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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Metal Hydride Compaccts for Hydride Isotope Separation显示文摘 | Heung L K Tran R S | 1991 | J Less-Common Met1991，，： | 2 |
| 3 | Neuro-fuzzy TSK network for approximation of static and dynamic functions 显示文摘 | Tran Haoi L Osowski S | 2002 | Control and Cybernetics2002，31，2： | 1 |
| 4 | Differential ex-pression of isoflavone biosynthetic genes in soybean during water deficits显示文摘 | GONZALEZ J G GUTTIKONDA S K TRAN L S P | 2010 | Plant Cell Physiol2010，51，6： | 1 |
| 5 | Physiological and molecular approaches to improve drought re- sistance in soybean显示文摘 | Manavalan L P Guttikonda S K Tran L S | 2009 | Plant Cell Physiol2009，50，7： | 1 |
| 6 | A randomized controlled trial of sequentially bilateral prefrontal cortex repetitive transcranial magnetic stimulation in the treatment of negative symptoms in schizophrenia显示文摘 | Barr M S Farzan F Tran L C | 2012 | Brain Stimul2012，5，3： | 1 |
| 7 | Combustion-derivednanoparticles:a review of tJieir toxicology following inhalationexposure显示文摘 | Donaldson K Tran L Jimenez LA | 2005 | Part Fibre Toxicol2005，2，： | 1 |
| 8 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 9 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 10 | Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel显示文摘 | Ang L Palakodeti V Khalid A Tsimikas S Idrees Z Tran P | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 11 | Physicochemical properties of native and partially gelatinized high-amylose jackfruit (Artocarpus heterophyllus Lain)seed starch显示文摘 | Tran P L Dang H D N Do V H | 2015 | Lebensmittel- Wissenschaft und-Technologie2015，62，2： | 1 |
| 12 | Comparison of fuzzy numbers using a fuzzy distance measure 显示文摘 | Tran L Duckein L | 2002 | Fuzzy Sets Systems2002，35，3： | 1 |
| 13 | Aedes aegypti in Ho Chi Minh city (Viet Nam):susceptibility to dengue 2 virus and genetic differentiation显示文摘 | Tran KT Vazeille FM Mousson L | 1999 | Trans R Soc Trop Med Hyg1999，93，： | 1 |
| 14 | Synthesis and biological evaluations of 3-substituted indolin-2-ones:a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases显示文摘 | Sun L Tran N Tang F | 1998 | J Med Chem1998，41，14： | 1 |
| 15 | Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought responsive Cis-element in the EARLY RESPONSIVE TO DEHYDRATION STRESS promoter显示文摘 | TRAN L NAKASHIMA K SAKUMA Y SIMPSON S D FUJITA Y MARUYAMA K FUJITA M SEKI M SHINOZAKI K YAMAGUCHI-SHINOZAKI K | 2004 | The Plant Cell2004，16，9： | 1 |
| 16 | Reduction of NOx by plasma-facilitated catalysis over In- doped alumina显示文摘 | Tran D N Aardahl C L Rappe KG | 2004 | Appl Catal B: Environ2004，48，2： | 1 |
| 17 | A role for survivin in chemoresistance ofendothelial cells mediated by VEGF显示文摘 | Tran J Master Z Yu J L | 2002 | Proc Natl Acad Sci USA2002，99，7： | 1 |
| 18 | Mullerian inhibiting substance inhibits breast cancer cell growth through an NFkB imediated pathway显示文摘 | Segev D L Ha T U Tran T T | 2000 | J Biol Chem2000，15，28： | 1 |
| 19 | Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues 显示文摘 | Waltregny D De Leval L Glenisson W Ly Tran S North B J Bellahcfine A | 2004 | Am J Pathol2004，165，： | 1 |
| 20 | Prenatal diagnosis of placenta accreta: Sonography or magnetic resonance imaging? 显示文摘 | Dwyer BK Belogolovkin V Tran L | 2008 | J Ultrasound Med2008，，： | 1 |
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