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| 1 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 2 | Mind Mapping as a flexible assessment tool 显示文摘 | Karen Goodnough Robin Long | 2002 | Assessment in Science: Practical Experiences and Education Research2002，，： | 1 |
| 3 | Pathogenesis of Varicose Veins显示文摘 | Rahmi Oklu Roy Habito Manuel Mayr Amy R. Deipolyi Hassan Albadawi Robin Hesketh T. Gregory Walker Katy R. Linskey Chandler A. Long Stephan Wicky Julianne Stoughton Michael T. Watkins | 2012 | Journal of Vascular and Interventional Radiology2012，，1： | 1 |
| 4 | Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function显示文摘 | S. Alice Long Mary Rieck Srinath Sanda Jennifer B. Bollyky Peter L. Samuels Robin Goland Andrew Ahmann Alex Rabinovitch Sudeepta Aggarwal Deborah Phippard Laurence A. Turka Mario R. Ehlers Peter J. Bianchine Karen D. Boyle Steven A. Adah Jeffrey A. Bluest | 2012 | Diabetes2012，，9： | 1 |
| 5 | Monthly streamflow simulation for Upper Changjiang Basin above the Three Gorges in China显示文摘 | TIAN-YU LONG MING-KO WOO ROBIN THORNE | 2008 | IAHS Publ2008，319，： | 1 |
| 6 | Making Canonical Workflow Building Blocks Interoperable across Workflow Languages显示文摘We introduce the concept of Canonical Workflow Building Blocks(CWBB),a methodology of describing and wrapping computational tools,in order for them to be utilised in a reproducible manner from multiple workflow languages and execution platforms.The concept is implemented and demonstrated with the BioExcel Building Blocks library(BioBB),a collection of tool wrappers in the field of computational biomolecular simulation.Interoperability across different workflow languages is showcased through a protein Molecular Dynamics setup transversal workflow,built using this library and run with 5 different Workflow Manager Systems(WfMS).We argue such practice is a necessary requirement for FAIR Computational Workflows and an element of Canonical Workflow Frameworks for Research(CWFR)in order to improve widespread adoption and reuse of computational methods across workflow language barriers. | Stian Soiland-Reyes Genis Bayarri Pau Andrio Robin Long Douglas Lowe Ania Niewielska Adam Hospital Paul Groth | 2022 | Data Intelligence2022，4，2： | 0 |
| 7 | 大规模无创产前检测的基因组分析揭示了多个性状的遗传关联、病毒的感染模式以及中国人群的遗传历史显示文摘文章简介本研究分析了参与无创产前基因检测(NIPT)的141,431名中国女性的全基因组低深度测序数据。研究团队使用这些数据描绘了中国人的群体遗传特征,并探索了遗传因素与母婴健康等性状的相互关联情况。 | Siyang Liu Shujia Huang Fang Chen Lijian Zhao Yuying Yuan Stephen Starko Francis Lin Fang Zilong Li Long Lin Rong Liu Yong Zhang Huixin Xu Shengkang Li Yuwen Zhou Robert W.Davies Qiang Liu Robin G.Walters Kuang Lin Jia Ju Thorfinn Korneliussen Melinda A.Yang Qiaomei Fu Jun Wang Lijun Zhou Anders Krogh Hongyun Zhang Wei Wang Zhengming Chen Zhiming Cai Ye Yin Huanming Yang Mao Mao Jay Shendure 汪建 Anders Albrechtsen 金鑫 Rasmus Nielsen 徐讯 | 2019 | 科学新闻2019，0，2： | 0 |
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