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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 5 | Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001显示文摘AIM: To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007. METHODS: Forty consecutive proximal colon polyps ≥ 5 mm in size, removed in 2001, and originally interpreted as hyperplastic polyps by general pathologists at Indiana University, were reviewed in 2007 by 3 GI pathologists. RESULTS: The gastrointestinal (GI) pathologists interpreted 85%, 43% and 30% of the polyps as sessile serrated polyps (sessile serrated adenomas). The overall Kappa was 0.16. When diagnoses were compared in pairs, Kappa values were 0.38 and 0.25 (fair agreement) and 0.14 (slight agreement). CONCLUSION: Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists. | Omer Khalid Sofyan Radaideh Oscar W Cummings Michael J O'Brien John R Goldblum Douglas K Rex | 2009 | World Journal of Gastroenterology2009，15，30： | 3 |
| 6 | Environmental influences on regional deep-sea species diversity显示文摘 | Levin L A Etter R J Rex M A | 2001 | Annual Review of Ecology and Systematics2001，32，： | 1 |
| 7 | Co1orectal Screening and Surveillance: Clinical Guidelines and Rationale Based on New Evidence显示文摘 | Winawer S Fletcher R Rex D | 2003 | Gastroentero12003，124，89： | 1 |
| 8 | The rate of progress and destructiveness of canker stain of planetrees 显示文摘 | WALTER J M Rex E G Schreiber R | 1952 | Phytopathology1952，42，： | 1 |
| 9 | Colorectal cancea2 screening and surveillance: clinical guidelines and rationale-update based on new evidence显示文摘 | Winawer S Fletcher R Rex D | 2003 | Gastroenterology2003，124，2： | 1 |
| 10 | Off-pump myocardial revascularization is associated with less incidence of stroke in elderly patients显示文摘 | Thanos Athanasiou Sharif Al-Ruzzeh Pankaj Kumar Mary-Clare Crossman Mohamed Amrani John R Pepper Rex Del Stanbridge Roberto Casula Brian Glenville | 2004 | The Annals of Thoracic Surgery2004，，2： | 1 |
| 11 | Electron paramoneuc resonance studies of stable free radicals in lignins and humic acide显示文摘 | Rex R W | 1960 | Nature1960，188，4： | 1 |
| 12 | The Aer-O-Scope: Proof of the concept of a pneumatic, skill-independent, self-propelling, self-navigating colonoscope in a pig model显示文摘 | Pfeffer J Grinshpon R Rex D | 2006 | Endoscopy2006，38，2： | 1 |
| 13 | The Relationship of Computer Experience and Computer Self-efficacy to Performance in Introductory Computer Literacy Courses 显示文摘 | Rex K Roth R M | 1998 | Journal of Research on Computing in Education1998，，1： | 1 |
| 14 | Colorectal cancer screening and surveillance: clinical guidelines and rationale-update based on new evidence显示文摘 | Winawer S Fletcher R Rex D | 2003 | Gastroenterology2003，124，： | 1 |
| 15 | Combating antimicrobial resistance: policy recommendations to save lives 显示文摘 | Infectious Diseases Society of America (IDSA) Spellberg B Blaser M Guidos RJ Boucher HW Bradley JS Eisenstein BI Gerding D Lynfield R Relier LB Rex J Schwartz D Septimus E Tenover FC Gilbert DN | 2011 | Clin Infect Dis2011，52，5： | 1 |
| 16 | Formation Damage in Sandstones Causedby Clay Dispersion and Migration 显示文摘 | GRAY H REX R W | 1966 | Clays Clay Minerals1966，15，： | 1 |
| 17 | Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence显示文摘 | Winawer S Fletcher R Rex D | 2003 | Gastroenterology2003，124，2： | 1 |
| 18 | Tourism boosts services industries' employment显示文摘 | Rex T R | 1997 | Arizona Business1997，10，： | 1 |
| 19 | Trained registered nurses/ endoscopy teams can administer propofol safely for endoscopy 显示文摘 | Rex DK Heuss LT Walker JA Qi R | 2005 | Gastroenterology2005，129，6： | 1 |
| 20 | Colorectal cancer screeningand surveillance : clinical guidelines and rationale-Update based onnew evidence显示文摘 | Winawer S Fletcher R Rex D | 2003 | Gastroenterology2003，124，2： | 1 |
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