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| 1 | Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra high performance liquid chromatography (UHPLC)- tandem mass spectrometry ( MS/MS ) 显示文摘 | REBECA L S MIRA P DAMIA B | 2011 | Chemosphere2011，85，8： | 1 |
| 2 | Comparative assessment of a biofilter, a biotrickling filter and a hollow fiber membrane bioreactor for odor treatment in wastewater treatment plants显示文摘 | Raquel Lebrero Ana Celina Gondim Rebeca Pérez Pedro A. García-Encina Raúl Mu?oz | 2013 | Water Research2013，，： | 1 |
| 3 | Occurrence and distribution of pharmaceuticals in surface water,suspended solids and sediments of the Ebro River Basin,Spain显示文摘 | Silva B F D Jelic A Rebeca L S Mozeto A A Petrovic M Barceló D | | 0，，8： | 1 |
| 4 | Occurrence and distribution of pharmaceuticals in surface water, suspended solids and sediments of the Ebro river basin, Spain显示文摘 | Bianca Ferreira da Silva Aleksandra Jelic Rebeca López-Serna Antonio A. Mozeto Mira Petrovic Damià Barceló | 2011 | Chemosphere2011，，8： | 1 |
| 5 | Occurrence anddistribution of pharmaceuticals in surface water,suspended solidsand sediments of the Ebro river basin,Spain显示文摘 | Bianca F S Aleksandra J Rebeca L S | 2011 | Chemosphere2011，85，8： | 1 |
| 6 | Curative Laparoscopic Resection for Pancreatic Neoplasms: A Critical Analysis from a Single Institution显示文摘 | Laureano Fernández-Cruz Rebeca Cosa Laia Blanco Sammy Levi Miguel-Angel López-Boado Salvador Navarro | 2007 | Journal of Gastrointestinal Surgery2007，，12： | 1 |
| 7 | Curative Laparoscopic Resection for Pancreatic Neoplasms: A Critical Analysis from a Single Institution显示文摘 | Laureano Fernández-Cruz Rebeca Cosa Laia Blanco Sammy Levi Miguel-Angel López-Boado Salvador Navarro | 2007 | Journal of Gastrointestinal Surgery2007，，12： | 1 |
| 8 | Translating animal doses of task - specific training to people with chronic stroke in one hour therapy sessions : apreof - of - concept study 显示文摘 | Rebeca L Eliza M Catherine E | 2010 | Neurorehabil Neural Re- pair2010，24，7： | 1 |
| 9 | PORPHOBILINOGEN DEAMINASE deficiency alters vegetative and reproductive development and causes lesions in arabidopsis显示文摘 | Victor Q Raquel S M Rebeca G B Andrea H Maria R P Jose L M | 2013 | PLoS ONE2013，8，53： | 1 |
| 10 | Curative Laparoscopic Resection for Pancreatic Neoplasms: A Critical Analysis from a Single Institution显示文摘 | Laureano Fernández-Cruz Rebeca Cosa Laia Blanco Sammy Levi Miguel-Angel López-Boado Salvador Navarro | 2007 | Journal of Gastrointestinal Surgery2007，，12： | 1 |
| 11 | Machine perfusion and the prevention of ischemic type biliary lesions following liver transplant:What is the evidence?显示文摘The widespread uptake of different machine perfusion(MP)strategies for liver transplant has been driven by an effort to minimize graft injury.Damage to the cholangiocytes during the liver donation,preservation,or early posttransplant period may result in stricturing of the biliary tree and inadequate biliary drainage.This problem continues to trouble clinicians,and may have catastrophic consequences for the graft and patient.Ischemic injury,as a result of compromised hepatic artery flow,is a well-known cause of biliary strictures,sepsis,and graft failure.However,very similar lesions can appear with a patent hepatic artery and these are known as ischemic type biliary lesions(ITBL)that are attributed to microcirculatory dysfunction rather than main hepatic arterial compromise.Both the warm and cold ischemic period duration appear to influence the onset of ITBL.All of the commonly used MP techniques deliver oxygen to the graft cells,and therefore may minimize the cholangiocyte injury and subsequently reduce the incidence of ITBL.As clinical experience and published evidence grows for these modalities,the impact they have on ITBL rates is important to consider.In this review,the evidence for the three commonly used MP strategies(abdominal normothermic regional perfusion[A-NRP],hypothermic oxygenated perfusion[HOPE],and normothermic machine perfusion[NMP])for ITBL prevention has been critically reviewed.Inconsistencies with ITBL definitions used in trials,coupled with variations in techniques of MP,make interpretation challenging.Overall,the evidence suggests that both HOPE and A-NRP prevent ITBL in donated after circulatory death grafts compared to cold storage.The evidence for ITBL prevention in donor after brain death grafts with any MP technique is weak. | Manuel Durán Rafael Calleja Angus Hann George Clarke Ruben Ciria Anisa Nutu Rebeca Sanabria-Mateos María Dolores Ayllón Pedro López-Cillero Hynek Mergental Javier Briceño M Thamara P R Perera | 2023 | World Journal of Gastroenterology2023，29，20： | 0 |
