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| 1 | Preassembly and ligand-induced restructuring of the chains of the IFN-γ receptor complex: the roles of Jak kinases, Statl and the receptor chains显示文摘 | Christopher D Krause Natasha Lavnikova Junxia Xie Erwen Mei Olga V Mirochnitchenko Yiwei Jia Robin M Hochstrasser Sidney Pestka | 2006 | Cell Research2006，16，1： | 7 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 4 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status 显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 5 | Maximum likelihood from incomplete data via the EM algorithm显示文摘 | Dempster A P Laird N M Robin D B | 1977 | Journal of the Royal Statistical Society1977，39，1： | 1 |
| 6 | Gemfibrozil for secondary prevention of cardiovascular events in mild to moderate chronic renal insufficiency显示文摘 | TONELLI M COLLINS D ROBINS S | 2004 | Kidney Int2004，66，3： | 1 |
| 7 | Estimating time varying risk premier in the term structure: the ARCH-M model显示文摘 | Engle R F Lilien D M Robins R P | 1987 | Econometrics1987，55，2： | 1 |
| 8 | Effect of temperature and disinfection strategies on ammonia-oxidizing bacteria in a benchscale drinking water distribution system显示文摘 | Katarina D M Pintar Robin M | 2003 | Water Research2003，37，8： | 1 |
| 9 | Estimating time varying risk premia in the term structure:the ARCH-M model显示文摘 | Engle R F Lilien D M Robins R P | 1987 | Econometrica1987，55，： | 1 |
| 10 | Emergency nursing:Historical,current,and future roles显示文摘 | JOHN A SCHRIVER M D ROBIN TALMADGE R N | 2003 | Journal of Emergency Nursing2003，29，5： | 1 |
| 11 | Estimating Time Varying Risk Premia in the Term Structure: The ARCH-M model 显示文摘 | ENGLE R F LILIEN D M ROBINS R P | 1987 | Econometrica1987，，55： | 1 |
| 12 | Relationship of cytochromeoxidase activity to vertebrate total and organ oxygenconsumption 显示文摘 | Simon L M Robin E D | 1971 | Int J Biochem1971，2，： | 1 |
| 13 | Doppler ultrasound color flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Robin J M | 1990 | Ultrasond Med Biol1990，16，： | 1 |
| 14 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 15 | Estimating time varying risk premia in the term structure: The ARCH-m model 显示文摘 | Engel R F Lilien D M Robins R F | 1987 | Econometriea1987，，55： | 1 |
| 16 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 17 | Estimating time-varying risk premia in the term structure:the arch-m model显示文摘 | Lilien D M Robins R P | 1987 | Econometrica1987，55，1： | 1 |
| 18 | Estimating time varying risk premia in the term structure: the ARCH-M model显示文摘 | ENGLE R F LILIEN D M ROBINS R P | 1987 | Eeonometriea1987，55，2： | 1 |
| 19 | Relationship of cytoehrome oxidase activity to vertebrate total and organ oxygen consumption显示文摘 | SIMON M M ROBIN E D | 1971 | Journal of Biochemistry1971，2，： | 1 |
| 20 | Co-cultivationof CD4^+ and CD8^+ huamn T-cells leads to the appearance of CD4 cells expressing CD8 through denovo synthesis of the CD8 alpha-subunit显示文摘 | O'Donovan M R Jones D R Robins R A | 1999 | Hum Immunol1999，60，11： | 1 |
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