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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The bfl-1 gene is transcriptionally upregulated by the Epstein-Barr virus LMP1, and its expression promotes the survival of a Burkitt's lymphoma cell line显示文摘 | Dsouza B Rowe M Walls D | 2000 | J Virol2000，74，14： | 1 |
| 3 | Estimation of the Convection Heat Transfer Coefficient of Cool- ant within the Grinding gone显示文摘 | Jin T Stephenson D J Rowe W B | 2003 | Journal of Engi neering Manufacture2003，217，3： | 1 |
| 4 | A randomized, con -trolled trial of RSD1235, a novel anti-arrhythmic agent,in the Lrealment of recent onseL atrial fibrillation 显示文摘 | Roy D Rowe B H Stiell I G | 2004 | JAm Coll Cardiol2004，44，12： | 1 |
| 5 | The effects of infiltr-ation on the stability of a dry ash dump显示文摘 | FOURIE A B ROWE D BLIGHT G H | 1999 | Gé otechnique1999，49，1： | 1 |
| 6 | The role of extensive green roofs in sustainable development显示文摘 | Getter K L Rowe D B | 2006 | Hortscience2006，41，5： | 1 |
| 7 | Is the current BMI obesity classification appropriate for black and white post- menopausal women? 显示文摘 | EVANS E M ROWE D A GACETTE S B etal | 2006 | Int J Obes (Lond)2006，30，5： | 1 |
| 8 | High-temperature refractory metal-intermetallic composites显示文摘 | JACKSON M R BEWLAY B P ROWE R G SKELLY D W LIPSITT H A | 1996 | JOM1996，48，1： | 1 |
| 9 | Postoperative discitis:diagonosis and management显示文摘 | DALL B E ROWE D E ODETTE W G | 1987 | Clin Orthop1987，，224： | 1 |
| 10 | Effect of PEGylation on the solution conformation of antibody fragments显示文摘 | Lu Y Harding S E Turner A Smith B Athwal D S Grossmann J G Davis K G Rowe A J | 2008 | Journal of Pharmaceutical Sciences2008，97，6： | 1 |
| 11 | Effect of supplemental trace-mineral source on bull semen quality显示文摘 | Rowe M P Powell J G Kegley E B Lester T D Rorie R W | 2014 | Professional Animal Scientist2014，，1： | 1 |
| 12 | The role of extensive green roofs in sustainable development 显示文摘 | Getter K L Rowe D B | 2006 | Hort Science2006，41，5： | 1 |
| 13 | Green roof stormwater retention:Effects of roof surface, slope and media depth显示文摘 | Vanwoert N D Rowe D B Andresen J A | 2005 | Journal of Environmental Quallity2005，34，3： | 1 |
| 14 | A thermally coupled metal hydride hydrogen storage and fuel cell system 显示文摘 | MacDonald B D Rowe A M | 2006 | Journal of Power Sources2006，161，1： | 1 |
| 15 | Green roofs stormwater retention: effects of roof surface, slope and media depth 显示文摘 | van Woert N D Rowe D B Andresenm J A | 2005 | Journal of Environmental Quality2005，34，3： | 1 |
| 16 | Temperatures in deep grinding of finite workpieces显示文摘 | JIN Tan ROWE W B MCCORMACK D | 2002 | International Journal of Machine Tools & Manufacture2002，42，： | 1 |
| 17 | Temperature measurement in high efficiency deep grinding显示文摘 | BATAKO A D ROWE W B MORGAN M N | 2005 | International Journal of Machine Tools & Manufacture2005，45，： | 1 |
| 18 | Implications concerning rod bundle cross flow mixing based on measurements of turbulent flow structure显示文摘 | ROWE D S JOHNSON B M KNUDSEN J G | 1974 | International Journal of Heat and Mass Transfer1974，17，3： | 1 |
| 19 | Seven polymorphicmicrosatellite loci in honeybees (Apis mellifera) 显示文摘 | Rowe D J Rinderer T E Stelzer J A Oldroyd B P Crozier R H | 1997 | Insectes Sociaux1997，44，2： | 1 |
| 20 | FBG-based optical interface to support a multisector antenna in a spectrally efficient fibel radio system 显示文摘 | Marra C Nirmalathas A Lim C Attygalle M Novak D Ashton B Poladian L Rowe W S T Wang T Besley J A | 2004 | IEEE Photon Technol Lett2004，16，25： | 1 |
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