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| 1 | Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer显示文摘AIM: To compare the efficacy of capecitabine and oxaliplatin (XELOX) with 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX6) in gastric cancer patients after D2 dissection. METHODS: Between May 2004 and June 2010, patients in our gastric cancer database who underwent D2 dissection for gastric cancer at the First Affiliated Hospital of Sun Yat-Sen University were retrospectively analyzed. A total of 896 patients were enrolled into this study according to the established inclusion and exclusion criteria. Of these patients, 214 received the XELOX regimen, 48 received FOLFOX6 therapy and 634 patients underwent surgery only without chemotherapy. Overall survival was compared among the three groups using Cox regression and propensity score matchedpair analyses. RESULTS: Patients in the XELOX and FOLFOX6 groups were younger at the time of treatment (median age 55.2 years; 51.2 years vs 58.9 years), had more undifferentiated tumors (70.1%; 70.8% vs 61.4%), and more lymph node metastases (80.8%; 83.3% vs 57.7%), respectively. Overall 5-year survival was 57.3% in the XELOX group which was higher than that (47.5%) in the surgery only group (P = 0.062) and that (34.5%) in the FOLFOX6 group (P = 0.022). Multivariate analysis showed that XELOX therapy was an independent prognostic factor (hazard ratio = 0.564, P < 0.001). After propensity score adjustment, XELOX significantly increased overall 5-year survival compared to surgery only (58.2% vs 44.2%, P = 0.025) but not compared to FOLFOX6 therapy (48.5% vs 42.7%, P = 0.685). The incidence of grade 3/4 adverse reactions was similar between the XELOX and FOLFOX6 groups, and more patients suffered from hand-foot syndrome in the XELOX group (P = 0.018). CONCLUSION: Adjuvant XELOX therapy is associated with better survival in patients after D2 dissection, but does not result in a greater survival benefit compared with FOLFOX6 therapy. | Ying Wu Zhe-Wei Wei Yu-Long He Roderich E Schwarz David D Smith Guang-Kai Xia Chang-Hua Zhang | 2013 | World Journal of Gastroenterology2013，19，21： | 14 |
| 2 | 胃癌腹膜种植瘤动物模型的构建显示文摘目的建立稳定实用的人胃癌鼠腹膜种植瘤模型。方法通过对裸鼠和SCID鼠腹腔注射胃癌细胞株AGS、NCI—N87和SNUl6构建腹膜种植瘤模型,比较不同细胞株模型成功率和生存期的差异。结果裸鼠腹腔种植5×106个AGS、NCI—N87和SNUl6细胞腹膜瘤形成率分别是(3/8、6/8和2/8;SCID鼠腹腔种植5×106个AGS、NCI—N87和SNUl6细胞,腹膜瘤形成率分别是0/6、6/6和6/6。SCID鼠腹膜瘤模型中位生存期:NCI—N87细胞组(10x10。)为74d;SNUl6细胞3个不同剂量组(10×106、20×106和40×106)分别为95、78和44d。结论SCID鼠腹腔种植(20—40)×106个SNUl6细胞可以构建稳定实用的胃癌腹膜种植瘤模型。 | 张常华 陈连周 Roderich Schwarz 曾文涛 吴英 魏哲威 何裕隆 | 2013 | 中华普通外科学文献(电子版)2013，7，5： | 3 |
| 3 | Extent of Lymph Node Retrieval and Pancreatic Cancer Survival: Information from a Large US Population Database显示文摘 | Roderich E. Schwarz MD David D. Smith PhD | 2006 | Annals of Surgical Oncology2006，，9： | 2 |
| 4 | Recurrence patterns after radical gastrectomy for gastric cancer: Prognostic factors and implications for postoperative adjuvant therapy显示文摘 | Roderich E. Schwarz Kathryn Zagala-Nevarez | 2002 | Annals of Surgical Oncology2002，，4： | 2 |
| 5 | PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer显示文摘 | Katherine T. Ostapoff Niranjan Awasthi Bercin Kutluk Cenik Stefan Hinz Keith Dredge Roderich E. Schwarz Rolf A. Brekken | 2013 | Molecular Cancer Therapeutics2013，，7： | 2 |
