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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | Complications of diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | E Masci G Toti A Mariani S Curioni A Lomazzi M Dinelli G Minoli C Crosta U Comin A Fertitta A Prada G Rubis Passoni P.A Testoni | 2001 | The American Journal of Gastroenterology2001，，2： | 4 |
| 3 | Review of in situ remediation technologies for lead, zinc, and cadmium in soil显示文摘 | Martin T A Ruby M V | 2004 | Remediation Journal2004，4，3： | 1 |
| 4 | Studies on CYP1A1,CYP1B1 and CYP3A4 gene polymorphisms in breast cancer patients显示文摘 | Ociepa-Zawal M Rubis B Filas V | 2009 | Ginekol Pol2009，80，11： | 1 |
| 5 | Optimal management of metastaticmelanoma: current strategies and future directions显示文摘 | Batus M Waheed S Ruby C | 2013 | Am J ClinDermatol2013，14，3： | 1 |
| 6 | Stress and the effects of airtransport on flight crews显示文摘 | Brenda JH Ruby M | 2001 | Air ned J2001，20，6： | 1 |
| 7 | Noninvasive ventilatory support does not facilitate recovery from acute respiratory failure in chronic obstructive pulmonary disease 显示文摘 | Barbe F Togores B Rubi M | 1996 | Eur Respir J1996，9，6： | 1 |
| 8 | Advances in e- valuating the oral bioavailability of inorganics in soil for use in human health risk assessment 显示文摘 | Ruby M V Schoof R Brattin W | 1999 | Environ- mental Science & Technology1999，33，21： | 1 |
| 9 | In sire formation of lead phosphates in soils as a method to immobilize lead显示文摘 | Ruby M V Davis A Nicholson A | 1994 | Environ Sci Technol1994，28，： | 1 |
| 10 | Enhanced ENA-78 and IL-8expression in patients with malignant pancreatic diseases显示文摘 | Frick VO Rubie C Wagner M | | 0，，： | 1 |
| 11 | Pars plana vitrectomy with removal of the internal limiting membrane in the treatment of persistent diabetic macular edema显示文摘 | Recchia F M Ruby A J Carvalho Recchia C A | 2005 | Am J Ophthalmol2005，139，： | 1 |
| 12 | Enhanced ENA-78 and IL-8 ex- pression in patients with malignant pancreatic diseases显示文摘 | Frick VO Rubie C Wagner M | 2008 | Pancreatol- ogy2008，8，45： | 1 |
| 13 | Complications of diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | E Masci G Toti A Mariani S Curioni A Lomazzi M Dinelli G Minoli C Crosta U Comin A Fertitta A Prada G Rubis Passoni P.A Testoni | 2001 | The American Journal of Gastroenterology2001，，2： | 1 |
| 14 | Human telomerase activity regulation显示文摘 | Wojtyla A Gladych M Rubis B | 2011 | Mol Biol Rep2011，38，5： | 1 |
| 15 | Epidemiol- ogy of medication-related adverse events in nursing homes 显示文摘 | HANDLER S M WRIGHT R M RUBY C M | 2006 | Am J C eriatr Pharmacother2006，4，3： | 1 |
| 16 | Noise suppression by noise 显示文摘 | J M G Vilar J M Rubi | 2001 | Physical Review Letters2001，86，6： | 1 |
| 17 | Direct PCR Analysis for Toxigenic Pasteurella multocida 显示文摘 | Carol A Lichtensteiger Susan M Steenbergen Ruby M Lee | 1996 | Journal of Clinical Microgiology1996，32，12： | 1 |
| 18 | Advances in evaluation the oral bioavailability using a physiological based extraction test显示文摘 | | 1999 | Environmental Science and Technology1999，33，： | 1 |
| 19 | Review of in situ remediation technologies for lead, zinc, and cadmium in soil显示文摘 | Martin T A Ruby M V | 2004 | Rcmediation Journal2004，14，3： | 1 |
| 20 | Chemoenzymatic syntheses of polyamines and teraazamacrocycles显示文摘 | Rubi M Astorga C Gotor V | 2002 | Synth Commun2002，32，： | 1 |
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