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| 1 | Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drugresistant sublines显示文摘AIM: To investigate the expression and function of classicalprotein kinase C (PKC) isoenzymes in inducing MDRphenotype in gastric cancer cells.METHODS: Two cell lines were used in the study: gastriccancer cell SGC7901 and its drug-resistant cell SGC7901/VCRstepwise-selected by vincristine 0.3, 0. 7 and 1.0 mg@ L-1 ,respectively. The expression of classical PKC (cPKC)isoenzymes in SGC7901 cells and SGC7901/VCR cells weredetected using immunofluorescent cytochemistry, laserconfocal scanning microscope and Wsstern blot. The effectsof anti-PKC isoenzymes antibody of adriamycinaccumulation in SGC7901/VCR cells were determined usingflow cytometric analysis.RESULTS: (1) SGC7901 cells exhibited positive staining ofPKC-α. SGC7901/VCR cells exhibited stronger staining ofPKC-α than SGC7901 cells. The higher dosage vincristineselected, the much stronger staining of PKC-α was observedon SGC7901/VCR cells. (2) Both SGC7901 and SGC7901/VCRcells exhibited positive staining of PKC-βⅠ and PKC-βⅡ withno significant difference. ( 3 ) Compared with SGC7901,SGC7901/VCR cells had decreased adriamycin accumulationand retention. Accumulation of adriamycin in SGC7901 was5.21 + 2.56 mg@ L-1, in SGC7901/VCR 0.3 was 0.85 + 0.29 mg@L-1 , in SGC7901/VCR 0.7 was 0.81 + 0.32 og@ L-1 , and inSGC7901NCR 1.0 was 0.80 + 0.33 mg @ L-1; Retention ofadriamycin in SGC 7901 was 2.51 + 1.23 mg@L-1, in SGC7901/VCR 0.3 was 0.47 + 0.14 mg@ L-1 , in SGC7901/VCR 0.7 was 0.44 + 0.15 mg@ L-1, and in SGC 7901/VCR 1.0 was 0.41 + 0.1 1mg @ L-1 . (4) Fluorescence intensity presented adriamycinaccumulation in SGC7901/VCR cells was increased from 1.14+0.36 to 2.71 +0.94 when cells were co-incubated with anti-PKC-αbut not with anti-PKC-βⅠ, PKC-βⅡ and PKCγ antibodies.CONCLUSION: PKC-α, but not PKC-βⅠ, PKC-βⅡ or PKCγ,may play a role in multidrug resistance of gastric cancercells SGC7901/VCR. | Ying Han Zhe-Yi Han Xin-Min Zhou Ru Shi Yue Zheng Yong-Quan Shi Ji-Yan Miao Bo-Rong Pan Dai-Ming Fan | 2002 | World Journal of Gastroenterology2002，8，3： | 25 |
| 2 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 3 | Protective effects of a novel drug RC28-E blocking both VEGF and FGF2 on early diabetic rat retina显示文摘AIM: To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats.METHODS: The streptozotocin(STZ)-induced diabetic rats were randomly divided into 6 groups: diabetes mellitus(DM) group(saline, 3 μL/eye); RC28-E at low(0.33 μg/μL, 3 μL), medium(1 μg/μL, 3 μL), and high(3 μg/μL,3 μL) dose groups; vascular endothelial growth factor(VEGF) Trap group(1 μg/μL, 3 μL); fibroblast growth factor(FGF) Trap group(1 μg/μL, 3 μL). Normal control group was included. At week 1 and 4 following diabetic induction,the rats were intravitreally injected with the corresponding solutions. At week 6 following the induction, apoptosis in retinal vessels was detected by TUNEL staining.Glial fibrillary acidic protein(GFAP) expression was examined by immunofluorescence. Blood-retinal barrier(BRB) breakdown was assessed by Evans blue assay.Ultrastructural changes in choroidal and retinal vessels were analyzed by transmission electron microscopy(TEM).Content of VEGF and FGF proteins in retina was measured by enzyme linked immunosorbent assay(ELISA). The retinal expression of intercellular cell adhesion molecule-1(ICAM-1), tumor necrosis factor-α(TNF-α), VEGF and FGF genes was examined by quantitative polymerase chain reaction(qPCR).RESULTS: TUNEL staining showed that the aberrantly increased apoptotic cells death in diabetic retinal vascular network was significantly reduced by treatments of medium and high dose RC28-E, VEGF Trap, and FGF Trap(all P<0.05), the effects of medium and high dose RC28-E or FGF Trap were greater than VEGF Trap(P<0.01). GFAP staining suggested that reactive gliosis was substantially inhibited in all RC28-E and VEGF Trap groups, but the inhibition in FGF Trap group was not as prominent.Evans blue assay demonstrated that only high dose RC28-E could significantly reduce