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| 1 | COVID-19-associated diarrhea显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)recently emerged as a highly virulent respiratory pathogen that is known as the causative agent of coronavirus disease 2019(COVID-19).Diarrhea is a common early symptom in a significant proportion of patients with SARS-CoV-2 infection.SARS-CoV-2 can infect and replicate in esophageal cells and enterocytes,leading to direct damage to the intestinal epithelium.The infection decreases the level of angiotensinconverting enzyme 2 receptors,thereby altering the composition of the gut microbiota.SARS-CoV-2 elicits a cytokine storm,which contributes to gastrointestinal inflammation.The direct cytopathic effects of SARS-CoV-2,gut dysbiosis,and aberrant immune response result in increased intestinal permeability,which may exacerbate existing symptoms and worsen the prognosis.By exploring the elements of pathogenesis,several therapeutic options have emerged for the treatment of COVID-19 patients,such as biologics and biotherapeutic agents.However,the presence of SARS-CoV-2 in the feces may facilitate the spread of COVID-19 through fecal-oral transmission and contaminate the environment.Thus gastrointestinal SARS-CoV-2 infection has important epidemiological significance.The development of new therapeutic and preventive options is necessary to treat and restrict the spread of this severe and widespread infection more effectively.Therefore,we summarize the key elements involved in the pathogenesis and the epidemiology of COVID-19-associated diarrhea. | Klara Megyeri Áron Dernovics Zaid I I Al-Luhaibi András Rosztóczy | 2021 | World Journal of Gastroenterology2021，27，23： | 2 |
| 2 | Ion beam synthesis of diamond-like carbon thin films containing copper nanocrystals 显示文摘 | Gerhards I Ronning C Hofsass H | 2003 | Journal of Applied Physics2003，93，2： | 1 |
| 3 | Integrating the mechanisms of apoptosis in- duced by endoplasmic reticulum stress 显示文摘 | Tabas I Ron D | 2011 | Nat Cell Biol2011，13，3： | 1 |
| 4 | Ion beam synthesis of amorphous carbon thin films containing metallic nanoclusters 显示文摘 | Gerhards I Ronning C Vetter U | 2002 | Surface and Coating Technology2002，，： | 1 |
| 5 | Framelets: MRA-based Constructions of Wavelet Frames 显示文摘 | Daubechies I Han B Ron A | 2003 | Applied Computational Harmonic Analysis2003，14，1： | 1 |
| 6 | Effect of glucose oxidase activity on corrosion potential of stainless steels in seawater 显示文摘 | DUPONTA I FI~RON D NOVEL G | 1998 | International Biodeterioration & Biodegradation1998，41，1： | 1 |
| 7 | From QTL to QTN identification in livestock- winning by points rather than knock out : a review 显示文摘 | Ron M Weller J I | 2007 | Anim Gen- et2007，38，： | 1 |
| 8 | Integrating the mechanisms of apoptosis in- duced by endoplasmic reticulum stress显示文摘 | TABAS I RON D | 2011 | Nat Cell Biol2011，13，3： | 1 |
| 9 | Integrating the mechanisms of apoptosis in- duced by endoplasmic reticulum stress显示文摘 | Tabas I Ron D | 2011 | Nat Cell Biol2011，13，3： | 1 |
| 10 | Tamoxifen inhibits topoisomerases,depletes mitochondrial DNA and triggers steatosis in mouse liver显示文摘 | Larosche I Lettéron P Fromenty B | | 0，，02： | 1 |
| 11 | Graph minimum linear arrangement by multilevel weighted edge contractions显示文摘 | Safro I Ron D Brandt A | 2006 | Journal of Algorithms2006，60，1： | 1 |
| 12 | Framelets:MRA-based constructions of wavelet frames显示文摘 | DAUBECHIES I HAN B RON A | 2003 | Appl Comput Harmon Anal2003，14，1： | 1 |
| 13 | Intrachromosomal recombination within the vsp locus of Mycoplasma bovis generates a chimeric variable surface lipoprotein antigen显示文摘 | Lysnyansky I Ron Y Sachse K | | 0，，06： | 1 |
| 14 | Detection performance prediction on IR images assisted by evolutionary learning显示文摘 | Ron P Harley R M | 1999 | SPIE1999，，3699： | 1 |
| 15 | Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress 显示文摘 | Tabas I Ron D | 2011 | Nat Cell Biol2011，13，3： | 1 |
| 16 | Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress 显示文摘 | Tabas I Ron D | 2011 | Nat Cell Biol2011，13，3： | 1 |
| 17 | Is the sampling site along the umbilical artery significant? 显示文摘 | Perhnan S Goldman RD Maatuk H Ron E Shinwell E Blick I | 2002 | Gynecol Obstet Invest2002，54，2： | 1 |
| 18 | Methotrexate in chronic active ulcerative colitis: A double-blind, randomized, Israeli multicenter trial显示文摘 | R Oren N Arber S Odes M Moshkowitz D Keter I Pomeranz Y Ron I Reisfeld E Broide A Lavy A Fich R Eliakim J Patz E Bardan Y Villa T Gilat | 1996 | Gastroenterology1996，，： | 1 |
| 19 | Integrating the mechanisms of apoptosis inducedby endoplasmic reticulum stress 显示文摘 | Tabas I Ron D | 2011 | Nat Cell Biol2011，13，3： | 1 |
| 20 | Hormone replacement therapy in breast cancer survivors:the Israeli Society for Clinical Oncology and Radiotherapy policy letter显示文摘 | Siegelmann-Danieli N Ron I Kaufman B | 2004 | Harefuah2004，141，75： | 1 |
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