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| 1 | LITHOSPHERE-ASTHENOSPHERE INTERACTION: A COMPARATIVE STUDY ON CENOZOIC AND MESOZOIC BASALTS AROUND BOHAI AREA | Yigang Xu Weiming Fan and Ge Lin( Guangzhou Institute of Geochemistry , Chinese Academy of Sciences , Guangzhou , P. R, China)(Department of Gedegy, Royal Holoway Univoersity of London, Egham, Surrey, TW20OEX , UK)(Changsha Institute of Geotectonics,Chin | 1995 | Geotectonica et Metallogenia1995，19，4： | 16 |
| 2 | Revisiting the origin of modern humans in China and its implications for global human evolution显示文摘The debates over the origin of modern humans have long been centered on two competing theories:the 'Out-of-Africa'(single-place origin) theory and the 'Multi-regional Evolution' theory.China is an extremely important region where many ancient human fossils were collected along with numerous associated faunal remains and artefacts.These cultural remains,unearthed from different areas in the country and covering a long time span,will help clarify the controversy.The study of cultural materials in China is expected to shed important light on biological evolutionary patterns and social and technical developments of those early humans as well as their environmental conditions.Based on the analysis of Chinese fossils and associated materials,in conjunction with some genetic studies,this paper aims at evaluating each of the two theories in order to stimulate more discussions.Our study suggests that the evolutionary model of 'Continuity with Hybridization' is most relevant in reflecting the current understanding of human evolutionary history in China.Furthermore,we propose that the concept of regional diversity of evolutionary models should be seriously considered to illustrate different evolutionary modes applied to different parts of the world. | GAO Xing1,2*,ZHANG XiaoLing1,2,3,YANG DongYa2,4,SHEN Chen2,5 & WU XinZhi1,2 1 Institute of Vertebrate Paleontology and Paleoanthropology,Chinese Academy of Sciences,Beijing 100044,China 2 Laboratory of Human Evolution,Chinese Academy of Sciences,Beijing 100044,China 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 4 Department of Archaeology,Simon Fraser University,Vancouver V5A 1S6,Canada 5 The Royal Ontario Museum,Toronto M5S 2C6,Canada | 2010 | Science China Earth Sciences2010，53，12： | 11 |
| 3 | Use-wear analysis confirms the use of Palaeolithic bone tools by the Lingjing Xuchang early human显示文摘During 2007-2008 excavations at the Lingjing site near Xuchang,Henan Province,dated back to around 100-80 ka ago,a large quantity of mammalian fossil remains were recovered along with a remarkable cluster of Early Modern Human(EMH) skull fragments in situ.Observably some of those animal bones were probably modified into tools.A use-wear analysis was carried out to examine the functions of modified bone tools.The results suggest that Lingjing bone tools were used for drilling,penetrating,and scraping animal substances,and that some might have been hafted during the use.This study confirms that early existence ofintentionally-modified bone tools at human occupations of the early Late Pleistocene in northern China.This discovery suggests making and use of bone tools were inevitably a part of early human behaviors and cultural development,as such of stone tools. | LI ZhanYang 1,4 & SHEN Chen 2,3,4 1 Henan Provincial Institute of Cultural Relics and Archaeology,Zhengzhou 450000,China 2 The Joint Laboratory of Human Evolution and Archaeometry,Chinese Academy of Sciences,Beijing 100044,China 3 The Royal Ontario Museum,Toronto ON M5S2C6,Canada 4 Oriental Archaeology Research Center of Shandong University,Jinan 250100,China | 2010 | Chinese Science Bulletin2010，55，21： | 4 |
| 4 | 材料参数与镍钛形状记忆合金的本构关系显示文摘在Tanaka模型基础上,我们讨论了形状记忆合金热力学特性的本构关系。特别注意了桓温拉伸过程和强迫回复过程。本构方程的材料参数,即弹性模量D,变化张量Ω,热力弹性张量均以镍钛合金实验测试值来确定。在不同的应力-应变-温度关系试验中发现D和Ω与温度之间有很强的相关性。 | Weijia Tang Rolf Sandstrom(Royal Institute of Technolog,Stockholm, Sweden) | 1995 | 医用生物力学1995，10，2： | 3 |
| 5 | ATMOSPHERIC CORROSION OF 304AND 316 STAINLESS STEELS显示文摘Atmospheric corrosion of 304 and 316 stainless steels was studied by field exposure test, in which rain water was collected and analyzed by atomic absorption spectroscope (AAS). Emphasis was put on the dissolution of chromium and nickel from the stainless steels by atmospheric corrosion and rain runoff. AAS analyses shows that the amounts of yearly chromium and nickel dissolution were less than 150ng/cm 2 and 50ng/cm 2 respectively for both 304 and 316 stainless steels. XPS analysis reveals the marked Cr enrichment on the 316 stainless steel after one year field exposure. SEM shows the morphology of corrosion pits on the steel surfaces. | J.S.Lu 1) , I.Odneval 2) and C.Leygraf 2) 1) College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, China 2) Department of Material Science and Engineering, Royal Institute of Technology, Stockholm, 100 44,Sw | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 3 |
