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您的检索式：作者名="Adam Hospital"
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| 1 | Effectsof the NovelGH Secretogogue, Hexarelin on GH Se-cretion and PhosphatidylinositolHydrolysis by Hum an Pitu-itary Som atotrophinom as in CellCulture显示文摘The effects of the novel GH releasing hexapeptide, Hexarelin, on cultured human pituitary somatotrophinomas were investigated. Hexarelin (0.01 - 100 nmol / L) dose dependently stimulated GH secretion up to 4.6 fold. Maximal effects occurred with 10 nmol / L. These effects were very similar to those observed with GHRP 6. The effects of Hexarelin were reduced by phloretin, an inhibitor of protein kinase C (PKC). The rate of phosphatidylinositol (PI) hydrolysis was markedly increased by Hexarelin in a dose dependent manner. These results demonstrated that Hexarelin could directly stimulate GH secretion by human pituitary somatotrophs in a PKC dependent manner, probably via activation of the PI transduction system. | LIU Qin1 , LEI Ting 2, LIU Kui 2, BAI Xiangjun 2, Eric Adams 3 1 Department of Pediatrics, Xiehe Hospital, Tongji Medical University, Wuhan 430022 2 Department of Neurosurgery, Tongji Hospital, Tongji Medical University, Wuhan 430030 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 1 |
| 2 | Making Canonical Workflow Building Blocks Interoperable across Workflow Languages显示文摘We introduce the concept of Canonical Workflow Building Blocks(CWBB),a methodology of describing and wrapping computational tools,in order for them to be utilised in a reproducible manner from multiple workflow languages and execution platforms.The concept is implemented and demonstrated with the BioExcel Building Blocks library(BioBB),a collection of tool wrappers in the field of computational biomolecular simulation.Interoperability across different workflow languages is showcased through a protein Molecular Dynamics setup transversal workflow,built using this library and run with 5 different Workflow Manager Systems(WfMS).We argue such practice is a necessary requirement for FAIR Computational Workflows and an element of Canonical Workflow Frameworks for Research(CWFR)in order to improve widespread adoption and reuse of computational methods across workflow language barriers. | Stian Soiland-Reyes Genis Bayarri Pau Andrio Robin Long Douglas Lowe Ania Niewielska Adam Hospital Paul Groth | 2022 | Data Intelligence2022，4，2： | 0 |
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