|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 2 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 3 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 4 | Synthesis of unsaturated polyester resins based on rosin acrylic acid adduct for coating applications显示文摘 | Ayman M Atta Ashraf M Elsaeed Reem K Farag | 2007 | Reactive and Functional Polymers2007，67，： | 1 |
| 5 | Synthesis of unsaturated polyester resins based on rosin acrylic acid adduct for coating applications 显示文摘 | Ayman M Atta Ashraf M Elsaeed Reem K Farag | 2007 | Reactive & Functional Polymers2007，，67： | 1 |
| 6 | Central venous pressure:principles,measurement,and interpretation显示文摘 | Reems MM Aumann M | | 0，，1： | 1 |
| 7 | Central venous pressure : principles, measurement,and interpretation显示文摘 | Reems MM Auman M | 2012 | Compend Contin Educ Vet2012，34，1： | 1 |
| 8 | Crosslinked cinnamoyloxyethyl methacrylate and isooctyl acrylate copolymers as oil sorbers显示文摘 | Atta Ayman M El-Ghazawy Rasha A M Farag Reem K | | 0，，07： | 1 |
| 9 | Demulsifier systems applied to breakdown petroleum sludge 显示文摘 | Abdel-Azim A Abdel Azim Abdul-Raheim M Abdul-Raheim Reem K Kamel | 2011 | Journal of Petroleum Science and Engi- neering2011，78，： | 1 |
| 10 | 显示文摘 | Ayman M A Rasha A E G Reem K F | 2005 | Polym Int2005，54，： | 1 |
| 11 | 显示文摘 | Ayman M A Rasha A E G Reem K F | 2006 | React Funct Polym2006，66，： | 1 |
| 12 | New vinyl ester resins based on rosin for coating 显示文摘 | Ayman M A Shymaa M E Reem K F | 2006 | Applications Reactive & Functional Polymers2006，66，12： | 1 |
| 13 | Synthesis of unsaturated polyester resins based on rosin acrylic acid adduct for coating applications显示文摘 | Ayman M A Shymaa M E Reem K F | 2007 | Reactive and Functional Polymers2007，67，6： | 1 |
| 14 | Benzo(a)pyrene,3-methylcholanthrene and β-naphthoflavone induce oxidative stress in hepatoma hepa1c1c7 cells by an AHR-dependent pathway显示文摘 | REEM H ELBEK A I HESHAM M | 2004 | Free Radical Res2004，38，11： | 1 |
| 15 | Central Venous Pressure: Principles, Measurement, and Interpretation显示文摘 | Reems M M Aumann M | 2012 | Compend Contin Educ Vet2012，34，1： | 1 |
| 16 | New vinyl ester resins based on rosin for coating applications显示文摘 | Ayman M Atta Shymaa M E1-Saeed Reem K Farag | 2006 | React Funct Polym2006，66，： | 1 |
| 17 | Synthesis of unsaturated polyester resins based on rosin acrylic acid adduct for coating application显示文摘 | M Ayman M Ashraf K Reem | 2007 | 67(6):549-5632007，67，6： | 1 |
| 18 | Expression of pigment epithelium-derived factor on experimental choroidal neovascularization显示文摘 | Ayman IY Norman M | 2002 | Invest Ophthalmol Vis Sci2002，43，： | 1 |
| 19 | Natural occurrence of boron-containing compounds in plants, algae and microorganisms显示文摘 | VALERY M D REEM S ABED A A | 2002 | Plant Science2002，163，5： | 1 |
| 20 | Synthesis of unsaturated polyester resin based on rosin acrylic acid adduct for coating applications显示文摘 | Ayman M Atta Ashraf M Elsaeed Reem K Farag | 2007 | Reactive & Functional Polymers2007，67，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员