vascular leakage in early diabetic retina(P<0.01). TEM revealed that the ultrastructures in choroidal and retinal vessels were damaged in early diabetic retina, which was ameliorated to differential extents by each drug. The expression of VEGF and FGF2 proteins was significantly upregulated in early diabetic retina, and normalized by RC28-E at all dosages and by the corresponding Traps. The upregulation of ICAM-1 and TNF-α in diabetic retina was substantially suppressed by RC28-E and positive control drugs.CONCLUSION: Dual blockade of VEGF and FGF2 by RC28-E generates remarkable protective effects, including anti-apoptosis, anti-gliosis, anti-leakage, and improving ultrastructures and proinflammatory microenvironment,in early diabetic retina, thereby supporting further development of RC28-E into a novel and effective drug to diabetic retinopathy(DR). | Qian-Hui Yang Yan Zhang Jing Jiang Mian-Mian Wu Qian Han Qi-Yu Bo Guang-Wei Yu Yu-Sha Ru Xun Liu Min Huang Ling Wang Xiao-Min Zhang Jian-Min Fang Xiao-Rong Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 9 |
| 4 | Altered Resting-State Signals in Patients with Acute Stroke In or Under the Thalamus显示文摘Previous studies have suggested that cortical functional reorganization is associated with motor recovery after stroke and that normal afferent sensory information is very important in that process.In this study,we selected patients who had a stroke in or under the thalamus,with potentially impaired afferent sensory information and analyzed the differences between these patients and healthy controls at three levels:brain regions,the functional connectivity between brain areas,and the whole-brain functional network.Compared with healthy controls,regional homogeneities in the left middle temporal gyrus decreased and functional connectivity between the left middle temporal gyrus and the stroke area increased in the patients.However,there was no significant change in the wholebrain functional network.By focusing on stroke located in or under the thalamus,our study contributes to wider inquiries into understanding and treating stroke. | Lijun Chen Chuanfu Li Jian Zhai Anqin Wang Qin Song Ying Liu Ru Ma Long Han Yamikani Ndasaukas Xiaoming Li Hai Li Xiaochu Zhang | 2016 | Neuroscience Bulletin2016，32，6： | 6 |
| 5 | In Situ HRTEM Observation of Electron-Irradiation-Induced Amorphization and Dissolution of the E(Al_(18)Cr_2Mg_3) Phase in 7475 Al Alloy显示文摘Electron irradiation effects on phase stability of the E(Al18Cr2Mg3) phase have been investigated by highangle annular dark-field scanning transmission electron microscopy and high-resolution transmission electron microscopy(HRTEM). The in situ HRTEM observations show that the Al18Cr2Mg3 particles with different thickness undergo amorphization and dissolution under 300 ke V electron irradiation at 25 °C. The results indicate that the intermetallic compound Al18Cr2Mg3 is unstable under electron irradiation, and structural changes mainly depend on the thickness of particles. Amorphization in the thick particles is caused by a combination of chemical disordering and an increase in point defect concentration. Dissolution after amorphization in the thin particles is attributed to the diffusion of point defect towards the Al matrix. | Mao-Hua Li Yan-Qing Yang Bin Huang Xian Luo Wei Zhang Yan-Xia Chen Ming Han Ji-Gang Ru | 2015 | Acta Metallurgica Sinica(English Letters)2015，28，2： | 5 |
| 6 | Prevalence and Risk Factors Associated with Adverse Drug Reactions among Previously Treated Tuberculosis Patients in China显示文摘我们与 anti-TB 药估计了不利的药反应(ADR ) 的发生并且为在中国在以前对待的肺结核病人开发 ADR 评估了风险因素。所有病人是由国家指南推荐了收到了首要的 anti-TB 政体(2HREZS/6HRE ) 。临床并且实验室评估一个月被执行一次。从 354 个参加者,(74.0%) 262 经历了象 hyperuricemia 那样的 ADR (65.0% , 230/354 ) , hepatotoxicity (6.2% , 22/354 ) 并且听觉骚乱(4.8% , 17/354 ) 。ADR 显著地与糖尿病 mellitus 被联系[或(95% CI ) :15.5 (2.07-115.87 )] ;然而,重量超过 50 kg [或(95% CI ) :0.41 (0.22-0.85 )] 是为 ADR 的出现的一个保护的因素。Hyperuricemia 是最普通的不利事件但是,有 hyperuricemia 的大多数病人为高尿的酸层次显示出增加的忍耐。低身体重量和糖尿病 mellitus 在 anti-TB 治疗期间增加了 ADR 的出现的风险。 | HAN Xi Qin PANG Yu MA Yan LIU Yu Hong GUO Ru SHU Wei HUANG Xue Rui GE Qi Ping DU Jian GAO Wei Wei | 2017 | Biomedical and Environmental Sciences2017，30，2： | 5 |
