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| 1 | Pyruvate kinase M2 regulates homologous recombination- mediated DNA double-strand break repair显示文摘到 genotoxic 治疗的抵抗是治疗失败和肿瘤复发的一个主要原因。激活 DNA 损坏反应(DDR ) 并且允许癌症房间逃离 genotoxic 治疗的致命的效果的内在的机制仍然保持不清楚。这里,我们揭开通过的意外机制 pyruvate kinase M2 (PKM2 ) ,在癌症房间的高度表示的 PK isoform 和癌症的一个主人管理者新陈代谢的 reprogramming,与 DDR 集成直接支持 DNA 双海滨裂缝(DSB ) 修理。响应电离放射和氧化应力,在导致它的原子累积的 T328 的 ATM phosphorylates PKM2。pT328-PKM2 被要求并且对足够支持通过到在 DNA 的 DSB 和切除术的增加 CtIPs 招募的 T126 上的交往 CtBP 蛋白质(CtIP ) 的 phosphorylation 的调停的 DNA DSB 修理结束的相应再结合(HR ) 。ATM-PKM2-CtIP 轴的混乱敏化癌症房间到许多损坏 DNA 代理人和 PARP1 抑制。而且,增加了原子 pT328-PKM2 水平在 glioblastoma 病人与显著地更坏的幸存被联系。联合,这些数据倡导者是的指向 PKM2 策略的使用不仅破坏癌症新陈代谢而且禁止抵抗的重要机制到 genotoxic 治疗的一个工具。 | Steven T. Sizemore Manchao Zhang Ju Hwan Cho Gina M. Sizemore Brian Hurwitz Balveen Kaur Norman L. Lehman Michael C. Ostrowski Pierre A. Robe Weili Miao Yinsheng Wang Arnab Chakravarti Fen Xia | 2018 | Cell Research2018，28，11： | 5 |
| 2 | ZnO单晶的KOH碱液法生长和表征(英文)显示文摘采用自发成核方法,以KOH碱液作助熔剂,在银、镍和铁坩埚中分别生长了透明、棕绿色和棕色的纤维锌矿氧化锌单晶。X射线衍射和电感耦合等离子体原子发射光谱分析表明:晶体的颜色与所含的杂质有关,这些杂质来源于所使用的坩埚。采用光致发光(photoluminescence,PL)光谱对所生长的晶体进行了表征,结果显示,从银坩埚中生长的氧化锌晶体质量较高,其室温下用325nm波长光激发的PL光谱显示381nm强的紫外发射峰。在此基础上,从200mL银坩埚中生长出了尺寸为φ3mm×34mm氧化锌晶体。 | 张素芳 王继扬 姚淑华 BOUGHTON Robe I 郑昌成 徐士杰 | 2010 | 硅酸盐学报2010，38，2： | 2 |
| 3 | Reproductive Biology and Prospects for Conservation of Caldesia parnassifolia (Alismataceae)——A Threatened Monocot in China显示文摘Caldesia parnassifolia (Bassi ex Linn.) Parl. in China has declined in number in r ecent years and is increasingly faced with the risk of extirpation arising from anthropogenic changes associated with rapid urbanization and expansion of both agriculture and infrastructure. To aid in provision of the data needed for effective conservation of the species, studies on the habitat, pollination ecology, and breeding system of C. parnassifolia were carried out on natural populations occurring in Southeastern China. Flowering in the study populations extended for more than eighty days beginning in early summer. Floral anthesis occurred in the morning hours and proceeded rapidly, lasting about 45 min. Flowers lasted ca. 8 h. Caldesia parnassifolia is self\|compatible; however autogamy resulted in lower seed set than geitonogamy and xenogamy as well as free pollination. The data on pollen/ ovule (P∶O) ratio is consistent with a partially selfing and outcrossing mating system. Interpopulational crosses yielded similar seed set to within\|population crosses. Agamospermy did not occur in the study populations. Propagation is achieved through seeds as well as through turions which commonly occur in the inflorescences. Flies (Insecta; Diptera) were the most frequent visitors to the flowers of C. parnassifolia; however bees (Insecta; Hymenoptera) composed a larger proportion of effective pollinators. The Syrphidae species Sphaerophoria indiana (Bigot) presents evidence of oligolectic foraging behavior. Recommendations are made on the immediate steps necessary for conservation of Caldesia species in China. | Gituru Wahiti Robe rt, Wang Qing\|feng , Wang Yong, Guo You\|hao Colleg e of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China | 2003 | Wuhan University Journal of Natural Sciences2003，8，01A： | 2 |