| 6 | Androgen Receptor Blockade in Experimental Combination Therapy of Pancreatic Cancer显示文摘 | Srivani Konduri Margaret A. Schwarz Danielle Cafasso Roderich E. Schwarz | 2007 | Journal of Surgical Research2007，，2： | 1 |
| 7 | Clinical impact of lymphadenectomy extent in resectable gastric cancer of advanced stage显示文摘 | Roderich E. Schwarz David D. Smith | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 8 | The dual PI3K/mTOR inhibitor NVP-BEZ235 enhances nab-paclitaxel antitumorresponse in experimental gastric cancer显示文摘 | Chang-Ηua Zhang Niranjan Awasthi Margaret Schwarz Roderich Schwarz | 2013 | International Journal of Oncology2013，，5： | 1 |
| 9 | Paint - Only Is Equivalent to Scrub - and - Paint in Preoper-ative Preparationof Abdominal Surgery Sites 显示文摘 | Joshua DI Ellenhom David D Smith Roderich E Schwarz etal | 2005 | J Am CoilSurg2005，201，5： | 1 |
| 10 | Outcome of Palliative Operations for Malignant Bowel Obstruction in Patients With Peritoneal Carcinomatosis From Nongynecological Cancer显示文摘 | Sarah L. Blair David Z. J. Chu Roderich E. Schwarz | 2001 | Annals of Surgical Oncology2001，，8： | 1 |
| 11 | Clinical impact of lymphadenectomy extent in resectable gastric cancer of advanced stage显示文摘 | Roderich E. Schwarz David D. Smith | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 12 | Extent of Lymph Node Retrieval and Pancreatic Cancer Survival: Information from a Large US Population Database显示文摘 | Roderich E. Schwarz David D. Smith | 2006 | Annals of Surgical Oncology2006，，9： | 1 |
| 13 | Recurrence patterns after radical gastrectomy for gastric cancer: Prognostic factors and implications for postoperative adjuvant therapy显示文摘 | Roderich E. Schwarz MD PhD Kathryn Zagala-Nevarez PA | 2002 | Annals of Surgical Oncology2002，，4： | 1 |
| 14 | Recurrence patterns after radical gastrectomy for gastric cancer,prognostic factors and implications for postoperative adjuvant therapy显示文摘 | Roderich E Schwarz Kathryn Zagala-Nevarez | | 0，，04： | 1 |
| 15 | Recurrence patterns after radical gastrectomy for gastric cancer: Prognostic factors and implications for postoperative adjuvant therapy显示文摘 | Roderich E. Schwarz MD PhD Kathryn Zagala-Nevarez PA | 2002 | Annals of Surgical Oncology2002，，4： | 1 |
| 16 | Clinical Impact of Lymphadenectomy Extent in Resectable Esophageal Cancer显示文摘 | Roderich E. Schwarz David D. Smith | 2007 | Journal of Gastrointestinal Surgery2007，，11： | 1 |
| 17 | Clinical impact of lymphadenectomy extent in resectable gastric cancer of advanced stage显示文摘 | Roderich E. Schwarz David D. Smith | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 18 | Systemic cytotoxic and biological therapies of colorectal liver metastases: expert consensus statement显示文摘 | Roderich E. Schwarz Jordan D. Berlin Heinz J. Lenz Bernard Nordlinger Laura Rubbia‐Brandt Michael A. Choti | | HPB0，，： | 1 |
| 19 | Recurrence patterns after radical gastrectomy for gastric cancer: Prognostic factors and implications for postoperative adjuvant therapy显示文摘 | Roderich E. Schwarz MD PhD Kathryn Zagala-Nevarez PA | 2002 | Annals of Surgical Oncology2002，，4： | 1 |
| 20 | Clinical impact of lymphadenectomy extent in resectable gastric cancer of advanced stage显示文摘 | Roderich E. Schwarz David D. Smith | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
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