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| 1 | All-epiphyseal versus trans-epiphyseal screw fixation for tillaux fractures:Does it matter?显示文摘BACKGROUND Tillaux fractures occur primarily in adolescents due to the pattern of physeal closure and are classified as Salter-Harris type III physeal fractures.Operative management with screw fixation is recommended for more than 2 mm of displacement or more than 1 mm of translation.However,the efficacy and complications of trans-physeal vs all-physeal screw fixation have not been investigated extensively.AIM To compare the clinical and functional outcomes of trans-physeal(oblique)and all-epiphyseal(parallel)screw fixation in management of Tillaux fractures among pediatric patients.METHODS This was an ethics board approved retrospective review of pediatric patients who presented to our tertiary children’s care facility with Tillaux fractures.We included patients who had surgical fixation of a Tillaux fracture over a 10 year period.Data analysis included demographics,mode of injury,management protocols,and functional outcomes.The patients were divided into group 1(oblique fixation)and group 2(parallel fixation).Baseline patient characteristics and functional outcomes were compared between groups.Statistical tests to evaluate differences included Fisher’s Exact or Chi-squared and independent samples t or Mann Whitney tests for categorical and continuous variables,respectively.RESULTS A total of 42 patients(28 females and 14 males)were included.There were no significant differences in body mass index,sex,age,or time to surgery between the groups[IK2].Sports injuries accounted for 61.9%of the cases,particularly non-contact(57.1%)and skating(28.6%)injuries.Computed Tomography(CT)scan was ordered for 28 patients(66.7%),leading to diagnosis confirmation in 17 patients and change in management plan in 11 patients.[GRC3]Groups 1 and 2 consisted of 17 and 25 patients,respectively.For mid to long-term functional outcomes,there were 14 and 10 patients in groups 1 and 2,respectively.Statistical analysis revealed no significant differences in the functional outcomes,pain scores,or satisfaction between groups.No infections,non-unions,physeal arrest,or post-operative ankle deformities were reported.Two(4.8%)patients had difficulty returning to sports post-surgery due to pain.One was a dancer,and the other patient had pain while running,which led to hardware removal.Both patients had parallel fixation.Hardware removal for groups 1 and 2 were 4(23.5%)and 5(20.0%)patients,respectively.The reasons for removal was pain in 2 patients,and parental preference in the remaining.CONCLUSION This is the largest reported series of pediatric patients with Tillaux fractures comparing functional outcomes of different methods of screw fixation orientation to the physis,which showed no difference regarding functional outcomes. | Brett Heldt Isaiah Roepe Raymond Guo Elsayed Attia Ifeoma Inneh Vinitha Shenava Indranil Kushare | 2022 | World Journal of Orthopedics2022，13，2： | 2 |
| 2 | Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient显示文摘 | J. H. Velthuis W. W. Unger A. R. Slik G. Duinkerken M. Engelse A. F. Schaapherder J. Ringers C. Kooten E. J. Koning B. O. Roep | 2009 | Diabetologia2009，，3： | 1 |
| 3 | Autophagy is a cell death mechanism in Toxoplasma gondii 显示文摘 | Ghosh D Walton JL Roepe PD | 2012 | Cell Mierobiol2012，14，4： | 1 |
| 4 | Regulatory multitasking of tolerogenic dendritic cells-lessons taken from vitamin D3-treated tolerogenic dendritic cells显示文摘 | Nikolic T Roep BO | | 0，，： | 1 |
| 5 | Strong association of MuSK antibody-positive myasthcnia gravis and HLA-DR14 -DQ5 显示文摘 | Niks EH Kuks JB Roep BO | 2006 | Neurology2006，66，11： | 1 |
| 6 | HLA-Dq polymorphism and heteroplamay levels of the A3243G mitochondrial mutation in maternally inherited diabetes and deafness 显示文摘 | VANESSEN H E R ROEP B O HART L M etal | 2000 | Diabete Med2000，17，： | 1 |
| 7 | Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity 显示文摘 | Bouwman L H Roep B O Roos A | 2006 | Hum Immunol2006，67，45： | 1 |
| 8 | The role of T-cells in the pathogenesis of Type1 diabetes:From cause to cure显示文摘 | Roep BO | 2003 | Diabetologia2003，46，3： | 1 |
| 9 | Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus显示文摘 | Roep BO Verburgh CA | 2002 | Lupus2002，11，： | 1 |
| 10 | T Cell Assays and MIATA: The Essential Minimum for Maximum Impact显示文摘 | C.M. Britten S. Janetzki L.H. Butterfield G. Ferrari C. Gouttefangeas C. Huber M. Kalos H.I. Levitsky H.T. Maecker C.J.M. Melief J. O’Donnell-Tormey K. Odunsi L.J. Old T.H.M. Ottenhoff C. Ottensmeier G. Pawelec M. Roederer B.O. Roep P. Romero S.H. van der | 2012 | Immunity2012，，1： | 1 |
| 11 | The role of T-cells in the pathogenesis of Type 1 diabetes:from cause to cure显示文摘 | Roep BO | 2003 | Diabetologia2003，46，3： | 1 |
| 12 | Analysis of iontransport pertubations caused by human MDR1 protein overexpression显示文摘 | Roepe PD | 1997 | Blochemistry1997，36，11： | 1 |
| 13 | A novel transporter, Pfcrt, confers antimalarial drug resistanee显示文摘 | Howard EM Zhang H Roepe PD | 2002 | J Membr Biol2002，190，1： | 1 |
| 14 | The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure显示文摘 | Roep BO | 2003 | Diabetologia2003，46，3： | 1 |
| 15 | Diabetogenic T lymphocytes in human type 1 diabetes显示文摘 | Roep BO Peakman M | 2011 | Curr Opin Immunol2011，23，6： | 1 |
| 16 | The cell responses to autoantigen in IDDM.The search for the Holy Grail显示文摘 | Roep BO | | 0，，： | 1 |
| 17 | HLA class I epitope discovery in type 1 diabetes:independent and reproducible identification of proinsulin epitopes of CD8 T cells-report of the IDS T Cell Workshop Committee显示文摘 | Pinkse GG Boitard C Tree TI Peakman M Roep BO | | 0，，： | 1 |
| 18 | Pillow-beds: a new type of seismites? An example from Oligocene turbidite fan complex , Alicante显示文摘 | Roep T B Events A J | 1992 | Sedimentology1992，39，： | 1 |
| 19 | Solub le froms of intercellular ad hesion molecul-1 in insulin dependent diabertes mellitus显示文摘 | Roep BO Heidenthal E Vries RRP | | 0，，： | 1 |
| 20 | Susceptibility loci for complex regional pain syndrome显示文摘 | van de Beck WJ Roep BO van der Slik AR | 2003 | Pain2003，103，： | 1 |
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