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| 1 | Prognostic relevance of normocytic anemia in elderly patients affected by cardiovascular disease显示文摘BACKGROUND Anemia associated with cardiovascular diseases(CVD) is a common condition in older persons. Prevalence and prognostic role of anemia were extensively studied in patients with myocardial infarction(MI) or congestive heart failure(CHF) whereas limited data were available on patients with atrial fibrillation(AF). This study was conducted to assess the clinical prevalence and prognostic relevance of anemia in elderly patients affected by AF and other CVDs.METHODS A total of 866 elderly patients(430 men and 436 women, age: 65-98 years, mean age: 85 ± 10 years) were enrolled.Among these patients, 267 patients had acute non-ST-segment elevation MI(NSTEMI), 176 patients had acute CHF, 194 patients had acute AF and 229 patients were aged-matched healthy persons(CTR). All parameters were measured at the hospital admission and cardiovascular mortality was assessed during twenty-four months of follow-up.RESULTS The prevalence of anemia was higher in NSTEMI, CHF and AF patients compared to CTR subjects(50% vs. 15%, P <0.05), with normocytic anemia being the most prevalent type(90%). Adjusted mortality risk was higher in anemic patient versus non-anemic patient in all the groups of patients [NSTEMI: hazard ratio(HR) = 1.81, 95% CI: 1.06-2.13;CHF: HR = 2.49, 95% CI:1.31-4.75;AF: HR = 1.98, 95% CI: 1.01-3.88]. Decreased hemoglobin levels(P = 0.001) and high reticulocyte index(P = 0.023) were associated with higher mortality in CVD patients.CONCLUSIONS The significant associations between CVD and anemia and the prognostic relevance of anemia for elderly patients with CVD were confirmed in this study. The presence of anemia in AF patients is associated with a two-fold increased mortality risk compared with non-anemic AF patients. Low hemoglobin and high reticulocyte count independently predict mortality in elderly patients with CVD. | Liana Spazzafumo Fabiola Olivieri Jacopo Sabbatinelli Roberta Galeazzi Rina Recchioni Fiorella Marcheselli Paola Tamburrini Roberto Antonicelli | 2021 | Journal of Geriatric Cardiology2021，18，8： | 3 |
| 2 | A sodium channel opener inhibits stimulation of human peripheral blood mononuclear cells显示文摘 | FIERI C RECCHIONI R MORONI F | 1992 | Mol Immunol1992，29，4： | 1 |
| 3 | Melatonin: A peroxyl radical scavenger more effective than vitamin E 显示文摘 | Marra M Moroni F Recchioni R Marcheselli F | 1994 | Life Sci1994，55，15： | 1 |
| 4 | Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation显示文摘 | Trubiani O Recchioni R Moroni F Pizzicannella J Caputi S Di Primio R | 2005 | J Pineal Res2005，39，4： | 1 |
| 5 | Analysis of quadrature methods for pricing discrete barrier options显示文摘 | Fusai G Recchioni M C | 2007 | Journal of Economic Dynamics&Control2007，31，3： | 1 |
| 6 | Experimental apoptosis provides clues about the role of mitochondrial changes in neuronal death显示文摘 | Fattoretti P Bertoni F C Recchioni R | 2006 | Ann N Y Acad Sci2006，1090，1： | 1 |
| 7 | Analysis of quadrature methods for pricing discrete barrier options显示文摘 | Fusai G Recchioni M C | 2007 | Journal of Economic Dynamics & Control2007，31，3： | 1 |
| 8 | Diagnostic accuracy of percent free prostate-specific antigen in prostatic pathology and its usefulness in monitoring prostatic cancer patients显示文摘 | Minardi D Galosi A B Recchioni A | 2001 | Urol Int2001，67，4： | 1 |
| 9 | Vitamin E deficiency impairs the modifications of mitoehondrial membrane potential and mass in rat splenocytes stimulated to proliferate 显示文摘 | Pieri C Moroni F Recchioni R | 1993 | Free Radic Biol Med1993，15，6： | 1 |
| 10 | Upper extrem- ity deep vein thrombosis after suspension of progesterone-only oral treatme 显示文摘 | Lapeeorella M ()recchioni A Dell'Orso L | 2007 | Blood Coagul Fibrinolysis2007，18，5： | 1 |
| 11 | MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling 显示文摘 | Olivieri F Lazzarini R Recchioni R | 2013 | Age(Dordr)2013，35，4： | 1 |
| 12 | Analysis of quadrate methods for pricing discrete barrier options 显示文摘 | Fusai G Recchioni M C | 2007 | Journal of Economic Dynamics & Control 20072007，，： | 1 |
| 13 | Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation 显示文摘 | Trubiani O Recchioni R Moroni F Pizzicannella J Caputi S Di Primio R | 2005 | J Pineal Res2005，39，4： | 1 |
| 14 | Diagnostic accuracy of percent free prostate-specific antigen in prostatic pathology and its usefulness in monitoring prostatic cancer patients 显示文摘 | Minardi D Galosi AB Recchioni A | 2001 | Urol Int2001，67，4： | 1 |
| 15 | MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling显示文摘 | Olivieri F Lazzarini R Recchioni R | | 0，，： | 1 |
| 16 | The impairment of mitochondrial membrane potential and mass in proliferating lymphocytes from vitamin E deficient animals is recovered by glutathione显示文摘 | Pieri C Recchioni R Marcheselli F | 1995 | Cell Mol Biol1995，41，6： | 1 |
| 17 | Conven- tional and novel diagnostic biomarkers of acute myocardial in- farctian: a promising role for circulating microRNAs显示文摘 | RECCHIONI R MARCHESELLI F OLIVIERI F | 2013 | Biomark- ers2013，18，7： | 1 |
| 18 | The use of wavelets in the operator expansion method for time-dependent acous- tic obstacle scattering显示文摘 | Recchioni M C Zirilli F | 2004 | SIAM Journal on Scientific Computing2004，25，4： | 1 |
| 19 | Tuberculous spondylitis: a retrospective study on a series of 12 patients operated on in a 25-year period 显示文摘 | Rychlicki F Messori A Recchioni M A | 1998 | J Neurosurg Sci1998，42，： | 1 |
| 20 | Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction显示文摘 | Fabiola Olivieri Roberto Antonicelli Maria Lorenzi Yuri D’Alessandra Raffaella Lazzarini Gabriele Santini Liana Spazzafumo Rosamaria Lisa Lucia La Sala Roberta Galeazzi Rina Recchioni Roberto Testa Giulio Pompilio Maurizio C. Capogrossi Antonio Domenico P | 2012 | International Journal of Cardiology2012，，： | 1 |
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