| 12 | A new device for deep cervical artificial insemination in gilts reduces the number of sperm per dose without impairing final reproductive performance显示文摘Background: The aim of this study was to evaluate the reproductive performance of a new artificial insemination(AI) device specifically designed for gilts(Deep cervical AI, Dp-CAI) by means of which the sperm is deposited deeply in the cervix(8 cm more cranial than in traditional cervical insemination-CAI). New AI techniques have arisen in recent decades in the porcine industry, such as post-cervical artificial insemination(PCAI), which involves depositing the sperm in the body of the uterus [through a catheter(outer tube)-cannula(inner tube)] rather than by CAI. Although the PCAI method has been successfully applied in farm conditions to reduce sperm doses without impairing the reproductive performance, this technique has limitations in gilts mainly because of the difficulty involved in introducing the inner cannula through the cranial part of the cervix. For this reason, the Dp-CAI method described herein may be considered as an alternative to CAI and PCAI methods in gilts.Results: Gilts were divided in two experimental groups: 1) Dp-CAI: gilts(n = 1166) inseminated using 1.5 × 109 sperm/45 m L;2) CAI(as a control group): gilts(n = 130) inseminated using 2.5 × 10~9 sperm/85 mL. The Dp-CAI method was successfully applied in 88.90% of the gilts, with no differences detected between gilts with 1 or 2 previous oestrus cycles, although the catheter could be introduced more deeply in 2 oestrus gilts(P < 0.05). As the length of the insemination device that could not be introduced increased(at the moment of insemination), so the success rate of the Dp-CAI device fell, as did the total number of piglets born. When the reproductive output in CAI and Dp-CAI was compared, none of the parameters analysed [pregnancy and farrowing rates(%), and number of piglets born(total and live)] showed significant differences.Conclusions: The use of the Dp-CAI technique provides a new AI method as an alternative to CAI and PCAI for pigs. The device, especially designed for gilts, was used with a high degree of success reducing conventional sperm doses without impairing reproductive parameters. | Pedro J.Llamas-López Rebeca López-úbeda Gustavo López Emily Antinoja Francisco A.García-Vázquez | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 0 |
| 13 | Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn's disease显示文摘BACKGROUND Identifying predictors of therapeutic response is the cornerstone of personalized medicine.AIM To identify predictors of long-term mucosal healing(MH) in patients with Crohn's disease(CD) treated with tumor necrosis factor α(TNF-α) inhibitors.METHODS Prospective single center study. Consecutive patients with clinically active CD requiring treatment with a TNF-α inhibitor were included. A baseline segmental CD Endoscopic Index of Severity(CDEIS) ≥ 10 in at least one segment or the presence of ulcerations were required for inclusion. Clinical, biological and endoscopic data were obtained at baseline, weeks 14 and 46. Endoscopic response(ER) was defined as a decrease ≥ 50% from baseline CDEIS and MH as partial CDEIS ≤ 5 in all segments.RESULTS Of 62 patients were included. At baseline, median CD Activity Index and CDEIS were 201 and 6.7, respectively with a significant reduction after one year of treatment(53 and 3.0 respectively, P < 0.001). At week 14, 56% of patients achieved ER and 34% MH. At week 46, the corresponding percentages were 52%and 44%. Baseline disease characteristics or biomarkers did not predict MH. A decrease from baseline CDEIS at week 14 of at least 80% was the best predictor of MH at week 46(59% sensitivity and 91% specificity; area under the curve =0.778).CONCLUSION Clinical and biomarker data are not useful predictors of response to TNF-αinhibitors in CD, whereas ER to induction therapy, defined as 80% reduction in global CDEIS, is a robust predictor of long-term MH. Achievement of this endoscopic endpoint may be considered as a therapeutic target for anti-TNF-αtherapy. | Ignacio Alfaro Maria Carme Masamunt Nuria Planell Alicia López-García Jesús Castro Marta Gallego Rebeca Barastegui Angel Giner Alejandro Vara Azucena Salas Elena Ricart Julián Panés Ingrid Ordás | 2019 | World Journal of Gastroenterology2019，25，14： | 0 |