| 7 | Effects of octreotide on gallbladder pressure and myoelectric activity of Oddi sphincter in rabbits显示文摘EfectsofoctreotideongalbladderpressureandmyoelectricactivityofOddisphincterinrabbitsZHOUJianHua,LIUChuanYong,ZHANGRuHua,W... | ZHOU Jian Hua, LIU Chuan Yong, ZHANG Ru Hua, WANG Han Ru and LIU Ke Jing | 1998 | World Journal of Gastroenterology1998，4，3： | 5 |
| 8 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Cervical Cancer—China,2003–2017显示文摘Introduction:This study reported the trends and analyzed the age-period-cohort effects on the incidence and mortality rates of cervical cancer in China.Methods:The age-standardized incidence rate(ASIR)and mortality rate(ASMR)by Segi’s world standard population were calculated using qualified consecutive data from 22 cancer registries from 2003 to 2017 in China.We performed joinpoint analysis to describe the trends and age-period-cohort analysis to estimate the independent effects of age,period and cohort on trends in incidence and mortality rates of cervical cancer.Results:The ASIR and ASMR for cervical cancer in females over 20 years old increased during 2003−2017.For females<50 years,a decreasing trend in ASIR and a stable trend in ASMR were observed in urban areas after 2009.But the ASIR and ASMR kept increasing in rural areas during the whole period.For females>50 years,the ASIR and ASMR increased both in urban and rural areas.Age-period-cohort analysis showed increasing period effects on cervical cancer incidence and mortality during the whole period.The cohort effects exhibited a downward-upwarddownward pattern for the incidence(1918–1938,1938–1963,1963–1993)and mortality rates(1918–1943,1943–1963,1963–1993)in urban areas,a fluctuating pattern for incidence rate and a continuing downward pattern for mortality rate(1918–1993)in rural areas.Conclusions:The increases in cervical cancer incidence and mortality rates can be mostly explained by period effects.We observed decreases in risk for cervical cancer incidence and mortality in young female generations,which were more obvious in urban areas. | Kexin Sun Rongshou Zheng Lin Lei Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2022 | China CDC weekly2022，4，48： | 4 |
| 9 | EQR SiPM with P-on-N diode configuration显示文摘The silicon photomultiplier(SiPM) with epitaxial quenching resistor(EQR) is an emerging and developing technology that has recently attracted the interest from the research community. It has characteristics of a continuous low-resistance cap layer and integrated quenching resisters in epitaxial silicon layer, which makes it possible to increase microcell density or reduce microcell size, thus obtaining large dynamic range and high photon detection efficiency(PDE) simultaneously. Results published show that the EQR SiPM with N-on-P diode configuration had relatively low PDE at peak wavelength of 480 nm as 16%. This paper reported the EQR SiPM with P-on-N diode configuration having active area of 3 × 3 mm^2 and cell density of 10,000/mm^2(total 90,000 pixels). It was characterized with gain of 2E5, dark count rate of 7 MHz, crosstalk of 7%, dynamic range of 85,000 pixels, overall recovery time of 32 ns at room temperature and over-voltage of 3.5 V. The improved PDE at peak wavelength of 420 nm was 30%. | Jian-Quan Jia Jia-Li Jiang Kun Liang Ru Yang De-Jun Han | 2019 | Nuclear Science and Techniques2019，30，8： | 2 |
| 10 | Development of a low-background neutron detector array显示文摘A low-background neutron detector array was developed to measure the cross section of the ^(13)C(a,n)^(16)O reaction,which is the neutron source for the s-process in AGB stars,in the Gamow window(E_(c.m.)