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73篇 您的检索式:作者名="Robins R F"
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1Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki 2006World Journal of Gastroenterology2006,12,40:3
2Estimating time varying risk premier in the term structure: the ARCH-M model显示文摘Engle R F Lilien D M Robins R P 1987Econometrics1987,55,2:1
3Estimating time varying risk premia in the term structure:the ARCH-M model显示文摘Engle R F Lilien D M Robins R P 1987Econometrica1987,55,:1
4Estimating Time Varying Risk Premia in the Term Structure: The ARCH-M model 显示文摘ENGLE R F LILIEN D M ROBINS R P 1987Econometrica1987,,55:1
5Estimating time varying risk premia in the term structure: The ARCH-m model 显示文摘Engel R F Lilien D M Robins R F 1987Econometriea1987,,55:1
6Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A 2012Ann Rev Earth Planet Sci2012,40,:1
7Extrusion - induced changes to the chemical profile and viscosity generating properties of citrus fiber 显示文摘Redgwell R J Curti D Robin F 2011Journal of Agricuhural and Food Chemistry2011,59,15:1
8Estimating time-varying risk premia in the term structure:the arch-m model显示文摘 Lilien D M Robins R P 1987Econometrica1987,55,1:1
9Estimating time varying risk premia in the term structure: the ARCH-M model显示文摘ENGLE R F LILIEN D M ROBINS R P 1987Eeonometriea1987,55,2:1
10Bax crystal structures reveal how BH3domains activate Bax and nucleate its oligomerization to induce apoptosis显示文摘Czabotar P E Westphal D Dewson G Ma S Hockings C Fairlie W D Lee E F Yao S Robin A Y Smith B J Huang D C Kluck R M Adams J M Colman P M 2013Cell2013,152,3:1
11Corrosion mechanisms of austenitic stainless steels in nitric media used in re- processing plants 显示文摘Fauvet P Balbaud F Robin R 2008Journal of Nuclear Materials2008,375,:1
12Extrusion-Induced Changes to the Chemical Profile and Viscosity Generating Properties of Citrus Fiber显示文摘Redgwell R J Curti D Robin F 2011Journal of Agricultural and Food Chemistry2011,59,15:1
13Estimating time varying risk premia in the term structure: the ARCH-M Model 显示文摘Engle R F Lilien D M Robins R P 1987Econometrica1987,55,2:1
14Estimating Time Varying Risk Premia in the Term Structure: The ARCH-M Model显示文摘Engle R F Lilien D M Robins R P 1987Econometrica1987,55,2:1
15Life-span de- velopment of self-esteem and its effects on important life outcomes 显示文摘Orth U Robins R W Widaman K F 2012Journal of Personality and Social Psychology2012,102,6:1
16Estimating time varying risk premia in the term structure: the ARCH-M model 显示文摘ENGLE R F LILIEN D M ROBINS R P 1987Eeonometrica1987,55,:1
17显示文摘Delorme J F Schmid R Robin M 1971Journal of Physics1971,32,7:1
18Estimating time varying risk premia in the term structure:the ARCHM model显示文摘Engle R F Lilien D M Robins R P 1987Econometrica1987,55,2:1
19Music - evoked nostalgia: Affect, memory, and personality 显示文摘Barrett F S Grimm K J Robins R W 2010Emotion2010,10,:1
20Estimating time-varing risk premia in the term structure:The CARVCH-M model显示文摘Engle R F Lilien D M Robins R P 1987Econometrica1987,,55:1
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