| 6 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 7 | 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease显示文摘Back pain is a common condition with a high social impact and represents a global health burden.Intervertebral disc disease(IVDD)is one of the major causes of back pain;no therapeutics are currently available to reverse this disease.The impact of bone mineral density(BMD)on IVDD has been controversial,with some studies suggesting osteoporosis as causative for IVDD and others suggesting it as protective for IVDD.Functional studies to evaluate the influence of genetic components of BMD in IVDD could highlight opportunities for drug development and repurposing.By taking a holistic 3D approach,we established an aging zebrafish model for spontaneous IVDD.Increased BMD in aging,detected by automated computational analysis,is caused by bone deformities at the endplates.However,aged zebrafish spines showed changes in bone morphology,microstructure,mineral heterogeneity,and increased fragility that resembled osteoporosis.Elements of the discs recapitulated IVDD symptoms found in humans:the intervertebral ligament(equivalent to the annulus fibrosus)showed disorganized collagen fibers and herniation,while the disc center(nucleus pulposus equivalent)showed dehydration and cellular abnormalities.We manipulated BMD in young zebrafish by mutating sp7 and cathepsin K,leading to low and high BMD,respectively.Remarkably,we detected IVDD in both groups,demonstrating that low BMD does not protect against IVDD,and we found a strong correlation between high BMD and IVDD.Deep learning was applied to high-resolution synchrotron\iCJ image data to analyze osteocyte 3D lacunar distribution and morphology,revealing a role of sp7 in controlling the osteocyte lacunar 3D profile.Our findings suggest potential avenues through which bone quality can be targeted to identify beneficial therapeutics for IVDD. | Erika Kague Francesco Turci Elis Newman Yushi Yang Kate Robson Brown Mona S.Aglan Ghada A.Otaify Sarnia A.Temtamy Victor L.Ruiz-Perez Stephen Cross C.Patrick Royall P.Eckhard Witten Chrissy L.Hammond | 2021 | Bone Research2021，9，4： | 2 |
| 8 | Selenium and Iodine Deficiencies and Selenoprotein Function显示文摘This paper reviews some recent findings on the interactions between selenium deficiency and iodine deficency. Both micronutrients can control the levels of selenoprotein mRNAs, particularly in the thyroid and brain. When selenium and iodine supplies are limiting the compensatory mechanisms work to minimise adverse effects on thyroid hormone metabolsm and thus neurological developtnent. The mechanisms for regulation of selenoproteins in selenium and iodine deficiency are however very tissue-specific. For example, unlike the brain and thyroid,brown adipose tissue is unable to retain selenoproteins in selenium and iodine deficiency and is therefore at greater risk from injurious effects of the deficiencies. | JOHN R. ARTHUR FERGUS NICOL JULIE H. MITCHELL AND GEOFFREY J. BECKETT(Division Of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK Cellular Endocrinology Unit,University Department of Clinical Biochemistry, The Royal In | 1997 | Biomedical and Environmental Sciences1997，10，2： | 2 |
| 9 | something or nothing: minimalism in art and architecture显示文摘 | Royal Academy and AD International Forum | 1999 | Architecture Design1999，68，3： | 2 |
| 10 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 11 | Identification of an atyp- ical Grb2 carboxyl - terminal SH3 domain binding site in Gab docking proteins reveals Grb2 - dependent and - independent re- cruitment of Gabl to receptor tyrosine kinases显示文摘 | Lock LS Royal I Nanjokas MA | 2000 | J Biol Chem2000，275，31： | 1 |
| 12 | something or nothing:minimalism in art and architecture显示文摘 | | 1999 | Architecture Design1999，68，3： | 1 |
| 13 | Introducing the sandwich plate system: a new technique in shipbuilding 显示文摘 | Royal Institution of Naval Architects | 2000 | Naval Architect2000，11，11： | 1 |
| 14 | Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron显示文摘 | Brushart TM Hoffman PN Royall RM | 2002 | J Neurosci2002，22，15： | 1 |
| 15 | Solution calorimetry as a tool to study the neutralising capacity of magnesium trisilicate mixture BP and its components 显示文摘 | Gaisford S Royall P G Greig D G T | 2004 | Thermochimica Aeta2004，417，： | 1 |
| 16 | Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia显示文摘 | Roman GC Sachdev P Royall DR | 2004 | Neurol Sci2004，22，6： | 1 |
| 17 | LEACHING OF PRECIOUS METALS FROM COMPLEX SULPHIDE ORES——2.DIRECT LEACHING OF Cu SULFIDE CONCENTRATE BY ACIDIC THIOUREA SOLUTIONS显示文摘Recovery of gold and silver from a sulphide concentrate by thiourea leaching was investigat-ed.The effects of various parameters on the process,such as oxidants,the initial concentrationof thiourea and acidity in solutions as well as reaction temperature,were systematically exam-ined.From the results it was confirmed that(a)oxidants had no significant influence on the dis-solution of gold and silver at a fixed initial concentration of thiourea;(b)the initial concentra-tion of thiourea and acidity affected the dissolution rate only in the earliest period of leaching;(c)the rate of the process was controlled by reagent diffusion.The optimum operations wereworked out for the thiourea leaching process of the concentrate. | Fang,Zhaoheng Institute of Chemical Metallurgy,Academia Sinica,Beijing 100080Muhammed,Mamoun Royal Institute of Technology,S—100044 Stockholm,Sweden | 1993 | 中国有色金属学会会刊:英文版1993，3，4： | 1 |
| 18 | Sean,Symposium:Post-Chicago Economics:Editor's Note显示文摘 | Royall M | 1995 | Antitrust Law Journal1995，69，： | 1 |
| 19 | Qualify-of-life differences between prophylactic and on demand factor replacement therapy in European haemophilia patients显示文摘 | Royal S Schramm W Berntorp E | 2002 | Haemophilia2002，8，1： | 1 |
| 20 | Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol显示文摘 | Labrecque L Royal I Surprenant DS | 2003 | Mol Biol Cell2003，14，1： | 1 |
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