| 4 | Extraction of DNA from soil显示文摘 | ROBE P NALIN R CAPELLANO C | 2003 | European Journal of Soil Biology2003，39，： | 1 |
| 5 | The impact of illegal insider trading in dealer and specialist markets: Evidence from a natural experiment显示文摘 | Raymond P H Fishe Michel A Robe | 2004 | Journal of Financial Economics2004，71，： | 1 |
| 6 | Oogenesis in teleosts:How fish eggs are formed显示文摘 | Esther Lubzens Graham Young Julien Robe | 2010 | General and Comparative Endocrinology2010，165，： | 1 |
| 7 | An Overview of Object Oriented Simulation显示文摘 | Chell A Robe s Yasser M Dessouky | 1998 | SimuJation1998，70，6： | 1 |
| 8 | Direct enzymelinked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorptional显示文摘 | Woitqe H Hesiey R | 1994 | J Bone Miner Res1994，9，10： | 1 |
| 9 | Safety oflong-acting hydropyridinge calcium channel blockers in hy-pertensive patients显示文摘 | Robe AK Gerge WV Barry JM | 2003 | Am J Cardiol2003，，81： | 1 |
| 10 | Dexamethasone inhibits the HSV-tk/ganciclovir bystander effect in malignant glioma cells显示文摘 | Robe PA Nguyen-Khac M Jolois O | | 0，，： | 1 |
| 11 | Ribuzyme knockdown functionally links a 1,25 ( OH ) 2 D3 membrane binding protein ( 1, 25D3-MARRS) and phosphate uptake in intestinal cells显示文摘 | Nemere I Faraeh-earson MC Robe B | 2004 | Proc Natl Acad Sci USA2004，101，19： | 1 |
| 12 | 3D XFEM-based modeling of retraction for preoperative image update显示文摘 | Vigneron LM Warfield SK Robe PA | 2011 | Comput Aided Surg2011，16，3： | 1 |
| 13 | Molecular and cell biology of TGF-B显示文摘 | Anita B Robe S | 1998 | Miner and ElectrolyteMetab1998，24，： | 1 |
| 14 | Motivation and goal orientation in vulnerabili- ty to depression显示文摘 | Vergara C Robes J E | 2011 | Cogn Emot2011，25，12： | 1 |
| 15 | Effects of Schwann cell transplantation in a contusion model of rat spinal cord injury显示文摘 | Martin D Robe P Franzen R | 1996 | J Neurosci Res1996，45，： | 1 |
| 16 | Phosphates and muscle fiber type influence the maltansitions porcine salt-soluble protein aggregation显示文摘 | ROBE G H XIONG Y L | 1992 | Journal of Food Science1992，57，： | 1 |
| 17 | Association of Aspirin Dose and Vorapaxar Safety and Efficacy in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome (From the TRACER Trial)显示文摘 | Kenneth W. Mahaffey Zhen Huang Lars Wallentin Robert F. Storey Lisa K. Jennings Pierluigi Tricoci Harvey D. White Paul W. Armstrong Philip E. Aylward David J. Moliterno Frans Van de Werf Edmond Chen Sergio Leonardi Tyrus Rorick Claes Held John Strony Robe | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 18 | Regulation of tissue inhibitor of metalloproteinases gene expression by cytokines and dexama methasone in rat hepatocyte primary cultures显示文摘 | Graeve L Hoffm oan R etal | 1993 | Hepatology1993，18，16： | 1 |
| 19 | The role of reduction and in- temal fixation of Lisfrane fracture - dislocations : a systematic review of the literature显示文摘 | Stavlas P Robes CS Xypnitos FN | 2010 | Int Orthop2010，8，： | 1 |
| 20 | Testing For Nonlinearities in German Bank Stock Returns显示文摘 | Kosfeld R Robe S | 2001 | Empirical Economics2001，26，3： | 1 |
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