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| 1 | 非均布荷载作用下煤岩力学强度特性试验研究显示文摘考虑不同初始垂向应力、不同初始水平应力及不同应力转移速度条件,借助于自主研发的采动应力试验系统,研究了非均布荷载作用下煤岩体的力学强度特性。研究结果表明:煤岩外部损伤残余块体对煤岩内部力学承载能力具有强化作用,当初始垂向应力、初始水平应力、应力转移速度一定时,煤岩内部力学承载能力近似为煤岩外部力学承载能力的2倍;伴随初始垂向应力的增加,煤岩整体后期力学承载能力不断降低,且处于不同初始垂向应力范围,煤岩内、外部后期力学强度递减特征不同,当处于较小初始垂向应力范围时,煤岩外部后期力学强度递减量大于煤岩内部,当处于较大初始垂向应力范围时,煤岩外部后期力学强度递减量小于煤岩内部;初始水平应力越大,煤岩体的力学承载能力越高,且无论较小还是较大初始水平应力范围,煤岩内部后期力学强度增量总大于煤岩外部;伴随应力转移速度的增加,煤岩峰值强度不断升高,应力转移速度对煤岩内部区域力学性质的影响相对较大。 | 王晓 文志杰 MIKAEL Rinne 沈宝堂 谢军 | 2017 | 岩土力学2017，38，3： | 6 |
| 2 | Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs显示文摘 | John L. Rinn Michael Kertesz Jordon K. Wang Sharon L. Squazzo Xiao Xu Samantha A. Brugmann L. Henry Goodnough Jill A. Helms Peggy J. Farnham Eran Segal Howard Y. Chang | 2007 | Cell2007，，7： | 6 |
| 3 | Modelling fracture propagation and failure in a rock pillar under mechanical and thermal loadings显示文摘The spPillar Stability Experiment (APSE) was conducted to study the rock mass response in a heated rock pillar between two large boreholes. This paper summarizes the back calculations of the APSE using a two-dimensional (2D) fracture propagation code FRACOD. To be able to model all the loading phases of the APSE, including the thermal loading, the code was improved in several ways. A sequential excavation function was developed to model promptly the stepwise changing loading geometry. Prior to the mod-elling, short-term compressive strength test models were set up aiming to reproduce the stress-strain behaviour observed for the sp diorite in laboratory. These models simulate both the axial and lateral strains of radial-controlled laboratory tests. The volumetric strain was calculated from the simulations and compared with the laboratory results. The pillar models include vertical and horizontal 2D models from where the stress in the pillar wall was investigated. The vertical model assesses the stability of the experimental rock volume and suggests the resultant stress below the tunnel floor in the pillar area. The horizontal model considers cross-sections of the pillar between the two large boreholes. The horizontal model is used to simulate the evolution of the stress in the rock mass during the excavation of the boreholes and during and the heating phase to give an estimation of the spalling strength. The modelling results suggest that the excavation-induced stresses will cause slight fracturing in the pillar walls, if the strength of the APSE pillar is set to about 123 MPa. Fracture propagation driven by thermal loading leads to minor spalling. The thermal evolution, elastic behaviour and brittle failure observed in the experiment are well reflected by the models. | Mikael Rinne Baotang Shen Tobias Backers | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，1： | 6 |
| 4 | 'Lnc'-ing enhancers to MYC regulation显示文摘 | Scott T Youner | 2014 | Cell Research2014，24，6： | 6 |
| 5 | Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer,therapeutic treatment options for platinum-resistant ovarian cancer显示文摘The survival rates for women with ovarian cancer have shown scant improvement in recent years,with a 5-year survival rate of less than 40%for women diagnosed with advanced ovarian cancer.High-grade serous ovarian cancer(HGSOC)is the most lethal subtype where the majority of women develop recurrent disease and chemotherapy resistance,despite over 70%-80%of patients initially responding to platinum-based chemotherapy.The phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signaling pathway regulates many vital processes such as cell growth,survival and metabolism.However,this pathway is frequently dysregulated in cancers including different subtypes of ovarian cancer,through amplification or somatic mutations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),amplification of AKT isoforms,or