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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter Pylori 显示文摘 | Mehmet N Refik M Harpuluoglu M | 2004 | New Microbiol2004，27，2： | 1 |
| 3 | Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter pylori显示文摘 | Mehmet N Refik M Harputluoglu M | 2004 | New Microbiol2004，27，2： | 1 |
| 4 | The effect of the timing of hip fracture surgery on the activity of daily living and mortality in elderly archives of gerontology显示文摘 | Hüseyin DM Refik M Cemil Y | 2004 | Geriatrics2004，39，： | 1 |
| 5 | Confidentiality and integrity for data aggregation in WSN using peer monitoring显示文摘 | ROBERTO D P PIETRO M REFIK M | 2009 | Security and Communication Networks2009，2，2： | 1 |
| 6 | Sol- id-phase extraction of silver in geological samples and its determination by FAAS显示文摘 | REFIKER H S MERDIVAN M AYGUN R S | 2008 | Separation Science and Technology2008，43，1： | 1 |
| 7 | Internet security architecture 显示文摘 | REFIK M | 1999 | Computer Nerworks1999，，31： | 1 |
| 8 | PRISM--Privacy-preserving search in MapReduce显示文摘 | Blass W O Pietro R D Refik M | 2012 | Privacy Enhancing Technologies2012，7384，： | 1 |
| 9 | Cytokine profile and nitric oxide levels in sera from patients weth brucellosis 显示文摘 | Refik M Mehmet N Durmaz R | 2004 | Braz J Med Biol Res2004，37，11： | 1 |
| 10 | Confidentiality and integrity for data aggregation in WSN using peer monitoring显示文摘 | ROBERTO D P PIETRO M REFIK M | 2009 | Security and Communication Networks2009，2，2： | 1 |
| 11 | Serum adenosine deaminase and cytidine activities in patients with systemic lupus erythematosus 显示文摘 | Seyithan Taysi M Fevzi Ploat Refik All Sari | 2002 | Clin Chem Lab Med2002，40，5： | 1 |
| 12 | 1Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter Pylori显示文摘 | Mehmet N Refik M Harpuluoglu M | 2004 | 1 NewMicrobiol2004，27，2： | 1 |
| 13 | The effect of the timing of hip fracture surgery on the activity of daily living and mortality in elderly显示文摘 | Huseyin D M Refik Mas Cemil Y | | 0，，： | 1 |
| 14 | The effect of taurine treatment on oxi-dative stress in experimental liver fibrosis 显示文摘 | Refik M Comert B Oncu K | 2004 | Hepatol Res2004，28，4： | 1 |
| 15 | The effect of antibiotec and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis显示文摘 | Sedat AM Refik M Bilgin C | 2003 | Pancreas2003，26，4： | 1 |
| 16 | Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter Pylori显示文摘 | Mehmet N Refik M Harpuluoglu M | 2004 | New Microbiol2004，27，2： | 1 |
| 17 | Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter pylori显示文摘 | Mehmet N Refik M Harputluoglu M | 2004 | New Microbiol2004，27，2： | 1 |
| 18 | Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter pylori显示文摘 | Mehmet N Refik M Harputluoglu M | 2004 | New Microbiol2004，27，2： | 1 |
| 19 | Sefebook: a privacy- preserving online social network leveraging on real-life trust 显示文摘 | Leucio A C Refik M Thorsten S | 2009 | IEEE Communications Magazine2009，47，12： | 1 |
| 20 | The effect of taurine treatment on oxidative stress in ex perimental liver fibrosis显示文摘 | Refik Mas M Comert B Oncu K Vural S A Akay C Tasci I et ai | 2004 | Hepatol Res2004，28，： | 1 |
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