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6篇 您的检索式：作者名="Martin Roderfeld"

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		题名	作者	年代	出处	被引量
	1	Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC显示文摘AIM:To investigate the proteolytic contribution of tumor-associated macrophages(TAM)in tumor invasion,we analyzed whether TAM at the invasive front of small HCC in Abcb4-/--mice show an enhanced expression of MMP-9. METHODS:Liver cryosections of the hepatocellular carcinoma(HCC)invasive front from 12 mo old Abcb4-/--mice were stained for collagen typeⅠand MMP-9 using Alexa488 and Alexa568 labeled secondary antibodies.Afterwards,the Alexa568 dye was bleached and the macrophage marker F4/80 was visualized using Alexa568 labeled secondary antibodies.Finally, photographs of the invasive tumor front were digitally overlaid and analyzed. RESULTS:After complete bleaching of the primary dye,specific fluorescence staining of a third antigen, here F4/80,was successfully performed on the same histological section.With this method,we were able to identify conglomerates of matrix metalloproteinase (MMP-9)expressing macrophages within the tumor capsule of HCC. CONCLUSION:MMP-9 expressing macrophages are involved in matrix remodelling at the invasive tumor front of HCC.The described staining protocol provides a simple yet powerful extension of conventional immuno-histochemistry,facilitating visualization of at least three different antigens plus nuclei in one single histological section.	Martin Roderfeld Timo Rath Frank Lammert Christian Dierkes Jürgen Graf Elke Roeb	2010	World Journal of Hepatology2010，2，5：	6
	2	Matrix metalloproteinase-13 is regulated by toll-like receptor-9 incolorectal cancer cells and mediates cellular migration显示文摘	Timo Rath Julia St?ckle Martin Roderfeld Annette Tschuschner Jürgen Graf Elke Roeb	2011	Oncology Letters2011，，3：	2
	3	TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease显示文摘	Timo Rath Katrin Menendez Menendez Marion Kügler Lisa Hage Christian Wenzel Richard Schulz Jürgen Graf Lutz N?hrlich Elke Roeb Martin Roderfeld	2012	Digestive and Liver Disease2012，，9：	1
	4	Expression of MMPs and TIMPs in liver fibrosis-a systematic review with special emphasis on anti-fibrotic strategies 显示文摘	Stefanle Hemmann Jurgen Graf Martin Roderfeld	2007	Journal of Hepatology2007，46，：	1
	5	Expression of MMPs and TIMPs in liver fibrosis – a systematic review with special emphasis on anti-fibrotic strategies显示文摘	Stefanie Hemmann Jürgen Graf Martin Roderfeld Elke Roeb	2007	Journal of Hepatology2007，，5：	1
	6	Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis显示文摘	Corinna Henkel Martin Roderfeld Ralf Weiskirchen	2006	Proteomics2006，6，：	1

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