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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Endoscopic variceal band ligation compared with propranolol for prophylaxis of first variceal bleeding显示文摘 | Drastich P Lata J Petrtyl J | 2011 | Ann Hepatol2011，10，2： | 1 |
| 3 | Expression of Toll-like receptor 2 (TLR2) , TLR4, and CDI4 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis显示文摘 | FROLOVA L DRASTICH P ROSSMANN P | 2008 | J Histochem Cytochem2008，56，3： | 1 |
| 4 | Endoscopic variceal band ligation compared with propranolol for prophylaxis of first varical bleeding显示文摘 | DRASTICH P LATA J PETRTYL J | 2011 | Ann Hepatol2011，10，6： | 1 |
| 5 | Endoscopic variceal band ]igation compared with propranolol for prophylaxis of first variceal bleeding 显示文摘 | Drastich P Lata J Petrtyl J | 2011 | Ann Hepatol2011，10，2： | 1 |
| 6 | Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel disease显示文摘 | Drastich P Frolova-Brizova L Zanvit P | 2011 | Folia Microbiol (Praha)2011，56，3： | 1 |
| 7 | Endoscopic variceal band ligation compared with propranolol for prophylaxis of first variceal bleeding显示文摘 | Drastich P Lata J Petrtyl J | 2011 | Ann Hepatol2011，10，6： | 1 |
| 8 | Endoscopic variceal band ligation compared with propranolol for prophylaxis of first variceal bleeding显示文摘 | Drastich P Lata J Petrtyl J | | 0，，： | 1 |
| 9 | Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel disease显示文摘 | Drastich P Frolova-Brizova L Zanvit P | 2011 | Folia Microbiol (Praha)2011，56，： | 1 |
| 10 | Endoscopic variceal band ligation compared with propranolol for prophylaxis of first variceal bleeding显示文摘 | DRASTICH P LATA J PETRTYL J BRUHA R PROCHAZKA V VANASEK T | 2011 | Ann Hepatol2011，10，： | 1 |
| 11 | Endoscopic varieeal band? ligation? compared with propranolol for prophylaxis of first variceal bleeding显示文摘 | Drastich P Lata J Petrtyl J | 2011 | Ann Hepatol2011，10，2： | 1 |
| 12 | Endoscopic variceal band ligation compared with propranolol for prophylaxis of first variceal bleeding显示文摘 | Drastich P Lata J Petrtyl J | | 0，，02： | 1 |
| 13 | Expression of Toll-like receptor 2 (TLR2),TLR4 and CD14 in biopsy samples of patients with inflammatory bowel disease:up- regulated expression of TLR2 in terminal ileum of patients with ulcerative colitis 显示文摘 | Frolova L Drastich P Rossmann P | 2008 | J Histochem Cytochem2008，56，3： | 1 |
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