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| 1 | Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms显示文摘简明比喻, ‘免疫系统装载了 gun' ,被用来在能在需求上几乎立即被释放与侵略者作斗争的能分泌的小粒由于他们大量有势力支持 inflammatory 和抗菌剂调停人的存储描述桅杆房间(MC ) 的角色。在主人环境定位了边界并且与模式识别受体的一个军火库装备了, MC 被注定是渗透 endothelial 和上皮的表面的病原体的快速的天生的传感器。尽管在抗菌剂和 antiparasitic 防卫的 MC 的重要性长被欣赏了,他们在对病毒的感染发出报警的角色仅仅最近被注意了。 cytomegalovirus ( CMV )上的工作在鼠科的模型的感染在在 CMV 的天生、适应的有免疫力的监视之间的新奇串音轴作为播放器揭示了 MC 在 MC ,它与 MC degranulation 和 chemokine CCL5 的版本被联系的那感染,提高保护的 CD8 T 房间的招募到病毒复制的血管外的地点,明确地到肺 interstitium 和牙槽的上皮。这里,我们由响应主人感染为 MC 激活和作为结果的 degranulation 调查条件阐述了这些研究。令人惊讶地,数据揭示了 MC 激活的二个时间地并且机械学地不同的波浪:取决于 TLR3/TRIF 发信号并且由没包含 TLR3/TRIF 发信号的 MC 的直接感染推迟了激活的几乎立刻的间接激活。产出有选择地从 MC 发源的表示 eGFP 记者病毒的房间类型特定的 Cre 再结合识别了是的 MC 一在 vivo 新,生产鼠科的 CMV 感染的第一点击的目标房间。 | Marc Becker Niels AW Lemmermann Stefan Ebert Pamela Baars Angelique Renzaho Jurgen Podlech Michael Stassen Matthias J Reddehase | 2015 | Cellular & Molecular Immunology2015，12，2： | 1 |
| 2 | Lungs are a major organ site of cytomegalovirus latency and recurrence显示文摘 | Balthesen M Messerle M Reddehase MJ | 1993 | J Virol1993，67，9： | 1 |
| 3 | Mouse models of cytomeg- alovirns latency: overview显示文摘 | Reddehase M J Podlech J Grzimek N K | 2002 | J Clin Virol2002，25，2： | 1 |
| 4 | Mouse models of cytomegalovirus latency:overview显示文摘 | Reddehase MJ Podlech J Grzimek NK | | 0，，2： | 1 |
| 5 | The conditions of primary infection define the load of latent viral genome in organs and the risk of recurrent cytomegalovirus disease 显示文摘 | Reddehase M J Balthesen M Rapp M | 1994 | J Exp Med1994，179，1： | 1 |
| 6 | Identification of a Kd - restricted antigenic peptide encoded by murine cytomegalovirus early gene M84 显示文摘 | Hohappels R Thomas D Reddehase MJ | 2000 | Journal of General Virology2000，81，16： | 1 |
| 7 | Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection显示文摘 | Seckert CK Renzaho A Reddehase MJ | 2008 | Med Microbiol Immunol2008，197，2： | 1 |
| 8 | Mouse models of cytomegalovirus latency: overview.显示文摘 | Reddehase MJ | | 0，，： | 1 |
| 9 | CD8-positive T lymphocytes specific for murine cytomegalovirus immediateearly antigens mediate protective immunity 显示文摘 | Reddehase MJ Mutter W Munch K | 1987 | J Virol1987，61，10： | 1 |
| 10 | TLR3-independent activation of mast cells by cytomegalovirus contributes to control of pulmonary infection显示文摘 | Niels AW Lemmermann Matthias J Reddehase | 2017 | Cellular & Molecular Immunology2017，14，6： | 1 |
| 11 | Phenotypic discrimination between thymic and extrathymic CD4^-CD8^- and CD4^+ CD8^+ porcine T lymphocytes显示文摘 | Saalmuller A Hirt W Reddehase M J | 1989 | Eur J Immunol1989，19，11： | 1 |
| 12 | Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes显示文摘 | Saalmüller A Reddehase MJ Rg Bühring H J | 1987 | Eur J Immunol1987，17，： | 1 |
| 13 | Phenotypic Discrimination between Thymic and Extrathymic CD4^-CD8^--and CD4^^+ CD8^^+ Porcine Tymphocytes显示文摘 | SAALMULLER A HIRT W REDDEHASE M J | 1989 | Eur J Immunol1989，19，： | 1 |
| 14 | Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection显示文摘 | Stefan Ebert Jürgen Podlech Dorothea Gillert-Marien Kerstin M. Gergely Julia K. Büttner Annette Fink Kirsten Freitag Doris Thomas Matthias J. Reddehase Rafaela Holtappels | 2012 | Medical Microbiology and Immunology2012，，4： | 1 |
| 15 | The immunogenicity of human and murine cytomegaloviruses 显示文摘 | REDDEHASE M J | 2000 | Current Opinion in Immunology2000，12，6： | 1 |
| 16 | CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity显示文摘 | I Reddehase M J Mutter W Munch K | 1987 | J Virol1987，61，10： | 1 |
| 17 | Identification of a K(d) -restricted antigenic peptide encoded by murine cytomegalovirus early gene M84 显示文摘 | Holtappels R Thomas D Reddehase MJ | 2000 | J Gen Virol2000，81，12： | 1 |
| 18 | Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes显示文摘 | Saalmuller A Reddehase M J Buhring H J | 1987 | Eur J Immunol1987，17，： | 1 |
| 19 | Exogenous introduction of an immunodominant peptide from the non-structural IE1 protein of human cytomegalovirus into the MHC class I presentation pathway by recombinant dense bodies显示文摘 | Mersseman V Besold K Reddehase M J | 2008 | J Gen Virol2008，89，2： | 1 |
| 20 | Gamma/delta T-lymphocyte subsets in swine 显示文摘 | Reddehase MJ Saalmuller A Hilt W | 1991 | Curr Top Microbiol Immunol1991，173，： | 1 |
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