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| 1 | Evaluation of fully covered self-expanding metal stents in benign biliary strictures and bile leaks显示文摘AIM: To investigate the use of fully covered metal stents in benign biliary strictures (BBS) and bile leaks. METHODS: We studied 17 patients, at Harbor-UCLA Medical center (Los Angeles), with BBS (n=12) and bile leaks (n=5) from July 2007 to February 2012 that had received placement of fully covered self-expanding metal stents (FCSEMs). Fourteen patients had endoscopic placement of VIABIL (Conmed, Utica, New York, United States) stents and three had Wallflex (Boston Scientific, Mass) stents. FCSEMS were 8 mm or 10 mm in diameter and 4 cm to 10 cm in length. Patients were followed at regular intervals to evaluate for symptoms and liver function tests. FCSEMS were removed after 4 or more weeks. Resolution of BBS and leak was documented cholangiographically following stent removal. Stent patency can be defined as adequate bile and contrast flow from the stent and into the ampulla during endoscopic retrograde cholangiopancreatography (ERCP) without clinical signs and/or symptoms of biliary obstruction. Criterion for bile leak resolution at ERCP is defined as absence of contrast extravasation from the common bile duct, cystic duct remanent, or gall blad-der fossa. Rate of complications such as migration, and instent occlusion were recorded. Failure of endoscopic therapy was defined as persistent biliary stenosis or continuous biliary leakage after 12 mo of stent placement. RESULTS: All 17 patients underwent successful FC- SEMS placement and removal. Etiologies of BBS included: cholecystectomies (n=8), cholelithiasis (n=2), hepatic artery compression (n=1), pancreatitis (n=2), and Whipple procedure (n=1). All bile leaks occurred following cholecystectomy. The anatomic location of BBS varied: distal common bile duct (n=7), common hepatic duct (n=1), hepaticojejunal anastomosis (n=2), right intrahepatic duct (n=1), and choledochoduo-denal anastomatic junction (n=1). All bile leaks were found to be at the cystic duct. Twelve of 17 patients had failed prior stent placement or exchange. Resolution of the biliary strictures and bile leaks was achieved in 16 of 17 patients (94%). The overall median stent time was 63 d (range 27-251 d). The median stent time for the BBS group and bile leak group was 62 ± 58 d (range 27-199 d) and 92 ± 81 d (range 48-251 d), respectively. All 17 patients underwent successful FCSEMS removal. Long term follow-up was obtained for a median of 575 d (range 28-1435 d). Complications occurred in 5 of 17 patients (29%) and included: migration (n=2), stent clogging (n=1), cholangitis (n=1), and sepsis with hepatic abscess (n=1). CONCLUSION: Placement of fully covered self-expanding metal stents may be used in the management of benign biliary strictures and bile leaks with a low rate of complications. | David Lalezari Inder Singh Sofiya Reicher Viktor Ernst Eysselein | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 8 |
| 2 | Acute liver injury induced by weight-loss herbal supplements显示文摘We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients dem onstrated f indings consistent with drug-induced acute liver injury. To our knowledge, we are the fi rst instit ute to report acute liver injury from both of these two typ es of weight-loss herbal supplements together as a case series. The series emphasizes the importance of taking a cautious approach when consuming herbal supp lements for the purpose of weight loss. | Gary C Chen Vivek S Ramanathan David Law Pauline Funchain George C Chen Samuel French Boris Shlopov Viktor Eysselein David Chung Sonya Reicher Binh V Pham | 2010 | World Journal of Hepatology2010，2，11： | 5 |
| 3 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 4 | Linear mannan in the endosperm of Schizolobium amazonicum 显示文摘 | Petkowicz CL0 Reicher F Chanzy H | 2001 | Caebohydr Polym2001，44，： | 1 |
| 5 | Simultaneous 'hy- brid' percutaneous coronary intervention andminimally in-vasive surgical bypass grafting: feasi - bility, safety, and clinical outcomes 显示文摘 | Reicher B Poston RS Mehra MR | 2008 | Am Heart J2008，155，4： | 1 |
| 6 | Hos Pictal aequirsd men ingitisin Pat ients undergo ingeraniotony incidence,evolution and risk factors显示文摘 | Reicher MC Medeirous EA Ferraz FA | 2002 | Am J Infect con trol2002，30，3： | 1 |
| 7 | Isolation of a lectin and a galactoxyloglucan from Mucuna sloanei seeds显示文摘 | DANIELE M A TEIXEIRA-S(A) FANY REICHER BRAGA RENATA C | 2009 | Phytochemistry2009，70，1718： | 1 |
| 8 | On the etiology of climates显示文摘 | SCHNEIDER B REICHERS A E | | 0，，01： | 1 |
| 9 | Overall Job Satisfaction:How Good Are Single-item Measures?显示文摘 | REICHERS A E HUDY M J | 1997 | Journal of Applied Psychology1997，82，2： | 1 |
| 10 | An Interactionist Perspective on Newcomer and Organizational Socialization Rates显示文摘 | Reichers A E | | 0，，02： | 1 |
| 11 | On the Etiology of Climates 显示文摘 | Schneider B Reichers A E | 1983 | Ames Personnel Psyhology1983，36，1： | 1 |
| 12 | The role of tree leaf mulch and nitrogen fertilizer on turfgrass soil quality显示文摘 | V. Acosta-Martínez Z. Reicher M. Bischoff R. F. Turco | 1999 | Biology and Fertility of Soils1999，，： | 1 |
| 13 | Circadian variation in pain onset in unstable angina pectoris显示文摘 | Behar S Reicher H Goldbourt U | 1991 | Am J Cardiol1991，61，1： | 1 |
| 14 | Understanding and Managing Cynicism about Organizational Change显示文摘 | Reichers A E Wanous J P Austin J T | 1997 | The Academy of Management Executive1997，11，1： | 1 |
| 15 | Magnetic resonance imaging in the early diagnosis of ischemic necrosis of the formoral head显示文摘 | Richard H Gold Murray Reicher | 1987 | Clin Orthop1987，214，： | 1 |
| 16 | Simultaneous 'hybrid' percutaneous coronary intervention and minimally invasive surgical bypass grafting:feasibility,safety,and clinical outcomes显示文摘 | Reicher B Poston RS Mehra MR | | 0，，： | 1 |
| 17 | Demand dispatch显示文摘 | BROOKS A LU E REICHER D | 2010 | IEEE Power and Energy Magazine2010，8，3： | 1 |
| 18 | Meniscal injuries: detection using MR imaging 显示文摘 | Reicher MA Hartzman S Duckweiler GR | 1986 | Radiology1986，159，3： | 1 |
| 19 | The role of treeleaf mulch and nitrogen fertilizer on turf grass soil quality 显示文摘 | Acosta-Martinez V Reicher Z Bischoff M | 1999 | Biological Fertile Soils1999，29，： | 1 |
| 20 | Circadian in pain onset inunsable angina pectoris显示文摘 | BEHAR S REICHER H GOLDBOURT U | 1991 | Am J Cardiol1991，67，： | 1 |
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