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| 1 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 2 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 3 | Mitigating self-excited flame pulsating and thermoacoustic oscillations using perforated liners显示文摘Open-loop control of self-excited flame pulsating oscillations and thermo-acoustic instability is considered in this work.The performance of the control strategy is numerically evaluated in a 2 D Rij ke-type combustor with a perfo rated pipe implemented.It is found that approximately 38 dB sound pressure level(SPL)reduction can be achieved by actively tuning the cooling flow through the perforated pipe.Furthermore,the vorticity-induced damping performance is contributing to the breaking up of flame-acoustics coupling.However,the shedding of vortices is not uniformly distributed along the perforated pipe.To apply the control strategy in practice and to validate the findings,experimental studies are performed on a customerdesigned Rij ke-type combustor with a perfo rated liner implemented.To mimic practical engines,a cooling flow generated by a centrifugal pump is provided to pass through the perforated pipe.Properly tuning the cooling flow rate is found to lead to the unstable combustor being successfully stabilized.SPL is red uced by approximately 35 dB at ω1/2π≈245 Hz,and harmonic thermoacoustic modes are completely attenuating.Further study is conducted by suddenly re moving the perforated pipe section.The combustion system is found to be associated with not only classical thermo-acoustic limit cycle oscillations with a dominant mode at 2.45 × 102 Hz,but also beating oscillations at 1.4 × 1 00 Hz.It is revealed that increasing acoustic losses by implementing the perforated pipe is another critical mechanism contributing to attenuating flame pulsating instability.The present work opens up an applicable means to attenuate both selfexcited high-frequency thermoacoustic and low-frequency flame pulsating oscillations. | Dan Zhao Ephraim Gutmark Arne Reinecke | 2019 | Science Bulletin2019，64，13： | 3 |
| 4 | Effects of endothelin ET_A receptor blocker LU 135252 on cardiac remod-eling and survival in a hypertensive rat model of chronic heart failure显示文摘瞄准:调查 endothelin 希腊语字母的第七字受体阻滞物是否在在长期的心力衰竭(CHF ) 的一个高血压的老鼠模型的心脏的改变和幸存上提供类似的利益。方法:男性击容易自发地, hypertensive (SHR-SP ) 老鼠受到左冠的动脉的永久结扎并且与 endothelin 希腊语字母的第七字受体阻滞物 LU 135252 被对待 6 个星期(30 mg.kg (在结扎或 untreatment 以后开始 24 h 的 -1).d(-1)) 。假冒操作老鼠用作正常控制。吝啬的动脉的血压(地图),心搏率( HR ),左室的结束心脏舒张的压力( LVEDP ),左室的收缩性( LV dp/dt (最大)),左室的内部直径( LVD )和圆周( LVC ),氏族的厚度,左室的空隙的骨胶原内容(国际计算中心)和心重量( HW )在处理的结束被测量。结果:与未经治疗的组相比, LU 135252 趋于增加 HW (1.43 +/-0.03 对 1.38 +/-0.04 g;P> 0.05 ) ,增加的 LVD (7.65+/-0.24 公里对 6.58+/-0.14 公里;P<0.05 ) ,显著地增加的 LVC (30.11+/-0.83 公里对 24.82+/-0.85 公里;P< 0.01 ) 并且减少的左室的国际计算中心(3.79%+/-0.09% 对 6.71%+/-0.11% ;P< 0.01 ) ,稍微降低的地图(132+/-6 毫米汞柱对 142+/-4 毫米汞柱;P>0.05 ) ,减少的 LVEDP (14 4 毫米汞柱对 27+/-4 毫米汞柱;P<0.05 ) 并且改进 LV dp/dtmax (4230+/-450 mmHg/s 对 1950+/-400 mmHg/s;P<0.05 ) ;幸存没显著地被延长(13% 对 11% ;P=NS ) 。结论:在 CHF 的这个高血压的老鼠模型,然而,有 LU 135252 的长期的 endothelin 希腊语字母的第七字受体封锁改进心脏的血液动力学它不影响长期的幸存并且变得更坏心脏的改变。因此, endothelin 希腊语字母的第七字受体对手是不大可能的与 CHF 在病人的管理有一个重要角色。 | Qin-gui XIA Alexander REINECKE Marc DORENKAMP Mat Jap DAEMEN Reichiger SIMON Thomas UNGER | 2006 | Acta Pharmacologica Sinica2006，27，11： | 3 |
