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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 3 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 4 | Fixed point theory in symmetric spaces with applications to probabilistic spaces显示文摘 | Hicks T L Rhoades B E | 1999 | Nonl Anal1999，36，3： | 1 |
| 5 | Fixed point theory in symmetric spaces with applications to probabilistic spaces显示文摘 | Hicks T L Rhoades B E | 1993 | Nonlinear Analysis1993，36，： | 1 |
| 6 | Antecedents and Consequences of Burnout in Accounting:Beyond the Role Stress Model 显示文摘 | Fogarty T J Singh C Rhoads R K Moore | 2000 | Behavioral Research in Accounting2000，12，： | 1 |
| 7 | Assessment of Repairable-system Reliability Using Proportional Intensity Model: a Review 显示文摘 | Jiang S T Lande T L Rhoad T R | 2006 | IEEE Transactions on Reliability2006，55，2： | 1 |
| 8 | Antecedents and Consequences of Burnout in Accounting:Beyond the Role Stress Model显示文摘 | Fogarty T J Singh J Rhoads G K | 2000 | Behav Res Account2000，12，： | 1 |
| 9 | Effects of an intense ice storm on the structure of a northern hardwood forest显示文摘 | Rhoads A G Hamburg S P Fahey T J | 2002 | Canadian Journal of Forest Research2002，32，： | 1 |
| 10 | Flow stracture at an asymmetrical stream confluence显示文摘 | RHOADS B L KENWORTHY S T | 1995 | Geomorphplogy1995，11，4： | 1 |
| 11 | TGF-βsignalling-related markers in cancer patients with bone metastases显示文摘 | Baselga J Rothenberg ML Tabernero J Seoane J Daly T Cleverly A Berry B Rhoades SK Ray CA Fill J | | 0，，： | 1 |
| 12 | A Banach type fixed point theorem显示文摘 | Hicks T L Rhoades B E | 1979 | Math Japon1979，24，： | 1 |
| 13 | Diurnal rhythmicity in the transcription of jejunal drug transporters 显示文摘 | Steamd A T Balakrishnan A Rhoads D B | 2008 | J Pharmacol Sci2008，108，1： | 1 |
| 14 | Further studies of coal oxidation显示文摘 | Rhoads C A Senftle J T Coleman M M | | 0，，12： | 1 |
| 15 | Reduction in hydraulic conductivity in relation to clay dispersion and disaggregation显示文摘 | Abu-Sharar T M Bingham F T Rhoades J D | 1987 | Soil Sci SocAmJ1987，51，： | 1 |
| 16 | Common fixed points for four maps in cone metric spaces 显示文摘 | ABBAS M RHOADES B E NAZIR T | 2010 | Appl Math Comput2010，216，1： | 1 |
| 17 | A general principle for Ishikawa iterations for multivalued map- pings显示文摘 | Hu T Huang J C Rhoades B E | 1997 | Indian J Pure Appl Math1997，28，： | 1 |
| 18 | Dissolution of perfluorinated ion containing polymers显示文摘 | T A Rhoades J A Ferguson | 1982 | Anal Chem1982，，54： | 1 |
| 19 | Further studies of coal oxidation显示文摘 | RHOADS C A SENFTLE J T COLEMAN M M | 1983 | Fuel1983，62，12： | 1 |
| 20 | Semiparametric proportional intensity models robusmess for right-censored recurrent failure data显示文摘 | JIANG S T LANDERS T L RHOADS T R | 2005 | Reliability Engineering & System Safety2005，90，1： | 1 |
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