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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 3 | Lastet advances in understanding preeclampsia 显示文摘 | Redman C W G Sargent I L | 2005 | Science2005，308，5728： | 1 |
| 4 | Reduced adipose tissue oxygenation in human obesity:evidence for rarefaction,macrophage chemotaxis,and inflammation without an angiogenic response显示文摘 | Pasarica M Sereda O R Redman L M | | 0，，03： | 1 |
| 5 | The impact of assessing specimen adequacy and number of needle passes for fine-needle aspiration biopsy of thyroid nodules 显示文摘 | REDMAN R ZALAZNICK H MAZZAFERRI E L | 2006 | Thyroid2006，16，1： | 1 |
| 6 | NK cells and pre-eclampsia显示文摘 | Sargent L Borzychowski M Redman G | 2007 | J Reprod Immunol2007，76，3： | 1 |
| 7 | Acupuncture for ovulation induction in polycystic ovary syndrome:a randomized controlled trial显示文摘 | Johansson J Redman L Veldhuis PP | 2013 | Am J Physiol Endocrinol Metab2013，304，9： | 1 |
| 8 | Taura syndrome in Penaeus vammmei: demonstration of a viral etiology显示文摘 | Hasson K W Lighter D V Poulos B T Poulos B T Redman R M White B L Brock J A Bonmi J R | 1995 | Dis aquat Org1995，23，： | 1 |
| 9 | Role of cell surface lipopolysac- eharides in Escherichia coli K12 adhesion and transport显示文摘 | Walker S L Redman J A Elimelech M | 2004 | Langmuir2004，20，18： | 1 |
| 10 | Field studies of the GPR ground wave method for estimating soil water content during irrigation and drainage显示文摘 | Galagedara L W Parkin G W Redman J D | 2005 | J Hydrol2005，301，： | 1 |
| 11 | Natural organic matter affects arsenic speciation and sorption onto hematite显示文摘 | Redman A D Macalady D L Ahmann D | 2002 | Environmental Science & Technology2002，35，13： | 1 |
| 12 | Placental stress and pre - eclamp- sia: a revised view显示文摘 | REDMAN C W SARGENT I L | 2009 | Placenta2009，30，： | 1 |
| 13 | A Multivariate Analysis of REIT Performance by Financial and Real Estate Portfolio Characteristics显示文摘 | Arnold L Redman | 1995 | Journal of Real Estate Finance and Economics1995，10，： | 1 |
| 14 | Natural organic matter af-fects arsenic speciation and sorption onto hematite显示文摘 | REDMAN A D MACALADY D L AHMANN D | 2002 | Environ Sci Techn-ol2002，36，13： | 1 |
| 15 | Effect of a synthetic progestin on the exercise status of sedentary young women显示文摘 | Redman L M Scroop G C Westlander G | 2005 | J Clin Endocrinol Metab2005，90，7： | 1 |
| 16 | Early reconstitution of immunity and decreased severity of herpes zoster in bone marrow transplant recipients immunized with inactivated varicella vaccine显示文摘 | Redman R L Nader S Zerboni L | | 0，，： | 1 |
| 17 | Determination of the in- fectious nature of the agent of acute hepatopancreaticnecrosissyndrome affecting penaeid shrimp 显示文摘 | Tran L Nunan L Redman RM | 2013 | Diseases of Aquatic Or- ganisms2013，105，： | 1 |
| 18 | Latest advances in understanding preeclampsia 显示文摘 | Redman CW Sargent L | 2005 | Science2005，308，5728： | 1 |
| 19 | Determination of the infectious nature of the agent of acute hepatopancreatic necrosis syndrome affecting penaeid shrimp显示文摘 | Tran L Nunan L Redman R M | 2013 | Diseases of aquatic organisms2013，，105： | 1 |
| 20 | Determination of the infectious nature of the agent of acute hepatopancreatic necrosis syndrome affecting penaeid shrimp显示文摘 | Tran L Nunan L Redman R M | 2013 | Diseases of Aquatic Organisms2013，105，： | 1 |
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