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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Light-directed spatially addressable parallel chemical synthesis显示文摘 | Read J L Pirrung M C | 1991 | Science1991，251，： | 1 |
| 3 | Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA:differential circulation in mice and rats and the implication for human gene therapy显示文摘 | Ward C M Read M L Seymour L W | 2001 | Blood2001，97，： | 1 |
| 4 | A redeseription of Cryptosporidium galli Pavlasek, 1999 (Apicompl- exa: Cryptosporidiidae) from birds 显示文摘 | Ryan U M Xiao L Read C | 2003 | J Parasitol2003，89，： | 1 |
| 5 | Chronic dipeptidyl peptidase-4 inhibition with sitagliptin is associated with sustained protection against ischemic left ventricular dysfunction in a pilot study of patients with type 2 diabetes mellitus and coronary artery disease显示文摘 | McCormick L M Kydd A C Read P A | 2014 | Circ Cardiovasc Imaging2014，7，2： | 1 |
| 6 | Narrow-waveband reflectance rations for remote estimation of nitrogen status in cotton 显示文摘 | Read J J Tarpley L Mckinion J M | 2002 | Journal of Environmental Quality2002，31，： | 1 |
| 7 | Light-directed,spatially addressable parallel chemical synthesis显示文摘 | Fodor S P Read J L Pirrung M C | 1991 | Science1991，251，4995： | 1 |
| 8 | Comparative genomesequencing for discovery of novel polymorphisms in Bacillus anthracis 显示文摘 | Read TD Salzberg SL Pop M Shumway M Umayam L Jiang L Holtzapple E Busch JD Smith KL Schupp JM Solomon D Keim P Fraser CM | 2002 | Science2002，296，5575： | 1 |
| 9 | Rapid colorimetric assay for cell viability of cytotoxic and growth inhibitory lymphokines显示文摘 | Green L M Reade J L Ware C F | 1984 | Journal of Immunological Methods1984，70，2： | 1 |
| 10 | Design of Over- moded Interaction Circuit for 1 kW 95 GHz TWT显示文摘 | Kory C L Read M E Ives R L | 2009 | IEEE Trans Electron Devices2009，56，5： | 1 |
| 11 | Light-directed,spatially addressable parallel chemical synthesis显示文摘 | Fodor S P Read J L Pirrung M C | 1991 | Science1991，251，4995： | 1 |
| 12 | Approaches for link- ing whole - body fish tissue residues of mercury or DDT to biological effects thresholds 显示文摘 | Beekvar N Dillon T M Read L B | 2005 | Environmental Toxicology and Chemistry2005，24，8： | 1 |
| 13 | The risk of childhood cancer after neonatal exposure to vitamin K 显示文摘 | KLEBANOFF M A READ J S MILLS J L | 1993 | N Engl J Med1993，329，13： | 1 |
| 14 | LighT-directed,spatially addressable paralled chemical synthesis显示文摘 | FORDOR S P READ J L PIRRUNG M C | | 0，，： | 1 |
| 15 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 16 | Optimisation of siRNA-mediated RhoA silencing in neuronal cultures 显示文摘 | Suggate E L Ahmed Z Read M L | 2009 | Mol Cell Neurosci2009，40，4： | 1 |
| 17 | Light-directed spatially addressable parallel chemical synthesis显示文摘 | Fodor S P A Read J L Pirning M C | 1991 | Science1991，251，15： | 1 |
| 18 | Light-directed,spatially addressable parallel chemical synthesis显示文摘 | Fodor S P Read J L Pirrung M C | 1991 | Science1991，251，4995： | 1 |
| 19 | Loss of asingle N-linked glycan from the hemagglutinin of influ-enza virus is associated with resistance to collectins andincreased virulence in mice 显示文摘 | Reading P C Pickett D L Tate M D | 2009 | Respir Res2009，10，： | 1 |
| 20 | Quantitation andmorphotyping of Candida albicans from healthy mouths and from mouths affected by erythematous candidosis 显示文摘 | BORROMEO G L MCCULLOUGH M J READE P C | 1992 | J Med Vet Mycol1992，30，6： | 1 |
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