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| 1 | Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis显示文摘AIM To determine the effect of overexpression of fibrinogenlike protein 2(FGL2) on regulatory T cell(Treg) and effector T(Teff) cell function on T cell-induced colitis in Rag1-/-mice.METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2 Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/-mice. RESULTS In vitro, fgl2 Tg Treg had enhanced immunosuppressive activity, and fgl2 Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice(fgl2+/+) into Rag1-/-mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2 Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/-Treg were only partially protective. In mice that received fgl2 Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2 Tg mice did not produce colitis. CONCLUSION Here we show that fgl2 Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2 Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease. | Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy | 2017 | World Journal of Gastroenterology2017，23，15： | 2 |
| 2 | Determination of cyclosporine in saliva using liquid chromatography 3/tandem mass spectrometry显示文摘 | AN ISH IM REGINALD G FATEMEH A | 2004 | Ther Drug Monit2004，26，： | 1 |
| 3 | Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites 显示文摘 | Stephan A Karl A Reginald F | 2003 | Clin Pharmacol Ther2003，73，1： | 1 |
| 4 | Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions显示文摘 | Bobryshev YV Reginald S Lord A | 1998 | Cardiovasc Res1998，37，3： | 1 |
| 5 | Composting and phytoremediation treatment of petro- leum sludge 显示文摘 | Ayotamuno Josiah M Kogbara Reginald B Agele Eriye A | 2010 | Soil Sediment Contain2010，19，6： | 1 |
| 6 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
| 7 | Mapping of vascular dendritic cells in atherosclerotic artrise suggests their involvement in local immune-inflammatory reactions显示文摘 | Bobryshev YV Reginald S Lord A | 1998 | Cardiovasc Res1998，37，3： | 1 |
| 8 | Intraocular lens implantation in the absence of capsular support显示文摘 | Michael D Wagoner Terry A Cox Reginald George Ariyasu Deborah S Jacobs Carol L Karp | 2003 | Ophthalmology2003，，4： | 1 |
| 9 | Diagnosis,treatment and follow up of women undergoing conscious pain mapping for chronic pelvic pain:a prospective cohort study显示文摘 | Swanton A Iyer L Reginald PW | 2006 | BJOG2006，113，7： | 1 |
| 10 | Biostimulation supplemented with phytoremediation in the reclamation of a petroleum contaminated soil显示文摘 | Josiah M A Reginald B K Onozemini S A | 2009 | World J Mierobiol Biotechnol2009，25，： | 1 |
| 11 | Scleral explant removal: the last decade 显示文摘 | Deokule S Reginald A Callear A | 2005 | Eye2005，17，6： | 1 |
| 12 | S-100 positive cells in human arterial intima and in atherosclerotic lesion显示文摘 | Bobryshev YV Reginald S Lord A | 1995 | Cardiovas Res1995，29，5： | 1 |
| 13 | A resource-based-view of the socially responsible firm:stakeholder interdependence,ethical awareness,and issue responsiveness as strategic assets显示文摘 | Litz Reginald A | 1996 | Journal of Business Ethic1996，15，12： | 1 |
| 14 | Determinants of Innovative Behavior:A Path Model of Individual Innovation in the Workplace 显示文摘 | Susanne G Scott Reginald A Bruce | 1994 | Academy of Management Journal1994，37，3： | 1 |
| 15 | The red wine polyphenol, resveratrol, exerts acute direct actions on guinea-pig ventricular myocytes 显示文摘 | REGINALD L Mark A S KENNETH T M | 2005 | Eur J Pharmacol2005，519，12： | 1 |
| 16 | Formation of ultrafinegrained magnetite in soils显示文摘 | Maher Barbara A Taylor Reginald M | 1988 | Nature1988，336，： | 1 |
| 17 | Determinants of in novative behavior: A path model of individual innovation in the workplaee显示文摘 | Scott Susanne G Bruce Reginald A | 1994 | Academy of Management Journal1994，37，3： | 1 |
| 18 | Semi-automatic object-based video segmentation with labeling of color segments显示文摘 | Ioannis Patras Emile A Hendriks Reginald L Lagendijk | 2003 | Signal Processing:Image Communication2003，18，： | 1 |
| 19 | The red wine polyphenol, resveratrol, exerts acute direct actions on guinea-pig ventricular myocytes显示文摘 | REGINALD L MARK A S KENNETH T M | 2005 | Eur J Pharmacol2005，519，： | 1 |
| 20 | Semi-automatic object-based video segmentation with labeling of color segments显示文摘 | Ioannis Patrasa Emile A Hendriks Reginald L Lagendijk | 2003 | Image Communication2003，18，： | 1 |
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