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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 3 | Usefulness of ventricular arrhythmia by biventricular pacing in severe congestive cardiac failture显示文摘 | Walker S Levy MT Rex S | 2000 | AMJ Cardiol2000，86，2： | 1 |
| 4 | Quality in the technical per- formance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the US Multi - Society Task Force on Colorectal Cancer显示文摘 | Rex D K Bond J H Winawer S | 2002 | The American journal of gastro- enterology2002，97，6： | 1 |
| 5 | Criteria for evaluating usability evaluation methods显示文摘 | H Rex Hartson Tcrenee S Andre Robert C Williges | 2003 | International Journal of Human-Computer Interaction2003，15，1： | 1 |
| 6 | Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoictic stem cell transplants: an international consensus显示文摘 | Ascioglu S Rex JH de Panw B | 2002 | Clin Infect Dis2002，34，1： | 1 |
| 7 | Defining opportun-istic invasive fungal infections in immunoeompromised patients with cancer and haematopoietic stem cell transplants: an internatinnal consensus 显示文摘 | Ascioglu S Rex JH de Pauw B | 2002 | Clin Infect Dis2002，34，1： | 1 |
| 8 | Defining opportunistic invasive fungal infections in immunoeompromised patients with cancer and hematopoietie stem cell transplants: an international consensus显示文摘 | Ascioglu S Rex JH de Pauw B | 2002 | Clin Infect Dis2002，34，1： | 1 |
| 9 | Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus显示文摘 | Ascioglu S Rex J H PauwB de | 2002 | Clin Infect Dis2002，34，1： | 1 |
| 10 | Co1orectal Screening and Surveillance: Clinical Guidelines and Rationale Based on New Evidence显示文摘 | Winawer S Fletcher R Rex D | 2003 | Gastroentero12003，124，89： | 1 |
| 11 | Colorectal cancea2 screening and surveillance: clinical guidelines and rationale-update based on new evidence显示文摘 | Winawer S Fletcher R Rex D | 2003 | Gastroenterology2003，124，2： | 1 |
| 12 | Stability analysis of high-order delta-sigma modulation for ADC's显示文摘 | Rex T Baird Terri S Fiez | 1994 | WEE Transitions on Circuits and systemsⅡ:Analog and digital signal processing1994，41，1： | 1 |
| 13 | Wireless caspule endoscopy detects small bowel ulcers in patients with normal results from state of art enteroclysis 显示文摘 | Liangpunsakul S Chadalawada V Rex DK | 2003 | Am J Gastroenterol2003，98，6： | 1 |
| 14 | Defining opportunistic in-vasive fungal infections in immune ocompromised patients with canc-er and hematopoitic stem cell transplants:an international consensus显示文摘 | Ascioglu S Rex JH de Pauw B | 2002 | Clin Infect Dis2002，34，1： | 1 |
| 15 | Behavior and moOehng ot a bolt bearing on a single plate显示文摘 | Rex C O Easterling W S | 2003 | Journal of Structural Engineering ASCE2003，129，6： | 1 |
| 16 | Dynamic preload indicators fail to predict fluid responsiveness in open-chest conditions 显示文摘 | Dewaal E E Rex S Kruitwagen C L | 2009 | Crit Care Med2009，37，2： | 1 |
| 17 | Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants an international consensus 显示文摘 | Ascioglus S Rex JH De Pauw B | 2002 | Clin Infect Dis2002，34，： | 1 |
| 18 | Dynamic preloadindicators fail to predict fluid responsiveness in open -chestconditions显示文摘 | Dewaal EE Rex S Kruitwagen CL | 2009 | Crit Care Med2009，37，2： | 1 |
| 19 | Long-term benefits of biventricular pacing in congestive heart failure:results from the MUltisite STimulation in cardiomyopathy (MUSTIC)study显示文摘 | Leclercq C Rex S | 2002 | J Am Coll Cardiol2002，40，1： | 1 |
| 20 | Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus显示文摘 | Ascioglu S Rex JH de Pauw B | 2002 | Clin Infect Dis2002，34，1： | 1 |
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