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| 1 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 2 | The Road to Bioabsorbable Stents: Reaching Clinical Reality?显示文摘 | Paul Erne Matthias Schier Therese J. Resink | 2006 | CardioVascular and Interventional Radiology2006，，1： | 2 |
| 3 | The Web as a Parallel Corpus显示文摘 | Resink P Smith N A | 2003 | Computational Linguistics2003，29，3： | 1 |
| 4 | The road to bioabsorbable stents:Reaching clinical reality?显示文摘 | Erne P Schier M Resink T J | 2006 | Cardiovascular Int Radiology2006，29，1： | 1 |
| 5 | Pimoide modulates the luteinizing hormone-releasing hormone effect on gonadotropin release in the African catfish显示文摘 | De Leeuw R J W Resink E J M Rooyakers | 1985 | Clarias Lazera Gen Comp Endocrinol1985，58，： | 1 |
| 6 | Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye显示文摘 | Hammer J Pache M and Resink T | 2001 | Prog Retin Eye Res2001，20，3： | 1 |
| 7 | BRN2 is a transcrip- tional repressor of CDH13 (T - cadherin) in melanoma cells显示文摘 | Ellmann L Joshi MB Resink TJ | 2012 | Lab Invest2012，92，12： | 1 |
| 8 | Peptide vasoconstrictors, vessel structure, and vascular smooth - muscle proliferation 显示文摘 | HAHN A W RESINK T J KERN F | 1993 | J Cardiovasc Pharmacol1993，22，5： | 1 |
| 9 | Low- and high-density lipoproteins as mitogenic factors for vascular smooth muscle cells: individual,additive and synergistic effects 显示文摘 | Resink T J Bochkov V N Hahn A W | 1995 | J Vasc Res1995，32，5： | 1 |
| 10 | The road to bioabsorbable stems: reaching clinical reality? 显示文摘 | Erne P Schier M Resink TJ | 2006 | Cardiovasc Intervent Radiol2006，29，1： | 1 |
| 11 | Effects of peptide vasocinstrictirs in vessel structure显示文摘 | Resink TJ Mackie E | 1993 | AmJ Med1993，94，： | 1 |
| 12 | Induction of endothelin secretion by angiotensin Ⅱ: Effects on growth and synthetic activity of vascular smooth muscle cells显示文摘 | Scott-Burden T Resink TJ Hahn AWA | 1991 | Cardiovasec Pharmacol1991，17，7： | 1 |
| 13 | Differential susceptibility to neurotoxicity mediated by neurotrophins and neuronal nitric oxide synthase 显示文摘 | Samdani A F Newcamp C Resink A | 1997 | J Neurosci1997，17，12： | 1 |
| 14 | Penetration of liquid urea-formaldehyde adhesive into beech wood显示文摘 | Sernek M Resink J Kamke F A | 1999 | Wood and Fiber Science1999，19，1： | 1 |
| 15 | Platelets and hypertension显示文摘 | Erne P Resink TJ Bürgisser E | 1985 | Journal of cardiovascular pharmacology1985，7，： | 1 |
| 16 | The road to bioabsorbable stents: reaching clinical reality? 显示文摘 | Erne P Schier M Resink T J | 2006 | Cardiovasc Intervent Radiol2006，29，： | 1 |
| 17 | The Road to Bioabsorbable Stents: Reaching Clinical Reality?显示文摘 | Paul Erne Matthias Schier Therese J. Resink | 2006 | CardioVascular and Interventional Radiology2006，，1： | 1 |
| 18 | The road to bioab- sorbable stents: reaching clinical reality? 显示文摘 | Erne Paul Schier Matthias Resink Therese J | 2006 | Cardiovascular and Interventional Radiology2006，29，1： | 1 |
| 19 | Platelet abnormalities and the pathophysiology of essential hypertension显示文摘 | F. R. Bühler T. J. Resink | 1988 | Experientia1988，，2： | 1 |
| 20 | Platelet and hypertension显示文摘 | Erne P Resink TJ Burgisser | 1985 | J Cardiovasc Pharmacol1985，7，6： | 1 |
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