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185篇 您的检索式:作者名="Robles L"
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1Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected.Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena 2007World Journal of Gastroenterology2007,13,3:18
2Post-traumatic hepatic artery pseudoaneurysm treated with endovascular embolization and thrombin injection显示文摘Post-traumatic hepatic artery pseudoaneurysm is unc-ommon,appearing in approximately 1%of hepatic trauma cases.Most are extrahepatic(80%)and have a late onset.Although they are usually asymptomatic, they should always be treated becasue of the high risk of complications,especially breakage.Currently the treatment of choice is endovascular embolization with coils or the exclusion of the pseudoaneurysm using other intravascular devices.Recently there have been accounts of a treatment that combines embolization with coils and image-guided percutaneous human thrombin injection.We present a case of post-traumatichepatic artery pseudoaneurysm that was successfully treated using this combined technique.Lloret Esta Francisco López Conesa Asunción Capel Alemán Antonio Robles Campos Ricardo Reus Pintado Manuel Marín Hernández Caridad 2010World Journal of Hepatology2010,2,2:9
3High-throughput genetic mapping in Arabidopsos thaliana显示文摘Ponce M R Robles P Micol J L 1999Mol Gen Genet1999,261,:2
4Twotone distortion in the basilar membrane of the cochlea 显示文摘ROBLES L RUGGERO M A RICH N C 1991Nature1991,349,:1
5Thermosphere dynamics: Contributions from the first 5 years of the Dynamics Explorer program显示文摘Killeen T L R G Roble 1988Rev Geophys1988,26,:1
6A method for the evaluation of the fatigue operational life of submarine pressure hulls 显示文摘Robles L B R Buelta M A Goncalves E 2000International Journal of Fatigue2000,22,:1
7Input Output coefficients importance: A fuzzy logic approach显示文摘Morillas A Robles L 2011International Journal of Uncertainty Fuzziness and Knowledge-Based Systems2011,19,6:1
8Biocatalysis : towards ever greener biodiesel production 显示文摘ROBLES - MEDINA A GONZ:LEZ - MORENO P A ESTEBAN - CERDAN L 2009Biotechnol Adv2009,27,4:1
9Production of triacylglycerols rich in palmitic acid at position 2 as intermediates for the synthesis of human milk fat substitutes by enzymatic acidolysis显示文摘JIM(E)NEZ M J ESTEBAN L ROBLES A 0,,:1
10Prospects for the commercial cloning of animals by nuclear transplantation 显示文摘Robl J M Stice S L 1989Theriogenology1989,31,:1
11Brain amino acids during hyponatremia in vivo: clinical observations and experimental studies显示文摘Massieu L Montiel T Robles G 2004Neurochem Res2004,29,1:1
12Synthesis of structured lipids by two enzymatic steps:ethanolysis of fish oils and esterification of 2-monoacylglycerols显示文摘MU(N)(I)O M M ROBLES A ESTEBAN L 0,,:1
13Characteristics of coal combustion products (CCPs) from Kentucky power plants, with emphasis on mercury content显示文摘Hower J C Robl T L Anderson C 2005Fuel2005,84,11:1
14Allostatic processes in the family 显示文摘Repetti R L Robles T F Reynolds B 2011Dev Psychopathol2011,23,3:1
15Production of triacylglycerols rich in palmitic acid at sn-2 position by lipase- catalyzed acidolysis显示文摘Jimenez M J Esteban L Robles A 2010Biochemical Engineering Journal2010,51,3:1
16Enzymatic production of human milk fat substitutes containing palmitic and docosahexaenoic acids at Sn-2 position and oleic acid at Sn-1,3 positions显示文摘ROBLES A JIM(E)NEZ M J ESTEBAN L 0,,:1
17Chylopericardium of neoplastic aetiology显示文摘ANDRADE S ROBLES L CASIMIRO C 1998Ann Oncol1998,9,:1
18Management of bronchiolitis in the emergency department: impact of evidence- based guidelines? 显示文摘Johnson L W Robles J Hudgins A 2013Pediatrics2013,131,1:1
19Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders:a severely deficient activity is specific for thrombotic thrombocytopenic purpura显示文摘 Robles R Alberio L 2002Blood2002,100,2:1
20Lipid extraction from the microalga Phaeodactylum tricornutum 显示文摘RAMIREZ F A ESTEBAN C L ROBLES M A 2007Eur J Lipid Sci Technol2007,109,2:1
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