deletion or inactivation of PTEN.Further evidence indicates a role for the PI3K/AKT/mTOR pathway in the development of chemotherapy resistance in ovarian cancer.Thus,targeting key nodes of the PI3K/AKT/mTOR pathway is a potential therapeutic prospect.In this review,we outline dysregulation of PI3K signaling in ovarian cancer,with a particular emphasis on HGSOC and platinum-resistant disease.We review pre-clinical evidence for inhibitors of the main components of the PI3K pathway and highlight past,current and upcoming trials in ovarian cancers for different inhibitors of the pathway.Whilst no inhibitors of the PI3K/AKT/mTOR pathway have thus far advanced to the clinic for the treatment of ovarian cancer,several promising compounds which have the potential to restore platinum sensitivity and improve clinical outcomes for patients are under evaluation and in various phases of clinical trials. | Natasha Rinne Elizabeth LChristie Anastasia Ardasheva Chun Hei Kwok Nikita Demchenko Caroline Low Catherine Tralau-Stewart Christina Fotopoulou Paula Cunnea | 2021 | Cancer Drug Resistance2021，4，3： | 3 |
| 6 | The morality of software piracy: A cross-cultural analysis显示文摘 | W. R. Swinyard H. Rinne A. Keng Kau | 1990 | Journal of Business Ethics1990，，8： | 2 |
| 7 | The utility of a somatostatintype receptor binding peptide radiopharmaceutical (P829)in the evaluation of solitary pulmonary nodules 显示文摘 | Blum JE Handmaker H Rinne NA | 1999 | Chest1999，115，1： | 1 |
| 8 | Nitrous Oxide Emissions from a Municipal Landfill显示文摘 | Rinne J Pihlatie M Lohila A | 2005 | Environmental Science & Technology2005，，39： | 1 |
| 9 | Annual cycle of methane emission from a boreal fen measured by the eddy covariance technique显示文摘 | RINNE J RIUTTA T PIHLATIE M | 2007 | Tellus2007，59，： | 1 |
| 10 | Analysis of 561 patients with 690 middle artery aneurysms:anatomic and clinical features as correlated to management outcome显示文摘 | Rinne J Hernesniemi J Niskanen M | 1996 | Neurosurgery1996，38，： | 1 |
| 11 | Resistograph and X-raydensity charts of wood:Comparative evaluation of drillresistance profiles and X-ray density charts of different woodspecies显示文摘 | Rinn F Schweingruber F H schr E | 1996 | Holzforschung(Internal Journal of Biology Chemistry Physics and Technology of Wood)1996，50，4： | 1 |
| 12 | The mismatch negativity (MMN) in basic research of central auditory processing:A re-view显示文摘 | N(a)(a)tanen R Paavilainen R Rinne T | 2007 | Clin Neurophysiol2007，118，： | 1 |
| 13 | Functional demarcation of active and silent chromatin domains in human HOX loci by non- coding RNAs显示文摘 | Rinn JL Kertesz M Wang JK | 2007 | Cell2007，129，7： | 1 |
| 14 | RNA-protein interactions in human health and disease显示文摘 | Khalil AM Rinn JL | | 0，，04： | 1 |
| 15 | Assotiation of an interleukin 1B gene polymorphism(-511)with Parkinson's disease in Finnish patients显示文摘 | Rinne JO Lehtimaki T | 2002 | J Med Genet2002，39，6： | 1 |
| 16 | Inflam-matory cell and epithelial characteristics of perennialallergic and non-allergic rhinitis with a symptom his-tory of 1to 3years′duration显示文摘 | AMIN K RINNE J HAAHTELA T | 2001 | J Allergy Clin Immu-nol2001，107，： | 1 |
| 17 | Anti-inflammatory cytokine response and the development of multiple organ failure in severe sepsis显示文摘 | Loisa P Rinne T Laine S | 2003 | Acta Anaesthesiol Scand2003，47，3： | 1 |
| 18 | The pedunculopontine nucleus:its role in the genesis of movement disorders显示文摘 | Lee MS Rinne JO Marsden CD | 2000 | Yonsei Med J2000，41，2： | 1 |
| 19 | Effectiveness of pharmacotherapy for severe personality disorders:meta-analyses of randomized controlled trials显示文摘 | Ingenhoven T Lafay P Rinne T | 2010 | J Clin Psychiatry2010，71，： | 1 |
| 20 | Modular regulatory principles of large non- coding RNAs 显示文摘 | Guttman M Rinn JL | 2012 | Nature2012，482，7385： | 1 |
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