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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 3 | Captopril: An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure显示文摘 | Brogden Rex N Todd Peter A Sorkin Eugene M | 1988 | Drugs1988，36，5： | 1 |
| 4 | Resistance of Candida species to wfluconazole显示文摘 | Rex J H Rinaldi M G Pfaller M A | 2005 | Agent Chemother2005，49，1： | 1 |
| 5 | Thoracolumbar burst fractures treated with posterior decompression and pedicle screw instrumentation supplemented with balloon-assisted vertebroplasty and calcium phosphate reconstruction显示文摘 | Rex A W Marco Vivek P Kushwaha | 2009 | The Journal of Bone and Joint Surgery2009，91，： | 1 |
| 6 | Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography显示文摘 | REX J H HANSON L H AMANTEA M A | 1991 | Antimicrob Agents Chemother1991，35，： | 1 |
| 7 | Environmental influences on regional deep-sea species diversity显示文摘 | Levin L A Etter R J Rex M A | 2001 | Annual Review of Ecology and Systematics2001，32，： | 1 |
| 8 | American College of Gastroenterology guidelines for colorectal cancer screening 2009显示文摘 | REX D K JOHNSON D A ANDERSON J C | 2009 | Am J Gastroenterol2009，104，3： | 1 |
| 9 | Vascular signal transducerand activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke显示文摘 | Hoffmann C J Harms U Rex A | 2015 | Circulation2015，131，20： | 1 |
| 10 | Quantitative and Qualitative Characteristics of the Stages and Transitions in the Cycle of the Rat Seminiferous Epithelium: Light Microscopic Observations Of Perfusion-Fixed and Plastic-Embedded Testes 显示文摘 | REX A HESS | 1990 | Biology of Reproduction1990，43，： | 1 |
| 11 | Endoplasmic reticulum stress links dyslipidemia to inhibition of proteasome activity and glucose transport by HIV protease inhibitors 显示文摘 | Rex A Parker Oliver P Flint Ruth Mulvey | 2005 | Mol Pharmacol2005，67，6： | 1 |
| 12 | Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse显示文摘 | Wong WT Rex TS Auricchio A | 2004 | Mol Vis2004，10，： | 1 |
| 13 | A fast Divide-and-Conquer Algorithm for Constructing Delaunay Triangulations 显示文摘 | Rex A Dwyer | 1987 | Algorithmica1987，，2： | 1 |
| 14 | Radical hysterectomy and pelvic lymphadenectomy for stage IB2 cervical cancer显示文摘 | Laura J Havrilesky Charles A Leath Warner Huh Brian Calingaert Rex C Bentley John T Soper Angeles Alvarez Secord | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 15 | Impact of bow- el preparation on efficiency and cost of colonoscopy显示文摘 | Rex DK Imperiale TF Latinovich DR et a/ | 2002 | Am J Gastroenterol2002，97，7： | 1 |
| 16 | Pharmacological evaluation of a modified open -field test sensitive to anxiolytic drugs显示文摘 | Rex A Voigt JP Voits M | 1998 | Pharmacol Biochem Be- hav1998，59，3： | 1 |
| 17 | OTT-MAL is a deregulated activator of serum response factor -dependent gene expression 显示文摘 | Descot A Rex Haffner M Courtois G | 2008 | Mol Cell Biol2008，28，20： | 1 |
| 18 | Antifungal susceptibility testing:practical aspects and current challenges显示文摘 | Michael A Pfaller Thomas J Walsh | 2001 | Clinical Microbiology Reviews2001，14，： | 1 |
| 19 | A faster divide-and conquer algorithm for con- structing Delaunay triangulations显示文摘 | Rex A Dwyer | 1987 | Algorithmica1987，2，2： | 1 |
| 20 | Effect of over expression of pigment epithelium derived factor on developing retinal vasculature in the mouse 显示文摘 | Wong WT Rex TS Auricchio A Maguire AM Chung D Tang W | 2004 | Mol Vis2004，10，： | 1 |
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