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| 1 | Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity显示文摘Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. | Luca Elli Federica Branchi Carolina Tomba Danilo Villalta Lorenzo Norsa Francesca Ferretti Leda Roncoroni Maria Teresa Bardella | 2015 | World Journal of Gastroenterology2015，21，23： | 8 |
| 2 | palliative care and end-stage colorectal cancer management:The surgeon meets the oncologist显示文摘Colorectal cancer(CRC)is a common neoplasia in the Western countries,with considerable morbidity and mortality.Every fifth patient with CRC presents with metastatic disease,which is not curable with radical intent in roughly 80%of cases.Traditionally approached surgically,by resection of the primitive tumor or stoma,the management to incurable stageⅣCRC patients has significantly changed over the last three decades and is nowadays multidisciplinary,with a pivotal role played by chemotherapy(CHT).This latter have allowed for a dramatic increase in survival,whereas the role of colonic and liver surgery is nowadays matter of debate.Although any generalization is difficult,two main situations are considered,asymptomatic(or minimally symptomatic)and severely symptomatic patients needing aggressive management,including emergency cases.In asymptomatic patients,new CHT regimens allow today long survival in selected patients,also exceeding two years.The role of colonic resection in this group has been challenged in recent years,as it is not clear whether the resection of primary CRC may imply a further increase in survival,thus justifying surgeryrelated morbidity/mortality in such a class of shortliving patients.Secondary surgery of liver metastasis is gaining acceptance since,under new generation CHT regimens,an increasing amount of patients with distant metastasis initially considered non resectable become resectable,with a significant increase in long term survival.The management of CRC emergency patients still represents a major issue in Western countries,and is associated to high morbidity/mortality.Obstruction is traditionally approached surgically by colonic resection,stoma or internal by-pass,although nowadays CRC stenting is a feasible option.Nevertheless,CRC stent has peculiar contraindications and complications,and its long-term cost-effectiveness is questionable,especially in the light of recently increased survival.Perforation is associated with the highest mortality and remains mostly matter for surgeons,by abdominal lavage/drainage,colonic resection and/or stoma.Bleeding and other CRC-related symptoms(pain,tenesmus,etc.)may be managed by several mini-invasive approaches,including radiotherapy,laser therapy and other transanal procedures. | Renato Costi Francesco Leonardi Daniele Zanoni Vincenzo Violi Luigi Roncoroni | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 3 | Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model显示文摘AIM: To evaluate the interplay between gliadin and LoVo cells and the direct effect of gliadin on cytoskeletal patterns.METHODS: We treated LoVo multicellular spheroids with digested bread wheat gliadin in order to investigate their morphology and ultrastructure (by means of light microscopy and scanning electron microscopy), and the effect of gliadin on actin (phalloidin fluorescence)and the tight-junction protein occludin and zonula occluden-1.RESULTS: The treated spheroids had deep holes and surface blebs, whereas the controls were smoothly surfaced ovoids. The incubation of LoVo spheroids with gliadin decreased the number of intracellular actin filaments, impaired and disassembled the integrity of the tight-junction system.CONCLUSION: Our data obtained from an 'in vivolike' polarized culture system confirm the direct noxious effect of gliadin on the cytoskeleton and tight junctions of epithelial cells. Unlike two-dimensional cell culture systems, the use of multicellular spheroids seems to provide a suitable model for studying cell-cell interactions. | Ersilia Dolfini Leda Roncoroni Luca Elli Chiara Fumagalli Roberto Colombo Simona Ramponi Fabio Forlani Maria Teresa Bardella | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 4 | Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer显示文摘 | Leopoldo Sarli Giovanni Bader Domenico Iusco Carlo Salvemini Davide Di Mauro Antonio Mazzeo Gabriele Regina Luigi Roncoroni | 2004 | European Journal of Cancer2004，，2： | 2 |
| 5 | Cefamandole bone diffusion in patients undergoing total hip replacement显示文摘 | Roncoroni AJ Manuel C Nedjar C | 1981 | Chemother1981，27，3： | 1 |
| 6 | Small gallstones, acute pancreatitis, and prophylactic cholecystectomy 显示文摘 | Costi R Violi V Roncoroni L | 2006 | Am J Gastroenterol2006，101，7： | 1 |
| 7 | Cefamandole bone diffusion in patients undergoing total hip replacement 显示文摘 | Roncoroni AJ Manuel C Nedjar C | 1981 | Chemother1981，27，： | 1 |
| 8 | Preoperative endoscopic sphincterotomy and laparoscopic cholecystectomy for the management of cholecystocholedocholithiasis : 10 year experience 显示文摘 | Sarli L Iusco D R Roncoroni L | 2003 | World J Surg2003，27，： | 1 |
| 9 | Small gallstones,acute pancrea-titis,and prophylactic cholecystectomy显示文摘 | Costi R Violi V Roncoroni L | 2006 | Am J Gastroenterol2006，101，7： | 1 |
| 10 | Cryptosporidium infection in renal transplantpatients 显示文摘 | RONCORONI A J | 1989 | J Infect Dis1989，60，3： | 1 |
| 11 | Preoperative endoscopic sphinc-terotomy and laparoscopic cholecystectomy for the management显示文摘 | Sarli L Iusco DR Roncoroni L | 2003 | World J Surg2003，27，2： | 1 |
| 12 | Biofeedback Therapy Plus Anal Electrostimulation for Fecal Incontinence: Prognostic Factors and Effects on Anorectal Physiology显示文摘 | Adamo Stefano Boselli Ferdinando Pinna Stefano Cecchini Renato Costi Federico Marchesi Vincenzo Violi Leopoldo Sarli Luigi Roncoroni | 2010 | World Journal of Surgery2010，，4： | 1 |
| 13 | Preoperative endoscopic sphincterotomy and laparoscopic cholecystectomy for the management of cholecystocholedocholithiasis:10-year experience显示文摘 | Sarli L Iusco DR Roncoroni L | 2003 | World J Surg2003，27，2： | 1 |
| 14 | Influence of dilute acetic acid treatments on American pondweed winter buds in the Nevada irrigation district,California显示文摘 | Spencer D F Elmore C L Ksander G G Roncoroni J A | 2003 | J Aquat Plant Manage2003，41，： | 1 |
| 15 | Discriminant power and information content of Ranson's prognostic signs in acute pancreatitis: a meta-analytic study显示文摘 | De Bernardinis M Violi V Roncoroni L | 1999 | Crit Care Med1999，27，10： | 1 |
| 16 | Small gallstones, acute pancreatitis,and prophylactic cholecystectomy显示文摘 | Costi R Violi V Roncoroni L | 2006 | Am J Gastroentero12006，101，7： | 1 |
| 17 | Intraoperative cholangiography and bile duct injury 显示文摘 | Sarli L Costi R Roncoroni L | 2006 | Surg Endosc2006，20，1： | 1 |
| 18 | Verification of a protocol for inducing hypersplenism in the rat by means of methylcellulose显示文摘 | Roncoroni L Violi V Muri M | 1982 | Chir Patol Sper1982，29，4： | 1 |
| 19 | Resveratrol inhibits cell growth in a human cholangiocarcinoma cell line显示文摘 | Roncoroni L Elli L Dolfini E | 2008 | Liver International:Official Journal of the International Association for the Study of the Liver2008，28，10： | 1 |
| 20 | Intraoperative cholangiography and bile duct injury 显示文摘 | Sarli L Costi R Roncoroni L | 2006 | Surg Endosc2006，20，1： | 1 |
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