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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Cubic to orthorhmbic difusionless phase change-experimentaland theoretical studies of aucd显示文摘 | Lieberman D S Wechsler M S Read T A | 1955 | J Applied Physics1955，26，： | 2 |
| 3 | Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells显示文摘 | Read M A Cordle S R Veach R A | 1993 | Proc Natl Acad Sci U S A1993，90，21： | 2 |
| 4 | A prospective study of the effect of haemorrhoideetomy on sphincter function and faecal continence显示文摘 | Read N W Haynes W G | 1982 | Br J Surg1982，69，7： | 1 |
| 5 | Light-directed spatially addressable parallel chemical synthesis显示文摘 | Read J L Pirrung M C | 1991 | Science1991，251，： | 1 |
| 6 | Design of a gridded gun and PPM-focusing structure for a high-power sheet electron beam显示文摘 | Read M E Jabotinski V Miram G | 2005 | IEEE Trans on Plasma Sci2005，33，2： | 1 |
| 7 | The observation of the non-cova-lent interactions in solution by electrospray ionization massspectrometry: promise, pitfalls and prognosis显示文摘 | Read S M Currier G Bacic A | 1996 | Carbohydr Res1996，281，： | 1 |
| 8 | Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA:differential circulation in mice and rats and the implication for human gene therapy显示文摘 | Ward C M Read M L Seymour L W | 2001 | Blood2001，97，： | 1 |
| 9 | The promoter of a basic PR1-like gene,AtPRB1,from Arabidopsis establishes an organ-specific expression pattern and responsiveness to ethylene and methyl jasmonate显示文摘 | SANTAMARIA M Thomson C J Read N D | 2001 | Plant Molecular Biology2001，47，： | 1 |
| 10 | Fungal specificity bottlenecks durin- gorchid germination and development 显示文摘 | BIDARTONDO M I READ D J | | Molecular Ecology0，17，16： | 1 |
| 11 | Slow recovery of soil biodiversity in sandy loam soils of Georgia after 25 years of no-tillage management agrieuhure显示文摘 | Adl S M Coleman D C Read F | 2006 | Ecosystems and Environment2006，114，： | 1 |
| 12 | An Investigation of the Structure Near the L2, 3 Edges of Argon, the M4, 5 Edges of Krypton and the N4, 5 Edges of Xenon, Using Electron Impact with High Resolution显示文摘 | Tronc M Read F H | 1977 | J Phys1977，10，： | 1 |
| 13 | A comparison of the analgesic effects of butorphanol with those of meloxicam after elective ovariohysterectomy in dogs 显示文摘 | Caulkett N Read M Fowler D | 2003 | Can Vet J2003，44，7： | 1 |
| 14 | A redeseription of Cryptosporidium galli Pavlasek, 1999 (Apicompl- exa: Cryptosporidiidae) from birds 显示文摘 | Ryan U M Xiao L Read C | 2003 | J Parasitol2003，89，： | 1 |
| 15 | Prediction of the mechanical properties of a crosslinking polymer from a combination of the measured kinetics and a model for network growth 显示文摘 | CLAYBOURN M READING M | 1992 | Journal of Applied Polymer Science1992，44，4： | 1 |
| 16 | Cyclicramp-to-basin car-bonate deposits, Lower Mississippian, Wyoming andMontana : A combined field and computer modelingstudy 显示文摘 | ELRICK M READ J F | 1991 | Journal of Sedimentary Petrology1991，，61： | 1 |
| 17 | Using the theory of planned behaviour to investigate the determinants of recycling behaviour:a case study from Brixworth,UK显示文摘 | Tonglet M Phillips P S Read A D | | 0，，41： | 1 |
| 18 | Prevalence and signifi cance of coagulation abnormalities in community acquired pneu monia显示文摘 | Milbrandt EB Reade MC Lee M | 2009 | Mol Med2009，15，1112： | 1 |
| 19 | Analysis of β-lyase metabolites of sulfur mustard in urine by electrospray liquid chromatography-tandem mass spectrometry显示文摘 | READ R W BLACK R M | 2004 | Anal Toxicol2004，28，5： | 1 |
| 20 | A model of disease and vaecination for infections with acute and chronic phasea 显示文摘 | Reade B Bowers R Begon M | 1998 | Theoretical Biology1998，190，： | 1 |
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