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| 1 | Role of antispasmodics in the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a long-lasting,relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits.Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis,both of which require effective treatment.Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission.Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades.Alverine citrate,a spasmolytic,decreases the sensitivity of smooth muscle contractile proteins to calcium,and it is a selective 5-HT1A receptor antagonist.Alverine,in combination with simethicone,has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial.Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis.Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control;nevertheless,in recent placebo-controlled studies,mebeverine did not exhibit superiority over placebo.Otilonium bromide is poorly absorbed from the GI tract,where it acts locally as an L-type calcium channel blocker,an antimuscarinic and a tachykinin NK2receptor antagonist.Otilonium has effectively reduced pain and improved defecation alterations in placebocontrolled trials in IBS patients.Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract.Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients.Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial.Antispasmodics have excellent safety profiles.T-type calcium channel blockers can abolish visceral hypersensitivity in animal models,which makes them potential candidates for the development of novel therapeutic agents in the treatment of IBS. | Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann | 2014 | World Journal of Gastroenterology2014，20，20： | 15 |
| 2 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 3 | Nitric oxide,prostanoids,cyclooxygenase,and angiogenesis in colon and breast cancer显示文摘 | Miyataka M Rich KA | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 4 | A uniform extracellular stimus triggers distinct CAMP signals in different compartmnents of a simple cell显示文摘 | Rich TC Fagan KA Tse TE | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 5 | Cell adhesive motif in region Ⅱ of malarial circumsporozoite protein显示文摘 | Rich KA George FW Law JL | 1990 | Science1990，249，： | 1 |
| 6 | Langerhans cells are not required for the CD8 T cell response to epidermal self- antigens显示文摘 | Bursch LS Rich BE Hogguist KA | 2009 | J Immunol2009，182，8： | 1 |
| 7 | Alterations of the fine structure and androgen secretion of interstitial cells in the experimentally cryptorchid rat testis显示文摘 | Kerr JB Rich KA De Kretser DM | 1979 | Biol Reprod1979，20，3： | 1 |
| 8 | Nitric oxide,prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer显示文摘 | Bins R J Moyataka M Rich KA et M | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 9 | Cytoplasmic bacteria can be targets for autophagy 显示文摘 | Rich KA Burkett C Webster P | 2003 | Cell Microbiol2003，5，7： | 1 |
| 10 | Aberrant expression of c-Fos accompanies photoreceptor cell death in the rd mouse显示文摘 | Zhan Y Blanks JC | 1997 | J Neurobiol1997，32，： | 1 |
| 11 | Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice显示文摘 | Anita Annaházi Krisztina Gecse Marta Dabek Afifa Ait-Belgnaoui András Rosztóczy Richárd Róka Tamás Molnár Vassilia Theodorou Tibor Wittmann Lionel Bueno Helene Eutamene | 2009 | Pain2009，，1： | 1 |
| 12 | Identification of a T-cell epitope on the circumsporozoite protein of Plasmodium vivax 显示文摘 | George FW 4th Law JL Rich KA | 1990 | Infect Immun1990，58，： | 1 |
| 13 | Cytoplasmic bacteria can be targets for autophagy显示文摘 | Rich KA Burkett C Webster P | 2003 | Cell Microbiol2003，5，7： | 1 |
| 14 | Migration and synatogenesis of cone photoreceptors in the developing mouse retina显示文摘 | Rich KA Zhan Y Blanks JC | 1997 | Comp Neurol1997，388，： | 1 |
| 15 | Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbit 显示文摘 | Wong CG Rich KA Liaw LH Hsu HT Berns MW | 2001 | Curr Eye Res2001，22，2： | 1 |
| 16 | Periodontal disease increases the risk of preterm delivery among preeclamptic women显示文摘 | Riche EL Boggess KA Lieff S | 2002 | Ann Periodontol2002，7，： | 1 |
| 17 | Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer显示文摘 | Bing RJ Miyataka M Rich KA | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 18 | Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice显示文摘 | Anita Annaházi Krisztina Gecse Marta Dabek Afifa Ait-Belgnaoui András Rosztóczy Richárd Róka Tamás Molnár Vassilia Theodorou Tibor Wittmann Lionel Bueno Helene Eutamene | 2009 | Pain2009，，1： | 1 |
| 19 | Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbit显示文摘 | Wong CG Rich KA Liaw LH | 2001 | Curr Eye Res2001，22，： | 1 |
| 20 | A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea-Predominant Irritable Bowel Syndrome显示文摘 | Richárd Róka András Rosztóczy Mathilde Leveque Ferenc Izbéki Ferenc Nagy Tamás Molnár János Lonovics Rafael Garcia–Villar Jean Fioramonti Tibor Wittmann Lionel Bueno | 2007 | Clinical Gastroenterology and Hepatology2007，，5： | 1 |
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