=190±40 keV)at the China Jinping Underground Laboratory(CJPL).The detector array consists of 24^(3)He proportional counters embedded in a polyethylene cube.Owing to the deep underground location and a borated polyethylene shield around the detector array,a low background of 4.5(2)/h was achieved.The ^(51)V(p,n)^(51)Cr reaction was used to determine the neutron detection efficiency of the array for neutrons with energies E_(n)<1 MeV.Geant4 simulations are shown to effectively reproduce the experimental results.They were used to extrapolate the detection efficiency to higher energies for neutrons emitted in the ^(13)C(α,n)^(16)O reaction.The theoretical angular distributions of the ^(13)C(α,n)^(16)O reaction were shown to be important in the estimation of the uncertainties of the detection efficiency. | Yu-Tian Li Wei-Ping Lin Bing-Shui Gao Han Chen Hao Huang Yu Huang Tao-Yu Jiao Kuo-Ang Li Xiao-Dong Tang Xin-Yu Wang Xiao Fang Han-Xiong Huang Jie Ren Long-Hui Ru Xi-Chao Ruan Ning-Tao Zhang Zhi-Chao Zhang | 2022 | Nuclear Science and Techniques2022，33，4： | 2 |
| 11 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 12 | Association between Phthalate Exposure and the Use of Plastic Containers in Shanghai Adults显示文摘Objective Consuming phthalates may be due to the presence of food contact materials,such as plastic containers.In this study,we investigated the association between plastic container use and phthalate exposure in 2,140 Shanghai adults.Methods Participants completed a questionnaire on the frequency of using plastic containers in different scenarios in the previous year(e.g.,daily,weekly) and on the consumption of plastic-packaged foods in the previous three days(yes or no).Urinary phthalate metabolites were used to assess the association between phthalate exposure and the use of plastic containers.Results The metabolites of di-(2-ethylhexyl) phthalate(DEHP) were the most frequently detected in urine.The results revealed that phthalate exposure was associated with consumption of plastic-packaged breakfast or processed food items in the previous three days.The consumption of these two food items had strong synergistic effects on increasing urinary concentrations of most phthalate metabolites.Conclusion Our results of plastic-packaged breakfast and processed food may be explained by the use of flexible plastic containers,indicating the importance of risk assessment for the application of flexible plastic containers. | DONG Rui Hua ZHANG Han ZHANG Mei Ru CHEN Jing Si WU Min LI Shu Guang CHEN Bo | 2017 | Biomedical and Environmental Sciences2017，30，10： | 2 |
| 13 | Effect of Pd doping on the acetone-sensing properties of NdFeO_3显示文摘The acetone-sensing properties of the undoped and Pd doped perovskite-type oxides NdFeO3 were investigated from room temperature to 400°C. The perovskite-type NdFeO3 was synthesized by a sol-gel method, and the dopants Pd with the content from 1wt% to 5wt% were implanted into NdFeO3 nanoparticles by thermal diffusion. X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques show that NdFeO3 is an orthorhombic structure with the average particle size of about 40 nm. A giant acetone-sensing response of 675.7 is observed when the Pd content in NdFeO3 powders is about 3wt%. The response and recovery time of the sensor to the 5×10-4 acetone gas are 16 and 1 s, respectively. At the same time, it performs a good selectivity to acetone gas and may be a new promising material candidate for the acetone-sensor development. | Zhan-lei Wu Ru Zhang Ma Zhao Shao-ming Fang Zhou-xiang Han Ji-fan Hu Kai-ying Wang | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，2： | 1 |
| 14 | Trans - specific nematicidal activity of Photorhabdus luminescens 显示文摘 | Han RC Ehlers RU | 1999 | Nematology1999，1，： | 1 |
| 15 | Effect of Photorhabdus luminescens phase variants on the in vivo and in vitro development and reproduction of the entomopathogenic nematodes Heterorhabditis bacteriophora and Steinernema carpocapsae 显示文摘 | Han RC Ehlers RU | 2001 | FEMS Microbiology Ecology2001，35，21： | 1 |