| 5 | Pectin May Hinder the Unfolding of Xyloglucan Chains during Cell Deformation: Implications of the Mechanical Performance of Arabidopsis Hypocotyls with Pectin Alterations显示文摘种房间墙,象大量的其它一样生物材料,是自然增强纤维的合成材料。他们的机械性质自己高度依赖于生硬含纤维的阶段和软矩阵阶段的相互影响并且在矩阵变丑上。用特定的 Arabidopsis thaliana 异种,我们与改变的 xyloglucan 和果胶作文在胚轴的主要房间墙中学习了矩阵集会的机械角色。标准 microtensile 测试和周期的装载协议象少些展出 50% 的 qua2 一样与影响 RGII 硼酸盐 diester 交叉结合和妨碍的 xyloglucan fucosylation 在 mur1 胚轴上被执行 homogalacturonan 与相比野类型。作为控制,野类型的植物(Col-0 ) 和在果胶网络展出特定的 xyloglucan fucosylation 和没有差别的 mur2 被利用。在标准张力的测试,有果胶改变的异种的胚轴的最终的压力层次(张力的力量)(mur1, qua2 ) 是相当未受影响的,而他们的张力的僵硬显著地与 Col-0 相比被减少。周期的装载测试显示了一在首先拉紧然而,其度为 mur1 和 qua2 胚轴是高得多的期间在第一个周期和塑料变丑以后所有胚轴使硬。基于机械数据和当前的房间墙模型,在纤维素纤丝之间的合拢的 xyloglucan 链可以趋于在胚轴拉紧期间展开,这被假定。这回答被几何限制可能由于果胶刚硬妨碍。 | Willie Abasolo Michaela Eder Kazuchika Yamauchi Nicolai Obel Antje Reinecke Lutz Neumetzler John W.C. Dunlop Gregory Mouille Markus Pauly Herman Hofte Ingo Burgert | 2009 | Molecular Plant2009，2，5： | 2 |
| 6 | Use of paclitaxel-eluting balloons for endotherapy of anastomotic strictures following liver transplantation显示文摘 | I. Kabar V. Cicinnati S. Beckebaum S. Cordesmeyer Y. Avsar H. Reinecke H. Schmidt | 2012 | Endoscopy2012，，12： | 2 |
| 7 | Survival, integration and differentiation of cardiomyocyte grafts a study in normal and injured rat hearts显示文摘 | Reinecke H Zhang M Bartosek T | 1999 | Circulation1999，100，2： | 2 |
| 8 | Trilateral interaction between innervation,leukocyte,and adventitia:a new driver of atherosclerotic plaque formation显示文摘A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic strategy.Atherosclerosis continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or stroke.The disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood pressure.Beyond such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation. | Yahya Sohrabi Holger Reinecke Oliver Soehnlein | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 2 |
| 9 | Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts 显示文摘 | Murry CE Soonpaa MH Reinecke H | 2004 | Nature2004，428，： | 1 |
| 10 | Inhibitors of HIV-1 replication that inhibit HIV integrase显示文摘 | Robinson WE Reinecke MG Abdel-Malek S | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 11 | Effects of induced fatigue on brain activity during sensorimotor control显示文摘 | Baumeister J Reinecke K Schubert M | 2012 | Eur J Appl Physiol2012，112，7： | 1 |
| 12 | Shear database for reinforced concrete members without shear reinforcement显示文摘 | REINECK K H KUCHMA D A KIM K S | 2003 | ACI Structural Journal2003，100，2： | 1 |
| 13 | Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts显示文摘 | Murry CE Soonpaa MH Reinecke H | 2004 | Nature2004，428，6983： | 1 |
| 14 | An experimental evaluation of the influence of temperature on the natural rate of increase of Daphnia pulex De Geer 显示文摘 | Van As J G Combrinck C Reinecke A J | 1980 | J Limnol Soc Southern Africa1980，6，： | 1 |
| 15 | Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral arteries显示文摘 | Erren M Reinecke H Junker R | 1999 | Arterioscler Thromb Vasc Biol1999，19，13： | 1 |
| 16 | Recent developments and industrial research applications of capacitance tomography显示文摘 | Reinecke N Mewes D | 1996 | Meas Sci Technol1996，7，3： | 1 |
| 17 | Recommendations for statin therapy in the elderly 显示文摘 | Dfiser S Marz W Reinecke MF | 2004 | Internist (Berl)2004，45，9： | 1 |
| 18 | Ferritin overexpression for noninvasive magnetic resonance imaging-based tracking of stem cells transplanted into the heart 显示文摘 | Naumova AV Reinecke H Yarnykh V | 2010 | Mol Imaging2010，9，： | 1 |
| 19 | Moisture prefer- ences,growth and reproduction of the compost worm Eis- enia foetida (Oligochaeta)显示文摘 | REINECKE A J VENTER J M | 1987 | Biol Fert Soil1987，，3： | 1 |
| 20 | Moisture requirements in the life cycle of Perionyx excavatus (Oligochaeta)显示文摘 | LYNETTE H VILJOEN S A REINECKE A J | 1992 | Soil Biology and Biochemistry1992，24，12： | 1 |
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