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| 1 | Prognostic relevance of normocytic anemia in elderly patients affected by cardiovascular disease显示文摘BACKGROUND Anemia associated with cardiovascular diseases(CVD) is a common condition in older persons. Prevalence and prognostic role of anemia were extensively studied in patients with myocardial infarction(MI) or congestive heart failure(CHF) whereas limited data were available on patients with atrial fibrillation(AF). This study was conducted to assess the clinical prevalence and prognostic relevance of anemia in elderly patients affected by AF and other CVDs.METHODS A total of 866 elderly patients(430 men and 436 women, age: 65-98 years, mean age: 85 ± 10 years) were enrolled.Among these patients, 267 patients had acute non-ST-segment elevation MI(NSTEMI), 176 patients had acute CHF, 194 patients had acute AF and 229 patients were aged-matched healthy persons(CTR). All parameters were measured at the hospital admission and cardiovascular mortality was assessed during twenty-four months of follow-up.RESULTS The prevalence of anemia was higher in NSTEMI, CHF and AF patients compared to CTR subjects(50% vs. 15%, P <0.05), with normocytic anemia being the most prevalent type(90%). Adjusted mortality risk was higher in anemic patient versus non-anemic patient in all the groups of patients [NSTEMI: hazard ratio(HR) = 1.81, 95% CI: 1.06-2.13;CHF: HR = 2.49, 95% CI:1.31-4.75;AF: HR = 1.98, 95% CI: 1.01-3.88]. Decreased hemoglobin levels(P = 0.001) and high reticulocyte index(P = 0.023) were associated with higher mortality in CVD patients.CONCLUSIONS The significant associations between CVD and anemia and the prognostic relevance of anemia for elderly patients with CVD were confirmed in this study. The presence of anemia in AF patients is associated with a two-fold increased mortality risk compared with non-anemic AF patients. Low hemoglobin and high reticulocyte count independently predict mortality in elderly patients with CVD. | Liana Spazzafumo Fabiola Olivieri Jacopo Sabbatinelli Roberta Galeazzi Rina Recchioni Fiorella Marcheselli Paola Tamburrini Roberto Antonicelli | 2021 | Journal of Geriatric Cardiology2021，18，8： | 3 |
| 2 | Endoscopic therapy of superficial bladder cancer in high- risk patients:Holmium laser versustransurethral resection显示文摘 | Muraro GB Grifoni R Spazzafumo L | 2005 | Surg Technol Int2005，14，： | 1 |
| 3 | Endoscopic therapy of superficial bladder cancer in high-risk patients: Holmium laser versus thansurethral resection 显示文摘 | Muraro GB Grifoni R Spazzafumo L | 2005 | Surg Technol Int2005，14，： | 1 |
| 4 | Depression, hypertension, and comorbidity: disentangling their specific effect on disability and cognitive impairment in older subjects 显示文摘 | Scuteri A Spazzafumo L Cipriani L | 2011 | Arch Gerontol Geriatr2011，52，： | 1 |
| 5 | Endoscopic therapy of superficial bladder cancer in high-risk patients: Hol- mium laser versus transurethral resection显示文摘 | MURARO GB GRIFONI R SPAZZAFUMO L | 2005 | Surg Technol Int2005，14，： | 1 |
| 6 | Predictors of high level of burden and distress in caregivers of demented patients : results of an Italian multicenter study 显示文摘 | Rinaldi P Spazzafumo L Mastriforti R | 2005 | International Journal of Geriatric Psychiatry2005，20，2： | 1 |
| 7 | Diagnostic potential of plasmatic microRNA signatures in stable and unstable angina 显示文摘 | D'Alessandra Y Carena MC Spazzafumo L | 2013 | PLoS One2013，8，80： | 1 |
| 8 | Social isolation risk factors in older hospitalized individuals显示文摘 | Giuli C Spazzafumo L Sirolla C | 2012 | Arch Gerontol Geriatr2012，55，： | 1 |
| 9 | Depression,hypertension,and comorbidity:disentangling their specific effect on disability and cognitive impairment in older subjects显示文摘 | Scuteri A Spazzafumo L Cipriani L | | 0，，： | 1 |
| 10 | Predictors of high level of burden and distress in earegivers of demented patients : Results of an I- talian multicenter study显示文摘 | Rinaldi P Spazzafumo L Mastriforti R | 2005 | International Journal of Geriatric Psychia- try2005，20，2： | 1 |
| 11 | Adiposity predicts cognitive decline in older persons with diabetes:A 2-year follow-up显示文摘 | Abbatecola AM Lattanzio F Spazzafumo L | 2010 | PLoS One2010，5，10： | 1 |
| 12 | The caregiver burden in- ventory in evaluating the hurden of caregivers of elderly demented pa- tients : Results from a multicenter study 显示文摘 | Marvardi M Mattioli P Spazzafumo L | 2005 | Aging Clinical and Ex- perimental Research2005，17，1： | 1 |
| 13 | Admission levels of circulating miR-499-5p and risk ofdeath in elderly patients after acute non -ST elevationmyocardial infarction 显示文摘 | Olivieri F Antonicelli R Spazzafumo L | | Int J Cardiol0，172，27： | 1 |
| 14 | Permanent ventricular and dual chamber cardiac stimulation: role of pacing mode in relation to chronic atrial fibrillation risk and stroke development显示文摘 | Gabriele Saccomanno Aureliano Fraticelli Marinella Marini Liana Spazzafumo Enrico Paciaroni | 1999 | Archives of Gerontology and Geriatrics1999，，1： | 1 |
| 15 | Depression,hypertension,and comorbidity:disentangling their specific effect on disability and cognitive impairment in older subjects显示文摘 | Scuteri A Spazzafumo L Cipriani L | | 0，，： | 1 |
| 16 | Depression,hypertension,and comorbidity:Disentangling their specific effect on disability and cognitive impairment in older subjects显示文摘 | Scuteri A Spazzafumo L Cipria L | 2011 | Arch Gerontol Geriatr2011，52，3： | 1 |
| 17 | Admission levels ofcirculating miR-499-5p and risk of death in elderly patients afteracute non-ST elevation myocardial infarction 显示文摘 | Olivieri F Antonicelli R Spazzafumo L | 2014 | Int J Cardiol2014，172，2： | 1 |
| 18 | South Patagonia:Wind/hydrogen/coal system with reduced CO2emissions显示文摘 | SPAZZAFUMO G | 2013 | International journal of hydrogen energy2013，38，18： | 1 |
| 19 | Com bined power and hydrogen production from coal,part B comparison between the IGHP and CPH systems显示文摘 | CICCONARDI S PERNA A SPAZZAFUMO G | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 20 | Endoscopic therapy of superficial bladder cancer in high-risk patients :holmium laser versus transurethral resection 显示文摘 | Muraro G B Grifoni R Spazzafumo L | 2005 | Surg Techonl Int2005，14，： | 1 |
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