |
| 18 | Induction of bone formation by recombinant human osteogenic protein-1 and sintered porous bydroxyapatite in adult primates 显示文摘 | Ripamonti U Crook J Rueger DC | 2001 | Plast Reconstr Surg2001，107，4： | 1 |
| 19 | Relationship between mul- tiple sources of perceived social support and psychological and aca- demic adjustment in early adolescence: comparisons across gender 显示文摘 | Rueger SY Malecki CK Demaray MK | 2010 | J Youth Adolesc2010，39，1： | 1 |
| 20 | Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes显示文摘 | Bruehl H Rueger M Dziobek I | 2007 | J Clin Endocrinol Metab2007，92，7： | 1 |
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