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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 3 | Indirect enzyme-linked immunosorbent assay for the mycotoxin zearalenone显示文摘 | Liu M T Ram B P Hart L P and Pestka J J | 1985 | Appl Environ Microbiol1985，50，2： | 1 |
| 4 | Childhood mental ability and blood pressure at midlife: linking the Scottish mental survey 1932 and the midspan studies显示文摘 | Starr J M Taylor M D Hart C L | 2004 | J Hypertens2004，22，5： | 1 |
| 5 | Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro显示文摘 | Liaw L Almeida M Hart CE | 1994 | Circ Res1994，74，2： | 1 |
| 6 | Identification,cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human显示文摘 | Hart AH Hartley L Ibrahim M | 2004 | Dev Dyn2004，230，1： | 1 |
| 7 | Identification, cloning and expression analysis of the pluripotency promoting nanog genes in mouse and human显示文摘 | Hart AH Hartley L Ibrahin M | 2004 | Dev Dyn2004，230，1： | 1 |
| 8 | Renal function with enteric-coated mycophenolate sodium in combination with reduced and standard tacrolimus levels: results of a 6-month comparative study in de novo renal transplant recipients显示文摘 | Hart M Chan L Andres A | 2008 | Am J Transplant2008，8，58： | 1 |
| 9 | The effect of model similarity on girl's motor performance 显示文摘 | Meaney K S Griffin L K Hart M A | 2005 | Journal of Teaching Physical Education2005，24，： | 1 |
| 10 | The great leap: driving innovation from the base of the pyramid 显示文摘 | Hart S L Christensen C M | 2002 | MIT Sloan Management Review2002，44，1： | 1 |
| 11 | Angiogenesis inhibitors in the treatment of epithelial ovarian cancer 显示文摘 | Hart ES Wakabayashi M Leong L | 2013 | Curr Treat Options Oncol2013，14，1： | 1 |
| 12 | Use of otolith microchemistry and stable isotopes to investigate the ecology and anadromous migra tions of Northern Dolly Varden from the Egegik River,Bristol Bay,Alaska显示文摘 | Hart L M Bond M H May-McNally S L | 2015 | Environmental Biology of Fishes2015，98，6： | 1 |
| 13 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples 显示文摘 | Chuang J C Hart K Chang J S Boman L E Van Emon J M Reed A W | 2001 | Analytica Chimica Acta2001，444，1： | 1 |
| 14 | Determination ofsugars in yogurt and microbiological media by high performance liquidchromatography during processing and subsequent storage显示文摘 | RICHMOND M L HARTE B R GRAY J I | 1987 | Journal ofDairy Science1987，70，6： | 1 |
| 15 | Surface area congruence of atlas superior articulating facets and occipital condyles显示文摘 | Briggs L Hart J Navis M | 2008 | J Chiropr Med2008，7，1： | 1 |
| 16 | Meta-analysis:An- tithrombotic therapy to prevent stroke in patients who have nonval- vular aria| fibrillation 显示文摘 | HART R G PEARCE L A AGUILAR M I | 2007 | Ann Intern Med2007，146，12： | 1 |
| 17 | Personality and organizational health:The role of conscientiousness显示文摘 | MILLER R L GRIFFIN M A HART P M | 1999 | Work and Stress1999，13，1： | 1 |
| 18 | Mechanisms of action of probiotics:recent advances显示文摘 | NG S C HART A L KAMM M A | 2009 | Inflamm Bowel Dis2009，15，2： | 1 |
| 19 | The great disruption 显示文摘 | Christensen C M Craig T Hart S L | 2001 | Foreign Policy2001，80，2： | 1 |
| 20 | Optimal guaranteed cost control of uncertain linear system with input constrains 显示文摘 | Y Li Q L Hart M X Sun | 2005 | International Journal of Control Automation and Systems2005，3，3： | 1 |
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