| 16 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Female Breast Cancer—China,2003-2017显示文摘Introduction:This study reported the trends in female breast cancer incidence and mortality rates in China,and analyzed the corresponding age-periodcohort effects.Methods:Data from 22 population-based cancer registries in China between 2003 and 2017 were analyzed.Age-standardized incidence rates(ASIR)and mortality rates(ASMR)were calculated using Segi’s world standard population.Joinpoint regression was employed to evaluate trends,and age-period-cohort effects were examined using the intrinsic estimator method.Results:The ASIR for female breast cancer exhibited a more rapid increase in rural areas compared to urban areas across all age groups.The most substantial increase was observed in the 20-34 age group in rural areas[annual percent change(APC)=9.0%,95%confidence interval(CI):7.0%-11.0%,P<0.001].The ASMR for females under 50 years old remained stable from 2003 to 2017 in both urban and rural areas.However,the ASMR for females over 50 in rural areas and those over 65 in urban areas demonstrated a significant increase,with the most pronounced increase observed among females over 65 in rural areas(APC=4.9%,95%CI:2.8%-7.0%,P<0.001).Age-period-cohort analysis revealed increasing period effects and decreasing cohort effects for female breast cancer incidence and mortality rates in both urban and rural settings.Notably,the cohort effect for incidence displayed a slight upward trend for females born between 1983 and 1992 in rural areas.Conclusions:Our study revealed a rapid increase in breast cancer incidence among younger generations and an accelerated mortality rate in older populations residing in rural areas.To effectively address the growing burden of female breast cancer in China,it is essential to develop and implement targeted intervention strategies. | Kexin Sun Lin Lei Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2023 | China CDC weekly2023，5，15： | 1 |
| 17 | Low-loading gold in situ doped with sulfur by biomolecule-assisted approach for promoted electrochemical carbon dioxide reduction显示文摘For electrochemical carbon dioxide reduction(CO_(2)RR),CO_(2)-to-CO conversion is considered an ideal route towards carbon neutrality for practical applications.Gold(Au)is known as a promising catalyst with high selectivity for CO;however,it suffers from high cost and low mass-specific activity.In this study,we design and prepare a catalyst featuring uniform S-doped Au nanoparticles on N-doped carbon support(denoted as S-Au/NC)by an in situ synthesis strategy using biomolecules.The S-Au/NC displays high activity and selectivity for CO in CO_(2)RR with a Au loading as low as 0.4 wt.%.The Faradaic efficiency of CO(FECO)for S-Au/NC is above 95%at−0.75 V(vs.RHE);by contrast,the FECO of Au/NC(without S)is only 58%.The Tafel slope is 77.4 mV·dec−1,revealing a favorable kinetics process.Furthermore,S-Au/NC exhibits an excellent long-term stability for CO_(2)RR.Density functional theory(DFT)calculations reveal that the S dopant can boost the activity by reducing the free energy change of the potential-limiting step(formation of the*COOH intermediate).This work not only demonstrates a model catalyst featuring significantly reduced use of noble metals,but also establishes an in situ synthesis strategy for preparing high-performance catalysts. | Meijie Tan Xiaoqian Han Sen Ru Chao Zhang Zhouru Ji Zhaolin Shi Guomeng Qiao Yunying Wang Ruixue Cui Qiquan Luo Jiqing Jiao Yaguang Li Tongbu Lu | 2023 | Nano Research2023，16，2： | 1 |
| 18 | Complex toxic effects of Cd2 +, Zn2 +, and acid rain on growth of kidney bean ( Phaseolus vulgaris L) 显示文摘 | Bo -han Liao Hong - yu Liu Qing - ru Zeng Ping - zhong Yu Anne Probst Jean - Luc Probst | 2005 | Environment International2005，31，： | 1 |
| 19 | Precipitation process along dislocations in A1-Cu-Mg alloy during artificial aging 显示文摘 | FENG Z Q YANG Y Q HUANG B HAN M LUO X RU J G | 2010 | Materials Science and Engineering A2010，528，2： | 1 |
| 20 | Impacts of land cover change on plant and bird species diversity in Hainan Island,China显示文摘1IntroductionLandcoverchangehasanincreasingimpactonforestecosystemsworldwide.Thedestructionofnativehabitatsisrecognizedasoneo... | Ouyang Zhi yun, Wang Ru song, Wang Xiao ke, Xiao Han Research Center for Eco Environmental Sciences,Chinese Academy of Sciences,Beijing 100085, China | 1999 | Journal of Environmental Sciences1999，11，2： | 1 |
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