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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Optimal Low-Thrust Transfers to Synchronous Orbit 显示文摘 | Redding D C Breakwell J V | 1984 | Journal of Guidance Control and Dynamics1984，7，2： | 1 |
| 3 | Tandem arrayed ligation of expressed sequence tags (TALEST): a new method for generating global gene expression profiles 显示文摘 | Spinella D G Bernardino A K Redding A C | 1999 | Nucleic Acids Res1999，27，18： | 1 |
| 4 | The development of critical thinking among students in baccalaureate nursing education显示文摘 | REDDING D A | 2001 | Holist Nurs Pract2001，15，4： | 1 |
| 5 | Occurrence and accumulation of pesticides and organic contaminants in river sediment,water and clam tissues from the San Joaquin river and tributaries,California显示文摘 | Wilf red E D Pereira L Joseph | 1996 | Environmental Toxicology and Chemistry1996，15，2： | 1 |
| 6 | Comparison of su|fasalazine and placebo in the treatment of ankylosing spondylitis : a department of Veterans Cooperative Study显示文摘 | Clegg DO Reds D J Weismith MH | 1996 | Arthritis Rheum1996，39，12： | 1 |
| 7 | Professional values held by bacca- laureate and associate degree nursingstudcnts 显示文摘 | Martin P Yarbrough S Alf red D | 2003 | Journal of Nursing Scholarship2003，35，3： | 1 |
| 8 | Sodium hydroxide pretreatment and enzymatic hydrolysis of coastal Bermuda grass显示文摘 | WANG Z KESHWANI D R REDDING A P | 2010 | Bioresour Technol2010，101，10： | 1 |
| 9 | Study of nitrate stress in Desulfovibrio vulgaris Hildenborough using iTRAQ proteomics显示文摘 | Redding A M Mukhopadhyay A Joyner D C | 2006 | Brief Funct Genomic Proteomic2006，5，2： | 1 |
| 10 | Vision-based Target Gee-location using a Fixed-wing Minia-ture Air Vehicle显示文摘 | Blake Barber D Joshua D Redding Timothy W McLain | | 0，，04： | 1 |
| 11 | Histological and biological evolution of human premalignant breast disease显示文摘 | All red D Mohsin S Fuqua S | 2001 | Endoer - Rel Cancer2001，8，： | 1 |
| 12 | Hubble Space Telescope Prescription Retrieval显示文摘 | Redding D Dument P Yu J | 1993 | Applied Optics1993，32，10： | 1 |
| 13 | Finding a benchmark for monitoring hospital cleanliness显示文摘 | Mulvey D Redding P Robertson C | 2011 | J Hosp Infect2011，77，1： | 1 |
| 14 | Vision-based target geo-location using a fixed-wing miniature airvehicle 显示文摘 | BARBER D B REDDING J D MCLAIN T W | 2006 | Journal of Intelligent and Robotic Systems2006，47，4： | 1 |
| 15 | The costs of remoteness:Evidence from German divison and reunification显示文摘 | Redding S Sturm D | 2008 | American Economic Review2008，98，5： | 1 |
| 16 | Genetic winter wheat cultivars as evaluated by pedigree analysis and gliadin polyacrylamide gel eletrophoretic patterns 显示文摘 | COX T S LOOKHART G L relationships among hard red WALKER D E | 1985 | Crop Science1985，25，6： | 1 |
| 17 | The Costs of Remoteness: Evidence from German Division and Reunification 显示文摘 | Redding S J Sturm D A | 2008 | The American Economic Review2008，98，5： | 1 |
| 18 | The costs of remoteness: evidence from german division and reunification 显示文摘 | Redding S D Sturm | 2008 | American Economic Re- view2008，98，5： | 1 |
| 19 | Vision- based target geo-location using a fixed-wing miniature air ve- hicle 显示文摘 | BARBER D B REDDING J D MCLAIN T W | 2006 | Journal of Intelligent and Robotic Systems2006，47，4： | 1 |
| 20 | Two nonlinear control approaches for retrieval of a thrusting tethered subsatellite显示文摘 | Pines D J von Flotow A H Redding D C | 1990 | J Guid Control Dyn1990，13，4： | 1 |
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