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| 1 | Immunomodulatory properties of dental tissue-derived mesenchymal stem cells: Implication in disease and tissue regeneration显示文摘Mesenchymal stem cells(MSCs)are considered as an attractive tool for tissue regeneration and possess a strong immunomodulatory ability.Dental tissuederived MSCs can be isolated from different sources,such as the dental pulp,periodontal ligament,deciduous teeth,apical papilla,dental follicles and gingiva.According to numerous in vitro studies,the effect of dental MSCs on immune cells might depend on several factors,such as the experimental setting,MSC tissue source and type of immune cell preparation.Most studies have shown that the immunomodulatory activity of dental MSCs is strongly upregulated by activated immune cells.MSCs exert mostly immunosuppressive effects,leading to the dampening of immune cell activation.Thus,the reciprocal interaction between dental MSCs and immune cells represents an elegant mechanism that potentially contributes to tissue homeostasis and inflammatory disease progression.Although the immunomodulatory potential of dental MSCs has been extensively investigated in vitro,its role in vivo remains obscure.A few studies have reported that the MSCs isolated from inflamed dental tissues have a compromised immunomodulatory ability.Moreover,the expression of some immunomodulatory proteins is enhanced in periodontal disease and even shows some correlation with disease severity.MSC-based immunomodulation may play an essential role in the regeneration of different dental tissues.Therefore,immunomodulation-based strategies may be a very promising tool in regenerative dentistry. | Oleh Andrukhov Christian Behm Alice Blufstein Xiaohui Rausch-Fan | 2019 | World Journal of Stem Cells2019，11，9： | 21 |
| 2 | 国外老年人皮肤干燥评估与干预的研究进展显示文摘皮肤干燥是指皮肤因水分或脂质缺乏而产生的紧绷、脱屑、瘙痒等一系列症状,是老年人最常见的皮肤问题。皮肤干燥不仅可引起皮肤瘙痒、鱼鳞症等皮肤病,还可降低老年人的舒适度,增加感染概率,减缓创面愈合速度,严重降低老年人的生活质量。 | 戴付敏 王丽君 Christine Behm 陈瑞云 张娜 石贞玉 | 2017 | 中华护理杂志2017，52，1： | 15 |
| 3 | 国际老年长期照护保险实施现状及启示显示文摘随着经济发展,医疗卫生服务条件的改善,人口预期寿命增加,家庭规模缩小及人口老龄化,我国老年人的长期照护问题日益凸显[1,2]。长期照护保险指对因年老、慢性疾病、意外伤害等原因导致身体功能部分或全部丧失,生活无法自理,需要接受长期康复和护理的被保险人,在接受他人护理时对其支付的费用给予补偿的一种健康保险[3]。我国老年人长期照护占据了大量的医疗保险支出,但相关养老保险、医疗保险制度尚处于探索阶段[4,5]。 | 陈瑞云 戴付敏 Christine Behm 王靓 郭津津 | 2017 | 中国老年学杂志2017，37，12： | 7 |
| 4 | 农村建设理论与实践——以德国为例显示文摘基于德国农村建设保护和设计的理论研究成果,系统分析了德国现代农村建设内涵、依据、标准与现代农村建设理论,以及当前在中国城镇化下农村建设中遇到的问题与挑战,并讨论了中国未来新农村建设的发展趋势。期以德国较为成熟的理念、方法和实践经验为我国新农村建设理论发展与实践应用提供科学参考与技术依据。 | 谢辉 余天虹 李亨 Holger Behm Alexander Schmidt | 2015 | 城市发展研究2015，22，4： | 4 |
| 5 | 生命科学用原子力显微镜之原理与应用显示文摘本文在简单介绍原子力显微镜(AFM)成像原理及其特点的基础上,主要从AFM对核酸、蛋白质和细胞微生物的表面特性、内部结构、分子细胞间的相互作用及其动态观察、单分子操纵以及分子识别等方面的应用加以举例介绍。随着科学技术的发展,AFM的不断改进与完善,AFM必将成为生命科学研究的重要手段之一。 | 黄俊逸 徐新颜 Gerd Behme | 2007 | 自然杂志2007，29，5： | 3 |
| 6 | Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness显示文摘AIM:To study the safety and effectiveness associated with accelerated infliximab infusion protocols in patients with inflammatory bowel disease(IBD).METHODS:Original protocols and infusion rates were developed for the administration of infliximab over 90-min and 60-min.Then the IBD patients on stable maintenance infliximab therapy were offered accelerated infusions.To be eligible for the study,patients needed a minimum of four prior infusions.An initial infusion of 90-min was given to each patient;those tolerating the accelerated infusion were transitioned to a 60-min infusion protocol at their next and all subsequent visits.Any patient having significant infusion reactions would be reverted to the standard 120-min protocol.A change in a patient's dose mandated a single 120-min infusion before accelerated infusions could be administered again.RESULTS:The University of Virginia Medical Center's Institutional Review Board approved this study.Fifty IBD patients treated with infliximab 5mg/kg,7.5mg/kg and 10mg/kg were offered accelerated infusions.Forty-six patients consented to participate in the study.Nineteen(41.3%) were female,five(10.9%) were African American and nine(19.6%) had ulcerative colitis.The mean age was 42.6 years old.Patients under age 18 were excluded.Ten patients used immunosuppressive drugs concurrently out of which