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| 1 | Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection显示文摘AIM To demonstrate the relationship betweenH-ras oncogene and hepatocellular carcinoma(HCC) metastasis.METHODS Activated H-ras oncogene wastransfected into SMMC 7721, a cell line derivedfrom human HCC, by calcium phosphatetransfection method. Some metastasis-relatedparameters were detected in vitro, includingadhesion assay, migration assay, expression ofcollagenase ⅣV (c ⅣV ase) and epidermal growthfactor receptor (EGFR).RESULTS The abilities of H-ras-transfected cellclones in adhesion to laminin (LN) or fibronectin(FN), migration, c Ⅳ ase secretion increasedmarkedly, and the expression of EGFR elevatedmoderately. More importantly, these alterationswere consistent positively with the expressionof p21, the protein product of H-ras oncogene.CONCLUSION H-ras oncogene could inducethe metastatic phenotype of HCC cell in vitro toraise its metastatic potential. | Qing Wang~1 Zhi Ying Lin~2 Xiao Li Feng~3 ~1Department of Microbiology,Medical Center of Fudan University.the former Shanghai Medical University,Shanghai 200032,China ~2Liver Cancer Institute,Zhongshan Hospital,Shanghai 200032,China ~3Shanghai Institute of Biochemistry,Academy Sinica,Shanghai 200031,ChinaQing Wang earned master degree from Shanghai Medical University in 1996,now a senior lecturer of microbiology,specialized in the role of oncogcncs on tumor metastasis,having 8 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Response characteristics of an ascending auditory neuron AN3 and its projections in the brain of the bushcricket Gampsocleis grationsa显示文摘The phonotaxis of bushcrickets demonstrates that they have goodcapability of recognizing conspecific songs and locating the sound source,which bases on complicated auditory mechanisms of the central nervoussystem(CNS).This article describes the response characteristics of AN3,an auditory ascending neuron in the prothoracic ganglion,and its projec-tions within the brain.The AN3,with a quasi-tonic discharge pattern,has high sensitivity,directionality and ability to encode sound intensity.Therefore,it plays an important role in auditory information processingof CNS.Its projections in the brain are mainly concentrated in the lateralzone of the deutencephalon,where synaptically connecting local auditoryinterneurons in the brain. | GAO Panpan and SHEN Jun -Xian(Institute of Biophysics, Academia Sinica, Beijing 100080)The phonotaxis of bushcrickets demonstrates that they have good capability of recognizing conspecific songs and locating the sound source, which bases on complicated auditory mechanisms of the central nervous system (CNS). This article describes the response characteristics of AN3, an auditory ascending neuron in the prothoracic ganglion, and its projections within the brain. The AN3 , with a quasi-tonic discharge pattern, has high sensitivity, directionality and ability to encode sound intensity. Therefore, it plays an important role in auditory information processing of CNS. Its projections in the brain are mainly concentrated in the lateral zone of the deutencephalon, where synaptically connecting local auditory interneurons in the brain. | 1992 | Chinese Journal of Acoustics1992，11，1： | 3 |
| 3 | Endoscopy显示文摘 | Gay G Delvaux M Rey J E The role of video capsule endoscopy in the diagnosis of digestive diseases: a review of current possibilities | 2004 | Endoscopy2004，36，4： | 1 |
| 4 | Changes in microflora and biochemical composition dur- ing the baceman stage of traditional Indonesian kecap ( soy sauce) production显示文摘 | Roling Ling W F M Timotius K H Budhi Prasetyo A | 1994 | Journal of Fermentation and Bioen- gineering1994，77，1： | 1 |
| 5 | Physical factors influencing microbial interactions and bio- chemical changes during the baceman stage of Indonesian kecap (soy sauce) production显示文摘 | Roling Ling W F M Timotius K H Stouthamer A H | 1994 | Journal of Fermentation and Bioengineering1994，77，3： | 1 |
| 6 | Antifungal activities of fluconzale,caspofungin (MK099),and anidulafungin (LY303366) alone and in combination against candida spp and crytococcus neoformans via time-kill methods显示文摘 | ROLING EE KLEPSER M E WASSON A | 2002 | Diagn Microbiol Infect Dis2002，43，： | 1 |
| 7 | 6P challenge in DNA/MVA- vaecinated macaques显示文摘 | AMARA R R IBEGBU C VILLINGER F et ahStudies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89 | 2005 | Virology2005，343，2： | 1 |
| 8 | 显示文摘 | Hare Wood LM Webb DR Pope AJ Laparoscopic ureterolithtomy the result of an initial series and a evaluation of its role in the management of ureteric calculi | 1994 | Br J Urol1994，74，： | 1 |
| 9 | Low nitrifica- tion rates in acid Scots pine forest soils are due to pH-related factors显示文摘 | NUGROHO R A ROLING W F M LAVERMAN A M | 2007 | Microbial Ecology2007，53，1： | 1 |
| 10 | Quantification of spin-trapping Kinetics 显示文摘 | Shutova T Kriska T Nemeth A et aL Physicochemical modeling of the role of free radicals in photodynamic thera- py: V | 2000 | Bio- chem Biophys Res Commun2000，270，： | 1 |
| 11 | Neureg-ulin-1 type III determines the ensheathment fate of axons显示文摘 | Taveggia C Zanazzi G Petrylak A Yano H Rosenbluth J Einheber S Xu X Esper RM Loeb JA Shrager P Chao MV Fals DL Role L Salzer JL | | 0，，： | 1 |
| 12 | Effect of sucrose on the tl~ermomechanical behavior of concentrated wheat and waxy corn starch-water preparations 显示文摘 | Chiotelli E Rolee A Le Meste M | 2000 | Journal of Agricultural and Food Chemistry2000，48，4： | 1 |
| 13 | Effect of moisture content on thermomechanical behaviour of concentrated wheat starch -water preparations 显示文摘 | Rolee A LeMeste M | 1999 | Cereal Chemistry1999，，76： | 1 |
| 14 | Comparison between traditional and industrial soy sauce fcrmontation in Indonesia显示文摘 | ROLING WFM APRIYANTONO A VAN I-IW | 1996 | J Bioscl Bioeng1996，81，3： | 1 |
| 15 | 显示文摘 | Aizenberg J Hanson J Leiserowitz L Addadi L Morphogenesis of calcitic sponge spicules : a role for specialized proteins interacting with growing crystals Weiner S | 1995 | FASEB J 19951995，，： | 1 |
| 16 | in drought tolerance in wheat 显示文摘 | Hajheidari M Eivazi A Buchanan B Proteomics uncovers a role for redox B | 2007 | J Proteome Res2007，6，4： | 1 |
| 17 | Comparison between traditional and industrial soy sauce fermentation in Indonesia显示文摘 | ROLING WFM APRIYANTONO A VAN VERSEVELD HW | 1996 | Ferment Bioeng1996，81，3： | 1 |
| 18 | 显示文摘 | Saha A Kuzuhara T Echigo N New role of(-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin | 2010 | Cancer Prev Res(Phila)2010，3，8： | 1 |
| 19 | Int J Infect Dis显示文摘 | Hansen A Cameron S Liu Q Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Fac- tors: A Review | 2015 | 192015，19，： | 1 |
| 20 | Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2显示文摘 | Michelsen KS Aicher A Mohaupt M The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS) | 2001 | J Biol Chem2001，276，25： | 1 |
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