| 14 | Ten years of lung cancer in a single center: gender, histology, stage and survival显示文摘Aim:The aim was to describe,in a prospective manner,the clinical,histopathological and epidemiological characteristics of lung cancer patients who attended as outpatients at the Lluís Alcanyís,Xàtiva Medical Oncology Hospital,València,Spain from January 2004 to July 2014.We also analyzed survival and compared our data with that reported in the literature.Methods:Clinical and demographic characteristics were analyzed for the entire series and trends were compared by year of diagnosis.Changes in epidemiology were examined and compared.Results:There were 701 patients(91.4%were men,mean age 67.6).Main histology was squamous cell carcinoma(41.5%).Squamous cell carcinoma prevailed in men(45.5%)and adenocarcinoma(ADC)in women(60.3%).The percentage of men with lung cancer and of patients with squamous cell carcinoma was higher than in the reported worldwide data and remained throughout the 10 years period.Mean survival was low,with<10%survivors at 5 years.Stage of disease remained the main prognostic factor for survival.Conclusion:Squamous cell carcinoma continues to be the most frequent histological type in our area.Male and smoking is associated with lung carcinoma while ADC more often occurs in females.Over the time,our epidemiological and histological patterns have not changed,possibly in relation to maintenance of smoking habits. | Regina Gironés Pedro López Rebeca Chulvi Mamen Cañabate Torregrosa M.Dolores | 2015 | Journal of Cancer Metastasis and Treatment2015，1，1： | 0 |
| 15 | Embryo and Endosperm Phytochemicals from Polyembryonic Maize Kernels and Their Relationship with Seed Germination显示文摘Because of the growing worldwide demand for maize grain,new alternatives have been sought for breeding of this cereal,e.g.,development of polyembryonic varieties,which agronomic performance could positively impact the grain yield per unit area,and nutritional quality.The objectives of this study were to(1)determine the phytochemicals present in the embryo and endosperm of grain from maize families with high,low,and null polyembryony frequency,which were planted at different locations,and(2)state the relationship between these compounds and seed germination.The extracted phytochemicals from corn were identified by HPLC-MS.The results showed that the genotype with the highest presence of phytochemicals was the brachytic population with high polyembryony called“BAP”,which also required less water during the germination process.The number of phytochemicals in both embryo and endosperm tissues was not related to the sowing location where they came from or the type of polyembryony.The number of different phytochemicals depended on the grain tissue from where they were extracted.The chemical compounds found in the different maize tissues were related to the development of the plant,either in roots or nibs because these are mainly associated with the lignin synthesis. | J.David García-Ortíz Rebeca González-Centeno María Alejandra Torres-Tapia J.A.Ascacio-Valdés JoséEspinoza-Velázquez Raúl Rodríguez-Herrera | 2022 | Phyton-International Journal of Experimental Botany2022，91，5： | 0 |
| 16 | Do elderly NSCLC stage IV patients benefit from chemotherapy as well as younger?An analysis from clinical practice date显示文摘Aim:The aim of this study was to evaluate the efficacy of treatment related to age in metastatic non-small cell lung cancer(NSCLC).We compared young and elders(>70)in the setting of a regional Spanish hospital.We hypothesized that elder benefit as much as younger patients from chemotherapy in stage IV NSCLC.The study was limited to performance status 0-2.Methods:Clinical and demographic characteristics were reviewed form medical records.Type of treatment was collected and compared,as well as benefit from treatment,in terms of overall survival.Results:322 patients(162 young,160 aged)Elderly patients received less active treatment(63%vs.86%,P=0.001).E lderly r eceived l ess chemotherapy,less cisplatin-doublets,more carboplatin-combinations and monotherapy(P=0.035).T he b enefits o f t reatment w ere s imilar,r egardless o f a ge.S moking s tatus demonstrated a prognosis impact for elder patients treated with chemotherapy.Those who remained active smokers had a lower overall survival in the aged group.In a multivariate analysis,the Eastern Cooperative Oncology Group,active treatment and non-smoking history were favorable prognostic factors for elder patients.Smoking had not impact on young patients.Conclusion:E lderly p atients w ere u ndertreated i n c linical p ractice.Treatment showed similar overall survival despite of age.The impact of smoking seems to be more significant in the elderly population. | Regina Gironés Pedro López Rebeca Chulvi Mamen Cañabate | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
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