six were taking azathioprine,three were taking 6-mercaptopurine and one was taking methotrexate.One of the 46 study patients used corticosteroid therapy for his IBD.Seventeen of the patients used prophylactic medications prior to receiving infusions;six patients received corticosteroids as pre-medication.Four patients had a history of distant transfusion reactions to infliximab.These reactions included shortness of breath,chest tightness,flushing,pruritus and urticaria.These patients all took prophylactic medications before receiving infusions.46 patients(27 males and 19 females) received a total of fifty 90-min infusions and ninety-three 60-min infusions.No infusion reactions were reported.There were no adverse events,including drug-related infections.None of the patients developed cancer of any type during the study timeframe.Total cost savings for administration of the both 90-min and 60-min accelerated infusions compared to standard 120-min infusions was estimated to be $53 632($116 965 vs $63 333,P=0.001).One hundred and eighteen hours were saved in the administration of the accelerated infusions(17 160 min vs 10 080 min,P=0.001).In the study population,overweight females [body mass index(BMI)>25.00kg/m2] were found to have statistically higher BMIs than overweight males(mean BMI 35.07±2.66kg/m2 vs 30.08±0.99kg/m2,P=0.05),finding which is of significance since obesity was described as being one of the risk factors for Crohn's disease.CONCLUSION:We are the first US group to report substantial cost savings,increased safety and patient satisfaction associated with accelerated infliximab infusion. | John McConnell Simona Parvulescu-Codrea Brian Behm Beth Hill Elizabeth Dunkle Karen Finke Kathryn Snyder Anne Tuskey Debbie Cox Beth Woodward | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，5： | 2 |
| 7 | Urotensin II differentially regulates macrophage and hepatic cholesterol homeostasis显示文摘 | Robert S. Kiss Zhipeng You Jacques Genest David J. Behm Adel Giaid | 2011 | Peptides2011，，5： | 2 |
| 8 | 绿色屋顶设计建议显示文摘由于环境效益和能够获得绿色建筑荣誉证书,绿色屋顶在美国越来越普及。政府从税收方面还出台了鼓励采用绿色屋顶的政策,并且政府的建筑都要求采用绿色屋顶。实践证明,绿色屋顶确实能提高环境效益,能有效地减少以下危害:1)空气污染;2)建筑能耗;3)从屋面流失的雨水;城市热岛效应。 | 褚成斌 Michael Behm | 2012 | 工程质量2012，30，2： | 2 |
| 9 | Cellular and molecular imaging with targeted contrast ultrasound显示文摘 | Behm C Lindner J | 2006 | Ultrasound Quarterly2006，22，1： | 1 |
| 10 | SundwardInterventional radiology techniques for the diagnosis of lymphoma or leukemia显示文摘 | Garrett KM Hoffer FA Behm FG | 2001 | Cytopathology2001，12，3： | 1 |
| 11 | Differentiation-independent retinoid induction of folate receptor type beta,a potential tumor target in myeloid leukemia显示文摘 | Wang H Zheng X Behm FG | 2000 | Blood2000，96，3： | 1 |
| 12 | Formic acid oxidation on pure and Bi-modified Pt( 111): temper-ature effects 显示文摘 | Schmidt T J Behm R J Grgur B N Markovic N M Ross P N | 2000 | Langmuir2000，16，21： | 1 |
| 13 | Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia显示文摘 | Jeha S Behm F Pei D | 2006 | Blood2006，108，10： | 1 |
| 14 | Cranioplasty after decompressive hemicraniectomy:Underestimated surgery-associated complications显示文摘 | Doro thee Watcher Kim Rein eke Timor Behm | | 0，，： | 1 |
| 15 | Mesoporous Au/TiO 2 Catalysts for Low Temperature CO Oxidation显示文摘 | Y. Denkwitz J. Geserick U. H?rmann V. Plzak U. Kaiser N. Hüsing R. J. Behm | 2007 | Catalysis Letters2007，，3： | 1 |
| 16 | Novel Rho Kinase inhibitors with anti-inflammatory and vasodilatory activities显示文摘 | Doe C Bentley R Behm DJ | 2007 | J Pharmacol Exp Ther2007，320，1： | 1 |
| 17 | Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities 显示文摘 | Doe C Beatley R Behm D J | 2007 | J Pharmacol Exp % her2007，320，1： | 1 |
| 18 | Trunk muscle activity increases with unstable squat movements 显示文摘 | Anderson K Behm DG | 2005 | Can J Appl Physiol2005，30，1： | 1 |
| 19 | Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities 显示文摘 | Doe C Bentley R Behm DJ | 2007 | J Pharmacol Exp Ther2007，320，1： | 1 |
| 20 | The enigmatic eosinophil: investigation of the biological role of eosinophils in parasitic helminth infection显示文摘 | Ovington KS Behm CA | 1997 | Mere Inst Oswaldo Cruz1997，92，2： | 1 |
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