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| 1 | Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding显示文摘A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined processes.Here,three-dimensional(3D)printed polymer molds are used to construct multilayer poly(dimethylsiloxane)(PDMS)devices by employing unique molding,bonding,alignment,and rapid assembly processes.Specifically,a novel single-layer,two-sided molding method is developed to realize two channel levels,non-planar membranes/valves,vertical interconnects(vias)between channel levels,and integrated inlet/outlet ports for fast linkages to external fluidic systems.As a demonstration,a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure,illustrating a high degree of flow rate control.In addition,multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic channels.Using integrated alignment marks to accurately position both stamps and individual layers,this technique is demonstrated by rapidly assembling a six-layer microfluidic device.By combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS,this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems. | Casey C.Glick Mitchell T.Srimongkol Aaron J.Schwartz William S.Zhuang Joseph C.Lin Roseanne H.Warren Dennis R.Tekell Panitan A.Satamalee Liwei Lin | 2016 | Microsystems & Nanoengineering2016，2，1： | 4 |
| 2 | Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?显示文摘In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning goals.Pediatricians may play a key role in helping children access special education services.The number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to 2021.Children receiving special education services under the autism category increased 242%during the same period.The demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%respectively.Although student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by 2021.Allowable heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing processes.Numerous clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder epidemics.Dietary heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across generations.In 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative action.Mandatory health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations. | Renee J Dufault Raquel A Crider Richard C Deth Roseanne Schnoll Steven G Gilbert Walter J Lukiw Amanda L Hitt | 2023 | World Journal of Clinical Pediatrics2023，12，2： | 1 |
| 3 | Hypertension in children and adolescents 显示文摘 | Luma GB Roseann T | 2006 | Am Faro Physician2006，73，9： | 1 |
| 4 | Modification of acute cardiovascular homeostatic responses to hemorrhage following mild to moderate traumatic brain injury显示文摘 | C Geraldine McMahon RoseAnne Kenny Kathleen Bennett Emrys Kirkman | 2008 | Critical Care Medicine2008，，1： | 1 |
| 5 | Developing a National Index of Subjective Wellbeing: The Australian Unity Wellbeing Index显示文摘 | Robert A. Cummins Richard Eckersley Julie Pallant Jackie van Vugt RoseAnne Misajon | 2003 | Social Indicators Research2003，，2： | 1 |
| 6 | 9-cis-retinoids: Biosynthesis of 9-cis-retinoic acid显示文摘 | Jisun Paik Silke Vogel Roseann Piantedosi | 2000 | Biochemistry2000，39，27： | 1 |
| 7 | Hypertension in children andadolescents显示文摘 | Gregory B Luma Roseann T | 2006 | American Family Physician2006，73，9： | 1 |
| 8 | 9-cis-retinoids:Biosynthesis of 9-cis-retinoic acid显示文摘 | Jisun Paik Silke Vogel Roseann Piantedosi | 2000 | Biochemistry2000，39，27： | 1 |
| 9 | Removal of ammoniacal nitrogen from an artificial landfill leachate in downflow reed beds 显示文摘 | Roseanne Connolly Yaqian Zhao Guangzhi Sun | 2004 | Process Biochemistry2004，，39： | 1 |
| 10 | Seed dispersal and dormancy patterns in northern willows:ecological and evolutionary significance显示文摘 | Roseann D John Z | 1983 | CanadaJournal of Botany1983，61，： | 1 |
| 11 | An immortalized rat liver stellate cell line (HSC-T6):A new cell model for the study of retinoid metabolism in vitro显示文摘 | Silke Vogel Roseann Piantedosi Jorge Frank | 2000 | J Lipid Res2000，41，： | 1 |
| 12 | Collaborative E-mail exchange for teaching secondary ESL: A case study in Hong Kong 显示文摘 | Greenfield Roseanne | 2003 | Language learning & Technology2003，7，： | 1 |
| 13 | Air pollution and climate change co-benefit opportunities in the road transportation sector in Durban, South Africa显示文摘 | Thambiran Tirusha Diab Roseanne D | 2011 | Atmospheric Environment2011，45，： | 1 |
| 14 | Dietary Flavonoids and the Risk of Colorectal Cancer显示文摘 | Evropi T Janet K Roseanne C | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，4： | 1 |
| 15 | Occupational therapy using a sensory integrative appraoch for children with development disabilities 显示文摘 | Roseann CS Lucy JM | 2005 | MentalRetardation and Developmental Disabilities Research Reviews2005，4，11： | 1 |
| 16 | Dietary flavonoids and the risk of colorectal cancer显示文摘 | EVROPI T JANET K ROSEANNE C | 2007 | Cancer Epidemiol Biomarkers Prev2007，16，4： | 1 |
| 17 | Hypertension in chil- dren and adolescents显示文摘 | GREGORY B LUTMA ROSEANN T | 2006 | Am Faro Physician2006，73，9： | 1 |
| 18 | Cellular Retinol-binding Protein Type Ⅲ Is Needed for Retinoid Incorporation into Milk显示文摘 | Roseann Piantedosi Norbert Ghyselinck William S.Blaner Silke Vogel | | 0，，25： | 1 |
| 19 | Multi-level implications of framing leadership perceptions as adynamic process显示文摘 | ROSEANNE J F ROBERT E K RACHEL S G | 2008 | The Leadership Quarterly2008，19，2： | 1 |
| 20 | Developing a National Index of Subjective Wellbeing: The Australian Unity Wellbeing Index显示文摘 | Robert A. Cummins Richard Eckersley Julie Pallant Jackie van Vugt RoseAnne Misajon | 2003 | Social Indicators Research2003，，2： | 1 |
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