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| 1 | Usefulness of duodenal biopsy during routine upper gastrointestinal endoscopy for diagnosis of celiac disease显示文摘瞄准:在一张成年西班牙的人口在平淡的上面的胃肠的内视镜检查法期间在十二指肠的活体检视性能描述趋势,并且在临床的实践为乳糜泻的诊断分析它的值。方法:在当承担上面的胃肠的内视镜检查法时,执行的十二指肠的活体检视的 15 年趋势(1990 ~ 2004 ) 被学习。我们与贫血症或长期的腹泻在全面的组,并且在亚群分析了乳糜泻的流行。结果:十二指肠的活体检视在 13 678 上面的胃肠的内视镜检查法(7.6%) 中的 1033 个被执行;这的使用的增加在学习时期上被观察(1.9% 在 1990-1994, 5% 在 1995-1999 并且 12.8% 在 2000-2004 ) 。乳糜泻在 22 个病人(2.2%) 被诊断,这比在男人在女人是更经常的(3% 和 1% 分别地) 。十四从 514 (2.7%) 有贫血症的病人, 12 从 141 (8.5%) 与长期的腹泻并且 8 (19%) 从 42,与贫血症,正长期的腹泻有乳糜泻。一个古典临床的演讲在 55% 盒子中被观察, 23% 病人联系了疱疹样皮炎和 64% 介绍贫血症;9% 被家庭屏蔽诊断并且 5% 由秘密成员基因 hypertransaminasaemia。结论:在成年人在平淡的上面的胃肠的内视镜检查法期间承担的十二指肠的活体检视,逐渐地被合并了到临床的实践,并且是为在象有贫血症或长期的腹泻的那些那样的高风险组的乳糜泻的诊断的一个有用工具。 | S Riestra F Domínguez E Fernández-Ruiz E García-Riesco R Nieto E Fernández L Rodrigo | 2006 | World Journal of Gastroenterology2006，12，31： | 4 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Peroxisome proliferator activated receptor up-regulates the bcl-2 anti- apoptosis protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis 显示文摘 | Karen F Rodrigo Q Patricio R | 2007 | J Biolcham2007，282，37： | 1 |
| 4 | Coffee oil as a potential feedstock for biodiesel production显示文摘 | Leandro S O Adriana S F Rodrigo R S C | 2008 | Bioresource Technology2008，，99： | 1 |
| 5 | Direct synthesis of A2(Ti1-yZry)2O7(A=Gd3+,Y3+) solid solutions by ball milling constituent oxides显示文摘 | MORENO K J RODRIGO R S FUENTES A F | 2005 | J Alloys Compounds2005，390，12： | 1 |
| 6 | Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial显示文摘 | Christina Davies Hongchao Pan Jon Godwin Richard Gray Rodrigo Arriagada Vinod Raina Mirta Abraham Victor Hugo Medeiros Alencar Atef Badran Xavier Bonfill Joan Bradbury Michael Clarke Rory Collins Susan R Davis Antonella Delmestri John F Forbes Peiman Hadd | 2012 | The Lancet2012，，： | 1 |
| 7 | 53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases:new results for an old question显示文摘 | Cabanillas R Rodrigo JP Dominguez F P | 2007 | Cancer2007，109，9： | 1 |
| 8 | Performance evaluation of collision-reaction interface and internal standardization in quadrupole ICP-MS measurements 显示文摘 | Rodrigo F S S Marcelo B B G Edenir R P | 2011 | Talanta2011，86，： | 1 |
| 9 | Data stream clustering: A survey显示文摘 | JONATHAN A S ELAINE R F~ RODRIGO C B | 2013 | ACM Computing Sur- veys2013，46，1： | 1 |
| 10 | Identification and partial characterization of the soybean-dust allergens involved in the Barcerona asthma epidemic 显示文摘 | Rodrigo M J Morell F Helm R M | 1990 | Allergy and Clinical Immunology1990，85，： | 1 |
| 11 | P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases:new results for an old question显示文摘 | Cabanillas R Rodrigo J P Astudillo A Dominguez F Suarez C Chiara M D | 2007 | Cancer2007，109，： | 1 |
| 12 | Analysis of a 30- year rainfall record (1967-1997) in semi-arid SE Spain for implications on vegetation显示文摘 | Lazaro R Rodrigo F S GutieHrrez L | 2001 | Journal of Arid Environments2001，48，： | 1 |
| 13 | Nonlinear Dynamic Modeling and Simulation of an Atmospheric Reentry Spacecraft 显示文摘 | Wu S F Rodrigo R | 2001 | Aerospace Science and Technology2001，，5： | 1 |
| 14 | Treatment of articular cartilage defects in athletes:an analysis of functional outcome and lesion appearance显示文摘 | BLEVINS F T STEADMAN J R RODRIGO JJ | 1998 | Orthopedics1998，21，7： | 1 |
| 15 | The role of oxidative stress in the pathophysiology of 显示文摘 | Rodrigo R Gonztilez J Paoletto F | 2011 | Hypertens Res2011，34，4： | 1 |
| 16 | Detection of Ellipses Using Modified Hough Transform 显示文摘 | Patricia M B MANSO Rodrigo F PRESTES and Mariane R PETRAGLIA | 2003 | IEEE International Symposium2003，，2： | 1 |
| 17 | Direct Synthesis of A22O7 (A=Gd3+,Y3+) Solid Solutions by Ball Milling Constituent Oxides显示文摘 | Karla J Moreno Silva Rodrigo R Antonio F Fuentes | 2005 | Journal of Alloys and Compounds2005，390，： | 1 |
| 18 | The role of oxidative stress in the pathophysiology of hypertension显示文摘 | Rodrigo R González J Paoletto F | | 0，，： | 1 |
| 19 | Conventional step- wise vs vital capacity rapid inhalation induction at two concentra- tion of sevoflurane 显示文摘 | Martin-Larrauri R Gilsanz F Rodrigo J | 2004 | Eur J Anaesthesiol2004，21，4： | 1 |
| 20 | The role of oxidative stress in the pathophysiology of hypertension显示文摘 | Rodrigo R Gonz61ez J Paoletto F | 2011 | Hyperten- sion Research Official Journal of the Japanese Society of Hypertension2011，34，4： | 1 |
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